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Zinc in PDB 2nz0: Crystal Structure of Potassium Channel KV4.3 in Complex with Its Regulatory Subunit KCHIP1 (Casp Target)

Protein crystallography data

The structure of Crystal Structure of Potassium Channel KV4.3 in Complex with Its Regulatory Subunit KCHIP1 (Casp Target), PDB code: 2nz0 was solved by H.Wang, Y.Yan, Y.Shen, L.Chen, K.Wang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.00 / 3.20
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 112.186, 112.213, 141.051, 90.00, 90.00, 90.00
R / Rfree (%) 26.1 / 31

Other elements in 2nz0:

The structure of Crystal Structure of Potassium Channel KV4.3 in Complex with Its Regulatory Subunit KCHIP1 (Casp Target) also contains other interesting chemical elements:

Calcium (Ca) 4 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Potassium Channel KV4.3 in Complex with Its Regulatory Subunit KCHIP1 (Casp Target) (pdb code 2nz0). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Potassium Channel KV4.3 in Complex with Its Regulatory Subunit KCHIP1 (Casp Target), PDB code: 2nz0:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 2nz0

Go back to Zinc Binding Sites List in 2nz0
Zinc binding site 1 out of 2 in the Crystal Structure of Potassium Channel KV4.3 in Complex with Its Regulatory Subunit KCHIP1 (Casp Target)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Potassium Channel KV4.3 in Complex with Its Regulatory Subunit KCHIP1 (Casp Target) within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn301

b:96.7
occ:1.00
ND1 B:HIS104 2.2 0.5 1.0
SG B:CYS131 2.2 0.6 1.0
SG D:CYS110 2.5 0.5 1.0
SG B:CYS132 2.7 0.3 1.0
CE1 B:HIS104 3.1 0.2 1.0
CB D:CYS110 3.1 0.3 1.0
CG B:HIS104 3.3 0.8 1.0
CB B:CYS132 3.3 1.0 1.0
CB B:CYS131 3.5 0.2 1.0
N B:CYS132 3.7 0.1 1.0
CB B:HIS104 3.7 0.6 1.0
C B:CYS131 3.9 0.3 1.0
CA B:HIS104 4.0 0.7 1.0
CA B:CYS132 4.1 0.0 1.0
NE2 B:HIS104 4.2 0.9 1.0
CA B:CYS131 4.3 0.3 1.0
O B:CYS131 4.3 0.5 1.0
CD2 B:HIS104 4.3 0.4 1.0
CA D:CYS110 4.6 0.5 1.0
N B:TYR105 4.7 1.0 1.0
O B:LEU103 4.8 0.8 1.0
CB D:ALA113 4.9 0.3 1.0
C B:HIS104 4.9 0.8 1.0
N D:ALA113 4.9 0.1 1.0
N B:HIS104 5.0 0.8 1.0

Zinc binding site 2 out of 2 in 2nz0

Go back to Zinc Binding Sites List in 2nz0
Zinc binding site 2 out of 2 in the Crystal Structure of Potassium Channel KV4.3 in Complex with Its Regulatory Subunit KCHIP1 (Casp Target)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Potassium Channel KV4.3 in Complex with Its Regulatory Subunit KCHIP1 (Casp Target) within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Zn301

b:95.1
occ:1.00
SG D:CYS131 2.3 0.4 1.0
ND1 D:HIS104 2.4 0.7 1.0
SG D:CYS132 2.8 0.7 1.0
CE1 D:HIS104 3.2 0.4 1.0
CB D:CYS132 3.3 0.2 1.0
CG D:HIS104 3.5 0.9 1.0
CB D:CYS131 3.5 0.4 1.0
N D:CYS132 3.9 0.9 1.0
C D:CYS131 3.9 0.7 1.0
CB D:HIS104 3.9 0.2 1.0
O D:CYS131 4.1 0.7 1.0
CA D:HIS104 4.2 0.1 1.0
CA D:CYS132 4.2 0.3 1.0
CA D:CYS131 4.3 0.4 1.0
NE2 D:HIS104 4.4 0.1 1.0
CD2 D:HIS104 4.5 0.5 1.0
N D:TYR105 4.7 0.3 1.0
C D:HIS104 5.0 0.1 1.0

Reference:

H.Wang, Y.Yan, Q.Liu, Y.Huang, Y.Shen, L.Chen, Y.Chen, Q.Yang, Q.Hao, K.Wang, J.Chai. Structural Basis For Modulation of KV4 K(+) Channels By Auxiliary Kchip Subunits. Nat.Neurosci. V. 10 32 2007.
ISSN: ISSN 1097-6256
PubMed: 17187064
DOI: 10.1038/NN1822
Page generated: Wed Dec 16 03:44:57 2020

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