Zinc in PDB 2mzh: uc(Nmr) Solution Structure of the Pro Form of Human Matrilysin (Prommp-7) in Complex with Zwitterionic Membrane

All present enzymatic activity of uc(Nmr) Solution Structure of the Pro Form of Human Matrilysin (Prommp-7) in Complex with Zwitterionic Membrane:
3.4.24.23;

The structure of uc(Nmr) Solution Structure of the Pro Form of Human Matrilysin (Prommp-7) in Complex with Zwitterionic Membrane also contains other interesting chemical elements:

Calcium

(Ca)

40 atoms

The binding sites of Zinc atom in the uc(Nmr) Solution Structure of the Pro Form of Human Matrilysin (Prommp-7) in Complex with Zwitterionic Membrane (pdb code 2mzh). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the uc(Nmr) Solution Structure of the Pro Form of Human Matrilysin (Prommp-7) in Complex with Zwitterionic Membrane, PDB code: 2mzh:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the uc(Nmr) Solution Structure of the Pro Form of Human Matrilysin (Prommp-7) in Complex with Zwitterionic Membrane


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of uc(Nmr) Solution Structure of the Pro Form of Human Matrilysin (Prommp-7) in Complex with Zwitterionic Membrane within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn303 b:0.0 occ:1.00 OD1 A:ASP145 2.0 0.0 1.0 OD2 A:ASP145 2.1 0.0 1.0 NE2 A:HIS158 2.3 0.0 1.0 ND1 A:HIS171 2.4 0.0 1.0 CG A:ASP145 2.4 0.0 1.0 NE2 A:HIS143 2.5 0.0 1.0 HE1 A:HIS171 3.1 0.0 1.0 CE1 A:HIS158 3.1 0.0 1.0 CE1 A:HIS171 3.1 0.0 1.0 HE1 A:HIS158 3.3 0.0 1.0 CD2 A:HIS158 3.4 0.0 1.0 CE1 A:HIS143 3.4 0.0 1.0 HE1 A:HIS143 3.5 0.0 1.0 CG A:HIS171 3.5 0.0 1.0 CD2 A:HIS143 3.5 0.0 1.0 HD2 A:HIS158 3.6 0.0 1.0 HB2 A:HIS171 3.7 0.0 1.0 HD2 A:HIS143 3.8 0.0 1.0 CB A:ASP145 3.9 0.0 1.0 O A:GLY144 4.0 0.0 1.0 CB A:HIS171 4.1 0.0 1.0 HB3 A:HIS171 4.2 0.0 1.0 HB3 A:ASP145 4.3 0.0 1.0 ND1 A:HIS158 4.3 0.0 1.0 NE2 A:HIS171 4.4 0.0 1.0 HB2 A:ASP145 4.4 0.0 1.0 HE2 A:PHE160 4.5 0.0 1.0 CG A:HIS158 4.5 0.0 1.0 CD2 A:HIS171 4.5 0.0 1.0 ND1 A:HIS143 4.7 0.0 1.0 C A:GLY144 4.7 0.0 1.0 CG A:HIS143 4.7 0.0 1.0 CA A:ASP145 4.9 0.0 1.0 HA A:ASP145 5.0 0.0 1.0 N A:ASP145 5.0 0.0 1.0

Zinc binding site 2 out of 2 in the uc(Nmr) Solution Structure of the Pro Form of Human Matrilysin (Prommp-7) in Complex with Zwitterionic Membrane


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of uc(Nmr) Solution Structure of the Pro Form of Human Matrilysin (Prommp-7) in Complex with Zwitterionic Membrane within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn304 b:0.0 occ:1.00 OD2 A:ASP71 1.9 0.0 1.0 OD1 A:ASP71 2.1 0.0 1.0 NE2 A:HIS198 2.4 0.0 1.0 NE2 A:HIS204 2.4 0.0 1.0 NE2 A:HIS194 2.4 0.0 1.0 CG A:ASP71 2.5 0.0 1.0 CE1 A:HIS194 3.1 0.0 1.0 CD2 A:HIS204 3.2 0.0 1.0 HE1 A:HIS194 3.3 0.0 1.0 HD2 A:HIS204 3.3 0.0 1.0 CD2 A:HIS198 3.3 0.0 1.0 CE1 A:HIS198 3.4 0.0 1.0 HD2 A:HIS198 3.4 0.0 1.0 CE1 A:HIS204 3.4 0.0 1.0 HE1 A:HIS198 3.5 0.0 1.0 CD2 A:HIS194 3.6 0.0 1.0 HE1 A:HIS204 3.7 0.0 1.0 HD2 A:HIS194 3.9 0.0 1.0 CB A:ASP71 3.9 0.0 1.0 HB2 A:ASP71 4.0 0.0 1.0 HB3 A:ASP71 4.3 0.0 1.0 ND1 A:HIS194 4.3 0.0 1.0 CG A:HIS204 4.4 0.0 1.0 ND1 A:HIS204 4.5 0.0 1.0 ND1 A:HIS198 4.5 0.0 1.0 CG A:HIS198 4.5 0.0 1.0 CG A:HIS194 4.6 0.0 1.0 SG A:CYS67 4.6 0.0 1.0 HA A:ASP71 4.9 0.0 1.0 HB3 A:MET212 5.0 0.0 1.0

S.H.Prior, Y.G.Fulcher, R.K.Koppisetti, A.Jurkevich, S.R.Van Doren. Charge-Triggered Membrane Insertion of Matrix Metalloproteinase-7, Supporter of Innate Immunity and Tumors. Structure V. 23 2099 2015.
ISSN: ISSN 0969-2126
PubMed: 26439767
DOI: 10.1016/J.STR.2015.08.013