Zinc in PDB 2mlr: Membrane Bilayer Complex with Matrix Metalloproteinase-12 at Its Alpha-Face

All present enzymatic activity of Membrane Bilayer Complex with Matrix Metalloproteinase-12 at Its Alpha-Face:
3.4.24.65;

The structure of Membrane Bilayer Complex with Matrix Metalloproteinase-12 at Its Alpha-Face also contains other interesting chemical elements:

Calcium

(Ca)

42 atoms

The binding sites of Zinc atom in the Membrane Bilayer Complex with Matrix Metalloproteinase-12 at Its Alpha-Face (pdb code 2mlr). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Membrane Bilayer Complex with Matrix Metalloproteinase-12 at Its Alpha-Face, PDB code: 2mlr:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Membrane Bilayer Complex with Matrix Metalloproteinase-12 at Its Alpha-Face


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Membrane Bilayer Complex with Matrix Metalloproteinase-12 at Its Alpha-Face within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn301 b:0.0 occ:1.00 O A:PHE237 2.0 0.0 1.0 O A:VAL235 2.0 0.0 1.0 ND1 A:HIS218 2.2 0.0 1.0 CE1 A:HIS218 3.1 0.0 1.0 HE1 A:HIS218 3.2 0.0 1.0 HB2 A:HIS218 3.2 0.0 1.0 C A:PHE237 3.2 0.0 1.0 C A:VAL235 3.2 0.0 1.0 CG A:HIS218 3.4 0.0 1.0 H A:PHE237 3.7 0.0 1.0 N A:PHE237 3.8 0.0 1.0 CB A:HIS218 3.8 0.0 1.0 HA A:PRO238 3.8 0.0 1.0 HB3 A:HIS218 3.9 0.0 1.0 HA A:MET236 4.0 0.0 1.0 C A:MET236 4.0 0.0 1.0 CA A:PHE237 4.1 0.0 1.0 N A:MET236 4.1 0.0 1.0 HA A:VAL235 4.1 0.0 1.0 N A:PRO238 4.1 0.0 1.0 HB3 A:PHE237 4.1 0.0 1.0 CA A:MET236 4.2 0.0 1.0 CA A:PRO238 4.2 0.0 1.0 O A:THR239 4.2 0.0 1.0 NE2 A:HIS218 4.2 0.0 1.0 CA A:VAL235 4.3 0.0 1.0 C A:PRO238 4.3 0.0 1.0 HD12 A:LEU214 4.3 0.0 1.0 O A:PRO238 4.4 0.0 1.0 CD2 A:HIS218 4.5 0.0 1.0 HG13 A:VAL235 4.5 0.0 1.0 O A:MET236 4.6 0.0 1.0 HA A:THR215 4.6 0.0 1.0 CB A:PHE237 4.7 0.0 1.0 HG12 A:VAL235 4.7 0.0 1.0 O A:ALA234 4.8 0.0 1.0 O A:LEU214 4.9 0.0 1.0 N A:THR239 4.9 0.0 1.0 HA A:PHE237 5.0 0.0 1.0

Zinc binding site 2 out of 2 in the Membrane Bilayer Complex with Matrix Metalloproteinase-12 at Its Alpha-Face


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Membrane Bilayer Complex with Matrix Metalloproteinase-12 at Its Alpha-Face within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn302 b:0.0 occ:1.00 OD1 A:ASP170 2.0 0.0 1.0 OD2 A:ASP170 2.1 0.0 1.0 CG A:ASP170 2.4 0.0 1.0 O A:HIS183 3.6 0.0 1.0 CB A:ASP170 4.0 0.0 1.0 ND1 A:HIS183 4.2 0.0 1.0 HB2 A:ASP170 4.3 0.0 1.0 CG A:HIS196 4.4 0.0 1.0 HB3 A:HIS196 4.4 0.0 1.0 HB2 A:HIS196 4.4 0.0 1.0 HB3 A:ASP170 4.4 0.0 1.0 ND1 A:HIS196 4.5 0.0 1.0 CD2 A:HIS196 4.6 0.0 1.0 CB A:HIS196 4.7 0.0 1.0 NE2 A:HIS196 4.7 0.0 1.0 HA A:ASP170 4.7 0.0 1.0 HE1 A:HIS183 4.8 0.0 1.0 CA A:ASP170 4.8 0.0 1.0 CE1 A:HIS196 4.8 0.0 1.0 C A:HIS183 4.8 0.0 1.0 O A:ASP170 4.9 0.0 1.0 HA A:ALA184 4.9 0.0 1.0 HB3 A:HIS183 5.0 0.0 1.0 CE1 A:HIS183 5.0 0.0 1.0

R.K.Koppisetti, Y.G.Fulcher, A.Jurkevich, S.H.Prior, J.Xu, M.Lenoir, M.Overduin, S.R.Van Doren. Ambidextrous Binding of Cell and Membrane Bilayers By Soluble Matrix Metalloproteinase-12. Nat Commun V. 5 5552 2014.
ISSN: ESSN 2041-1723
PubMed: 25412686
DOI: 10.1038/NCOMMS6552