Zinc in PDB 2kkf: Solution Structure of Mll Cxxc Domain in Complex with Palindromic Cpg Dna

All present enzymatic activity of Solution Structure of Mll Cxxc Domain in Complex with Palindromic Cpg Dna:
2.1.1.43;

The binding sites of Zinc atom in the Solution Structure of Mll Cxxc Domain in Complex with Palindromic Cpg Dna (pdb code 2kkf). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Solution Structure of Mll Cxxc Domain in Complex with Palindromic Cpg Dna, PDB code: 2kkf:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Solution Structure of Mll Cxxc Domain in Complex with Palindromic Cpg Dna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Solution Structure of Mll Cxxc Domain in Complex with Palindromic Cpg Dna within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn2001 b:17.8 occ:1.00 SG A:CYS1155 2.3 53.4 1.0 SG A:CYS1161 2.3 42.0 1.0 SG A:CYS1194 2.3 0.4 1.0 SG A:CYS1158 2.3 41.5 1.0 H A:CYS1155 2.5 37.2 1.0 H A:GLY1156 2.7 37.2 1.0 HB2 A:CYS1194 3.0 37.2 1.0 HA A:CYS1194 3.1 42.4 1.0 HB2 A:CYS1161 3.1 37.2 1.0 CB A:CYS1194 3.1 74.3 1.0 N A:CYS1155 3.2 23.1 1.0 HB3 A:CYS1158 3.3 37.2 1.0 H A:CYS1158 3.3 37.2 1.0 CB A:CYS1161 3.4 63.3 1.0 CB A:CYS1158 3.4 53.4 1.0 H A:ASN1196 3.5 37.2 1.0 CB A:CYS1155 3.6 33.2 1.0 HB3 A:ARG1154 3.6 37.2 1.0 H A:GLN1195 3.6 37.2 1.0 CA A:CYS1194 3.6 10.4 1.0 N A:GLY1156 3.6 23.4 1.0 HA A:ARG1154 3.8 51.1 1.0 CA A:CYS1155 3.8 1.1 1.0 H A:CYS1161 3.9 37.2 1.0 HB3 A:CYS1155 3.9 37.2 1.0 H A:GLN1157 4.0 37.2 1.0 N A:CYS1158 4.1 21.3 1.0 HB3 A:CYS1161 4.1 37.2 1.0 HB3 A:CYS1194 4.1 37.2 1.0 C A:ARG1154 4.1 30.3 1.0 N A:GLN1195 4.2 50.3 1.0 HB2 A:CYS1158 4.2 37.2 1.0 C A:CYS1155 4.3 10.2 1.0 CA A:ARG1154 4.3 62.1 1.0 HB2 A:ASN1196 4.3 37.2 1.0 CA A:CYS1158 4.3 11.3 1.0 C A:CYS1194 4.3 55.2 1.0 N A:CYS1161 4.3 41.1 1.0 CB A:ARG1154 4.4 45.4 1.0 CA A:CYS1161 4.4 54.4 1.0 HB2 A:CYS1155 4.4 37.2 1.0 N A:ASN1196 4.5 31.3 1.0 HD22 A:LEU1197 4.5 37.2 1.0 HA A:CYS1161 4.6 20.6 1.0 HB2 A:ARG1154 4.6 37.2 1.0 N A:GLN1157 4.7 34.1 1.0 CA A:GLY1156 4.7 72.4 1.0 O A:ASN1196 4.7 45.4 1.0 HA2 A:GLY1156 4.7 37.2 1.0 O A:CYS1158 4.8 10.2 1.0 C A:ASN1196 4.8 64.1 1.0 HA A:CYS1155 4.8 61.1 1.0 HA A:LEU1197 4.8 45.4 1.0 N A:CYS1194 4.9 72.2 1.0 C A:CYS1158 4.9 1.2 1.0 HD21 A:ASN1196 4.9 37.2 1.0

Zinc binding site 2 out of 2 in the Solution Structure of Mll Cxxc Domain in Complex with Palindromic Cpg Dna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Solution Structure of Mll Cxxc Domain in Complex with Palindromic Cpg Dna within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn2002 b:17.8 occ:1.00 SG A:CYS1167 2.2 63.1 1.0 SG A:CYS1189 2.3 22.2 1.0 SG A:CYS1173 2.3 43.2 1.0 SG A:CYS1170 2.3 33.3 1.0 H A:CYS1167 2.8 37.2 1.0 H A:GLY1168 3.0 37.2 1.0 H A:LYS1190 3.1 37.2 1.0 HB3 A:CYS1170 3.2 37.2 1.0 H A:CYS1170 3.2 37.2 1.0 HB2 A:CYS1173 3.2 37.2 1.0 HA A:CYS1189 3.2 15.2 1.0 CB A:CYS1189 3.3 1.2 1.0 CB A:CYS1170 3.4 20.0 1.0 HB2 A:CYS1189 3.4 37.2 1.0 CB A:CYS1173 3.4 10.1 1.0 N A:CYS1167 3.5 33.4 1.0 CB A:CYS1167 3.6 20.2 1.0 H A:MET1191 3.6 37.2 1.0 H A:CYS1173 3.7 37.2 1.0 CA A:CYS1189 3.7 5.2 1.0 N A:GLY1168 3.8 61.4 1.0 N A:LYS1190 3.8 63.3 1.0 HB3 A:CYS1167 3.9 37.2 1.0 HB3 A:ASP1166 3.9 37.2 1.0 H A:VAL1169 4.0 37.2 1.0 CA A:CYS1167 4.0 12.5 1.0 HA A:ASP1166 4.0 42.0 1.0 HB2 A:LYS1190 4.0 37.2 1.0 N A:CYS1170 4.0 31.5 1.0 HB2 A:MET1191 4.1 37.2 1.0 HB3 A:CYS1173 4.2 37.2 1.0 C A:CYS1189 4.2 3.2 1.0 HB2 A:CYS1170 4.2 37.2 1.0 CA A:CYS1170 4.2 20.3 1.0 HB3 A:CYS1189 4.3 37.2 1.0 N A:CYS1173 4.3 72.1 1.0 C A:ASP1166 4.4 24.2 1.0 C A:CYS1167 4.4 3.0 1.0 HB2 A:CYS1167 4.4 37.2 1.0 CA A:CYS1173 4.4 51.1 1.0 CA A:ASP1166 4.5 54.3 1.0 N A:MET1191 4.6 51.4 1.0 N A:VAL1169 4.6 5.1 1.0 CB A:ASP1166 4.7 42.3 1.0 O A:CYS1170 4.7 41.5 1.0 HG3 A:MET1191 4.8 37.2 1.0 HA A:CYS1173 4.8 14.2 1.0 CA A:GLY1168 4.8 61.1 1.0 HB2 A:ASN1172 4.8 37.2 1.0 OD2 A:ASP1166 4.8 11.2 1.0 C A:CYS1170 4.8 31.2 1.0 HA2 A:GLY1168 4.8 37.2 1.0 CA A:LYS1190 4.9 34.0 1.0 CB A:LYS1190 4.9 42.4 1.0 HA A:CYS1167 5.0 41.3 1.0

T.Cierpicki, L.E.Risner, J.Grembecka, S.M.Lukasik, R.Popovic, M.Omonkowska, D.D.Shultis, N.J.Zeleznik-Le, J.H.Bushweller. Structure of the Mll Cxxc Domain-Dna Complex and Its Functional Role in Mll-AF9 Leukemia. Nat.Struct.Mol.Biol. V. 17 62 2010.
ISSN: ISSN 1545-9993
PubMed: 20010842
DOI: 10.1038/NSMB.1714