Zinc in PDB 2ka4: uc(Nmr) Structure of the Cbp-TAZ1/STAT2-Tad Complex

The binding sites of Zinc atom in the uc(Nmr) Structure of the Cbp-TAZ1/STAT2-Tad Complex (pdb code 2ka4). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the uc(Nmr) Structure of the Cbp-TAZ1/STAT2-Tad Complex, PDB code: 2ka4:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in the uc(Nmr) Structure of the Cbp-TAZ1/STAT2-Tad Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of uc(Nmr) Structure of the Cbp-TAZ1/STAT2-Tad Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn440 b:6.0 occ:1.00 NE2 A:HIS362 2.1 6.0 1.0 SG A:CYS366 2.3 6.0 1.0 SG A:CYS379 2.3 6.0 1.0 SG A:CYS384 2.3 6.0 1.0 CD2 A:HIS362 2.9 6.0 1.0 HD2 A:HIS362 3.0 6.0 1.0 HB2 A:CYS366 3.1 6.0 1.0 CB A:CYS366 3.1 6.0 1.0 HZ3 A:LYS388 3.1 6.0 1.0 HH12 A:ARG369 3.1 6.0 1.0 HZ1 A:LYS388 3.2 6.0 1.0 HH11 A:ARG369 3.2 6.0 1.0 CE1 A:HIS362 3.3 6.0 1.0 HB3 A:CYS366 3.3 6.0 1.0 HB2 A:LEU381 3.4 6.0 1.0 CB A:CYS379 3.5 6.0 1.0 NH1 A:ARG369 3.6 6.0 1.0 HB2 A:CYS379 3.6 6.0 1.0 HE1 A:HIS362 3.7 6.0 1.0 NZ A:LYS388 3.7 6.0 1.0 CB A:CYS384 3.8 6.0 1.0 HB2 A:CYS384 3.8 6.0 1.0 HB3 A:CYS379 3.8 6.0 1.0 H A:LEU381 4.1 6.0 1.0 CG A:HIS362 4.1 6.0 1.0 HE3 A:LYS388 4.2 6.0 1.0 HB3 A:CYS384 4.3 6.0 1.0 H A:SER380 4.3 6.0 1.0 ND1 A:HIS362 4.3 6.0 1.0 HZ2 A:LYS388 4.4 6.0 1.0 HA A:ALA363 4.4 6.0 1.0 CB A:LEU381 4.5 6.0 1.0 CA A:CYS366 4.5 6.0 1.0 CE A:LYS388 4.6 6.0 1.0 HD23 A:LEU381 4.6 6.0 1.0 HB3 A:LEU381 4.6 6.0 1.0 HA A:CYS366 4.7 6.0 1.0 HA A:CYS384 4.7 6.0 1.0 HD3 A:ARG369 4.8 6.0 1.0 HA A:CYS379 4.8 6.0 1.0 CA A:CYS379 4.8 6.0 1.0 HG A:LEU381 4.9 6.0 1.0 CZ A:ARG369 4.9 6.0 1.0 CA A:CYS384 4.9 6.0 1.0

Zinc binding site 2 out of 3 in the uc(Nmr) Structure of the Cbp-TAZ1/STAT2-Tad Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of uc(Nmr) Structure of the Cbp-TAZ1/STAT2-Tad Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn441 b:6.0 occ:1.00 NE2 A:HIS393 2.1 6.0 1.0 SG A:CYS403 2.3 6.0 1.0 SG A:CYS397 2.3 6.0 1.0 SG A:CYS408 2.3 6.0 1.0 HH21 A:ARG412 2.8 6.0 1.0 CE1 A:HIS393 3.0 6.0 1.0 HB2 A:CYS397 3.1 6.0 1.0 CB A:CYS397 3.1 6.0 1.0 CD2 A:HIS393 3.1 6.0 1.0 CB A:CYS408 3.1 6.0 1.0 HB2 A:CYS408 3.2 6.0 1.0 HE1 A:HIS393 3.2 6.0 1.0 HB3 A:CYS408 3.2 6.0 1.0 HB2 A:CYS403 3.3 6.0 1.0 HB3 A:CYS397 3.3 6.0 1.0 HH22 A:ARG412 3.3 6.0 1.0 CB A:CYS403 3.3 6.0 1.0 HD2 A:HIS393 3.4 6.0 1.0 HB A:VAL405 3.4 6.0 1.0 NH2 A:ARG412 3.5 6.0 1.0 HB3 A:CYS403 3.7 6.0 1.0 ND1 A:HIS393 4.2 6.0 1.0 H A:VAL405 4.2 6.0 1.0 CG A:HIS393 4.2 6.0 1.0 HB1 A:ALA399 4.3 6.0 1.0 HA A:MET394 4.4 6.0 1.0 CB A:VAL405 4.5 6.0 1.0 HG22 A:VAL405 4.5 6.0 1.0 CA A:CYS397 4.5 6.0 1.0 CA A:CYS408 4.6 6.0 1.0 H A:GLY400 4.6 6.0 1.0 HG23 A:VAL405 4.6 6.0 1.0 CZ A:ARG412 4.7 6.0 1.0 CA A:CYS403 4.7 6.0 1.0 H A:ALA399 4.7 6.0 1.0 HE A:ARG412 4.7 6.0 1.0 H A:ALA409 4.7 6.0 1.0 HA A:CYS397 4.7 6.0 1.0 HA A:CYS403 4.8 6.0 1.0 CG2 A:VAL405 4.8 6.0 1.0 HG3 A:MET394 4.9 6.0 1.0

Zinc binding site 3 out of 3 in the uc(Nmr) Structure of the Cbp-TAZ1/STAT2-Tad Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of uc(Nmr) Structure of the Cbp-TAZ1/STAT2-Tad Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn442 b:6.0 occ:1.00 NE2 A:HIS417 2.1 6.0 1.0 SG A:CYS429 2.3 6.0 1.0 SG A:CYS426 2.3 6.0 1.0 SG A:CYS421 2.3 6.0 1.0 HZ1 A:LYS433 2.8 6.0 1.0 CB A:CYS421 2.9 6.0 1.0 HB3 A:CYS421 3.0 6.0 1.0 CD2 A:HIS417 3.0 6.0 1.0 HB2 A:CYS421 3.0 6.0 1.0 HD2 A:HIS417 3.1 6.0 1.0 HZ3 A:LYS433 3.1 6.0 1.0 CE1 A:HIS417 3.2 6.0 1.0 CB A:CYS426 3.4 6.0 1.0 HB2 A:CYS429 3.5 6.0 1.0 H A:CYS429 3.5 6.0 1.0 NZ A:LYS433 3.5 6.0 1.0 HB2 A:CYS426 3.5 6.0 1.0 HB3 A:CYS426 3.5 6.0 1.0 CB A:CYS429 3.5 6.0 1.0 HE1 A:HIS417 3.6 6.0 1.0 HZ2 A:LYS433 3.8 6.0 1.0 HG3 B:PRO792 3.9 6.0 1.0 CG A:HIS417 4.2 6.0 1.0 N A:CYS429 4.3 6.0 1.0 HB3 A:CYS429 4.3 6.0 1.0 ND1 A:HIS417 4.3 6.0 1.0 CA A:CYS421 4.4 6.0 1.0 HB A:VAL428 4.5 6.0 1.0 CA A:CYS429 4.5 6.0 1.0 HB3 A:ARG423 4.5 6.0 1.0 HB3 B:PRO792 4.7 6.0 1.0 HE3 A:LYS433 4.7 6.0 1.0 HA A:CYS421 4.8 6.0 1.0 CE A:LYS433 4.8 6.0 1.0 CA A:CYS426 4.8 6.0 1.0 CG B:PRO792 4.9 6.0 1.0 HA A:CYS429 4.9 6.0 1.0

J.M.Wojciak, M.A.Martinez-Yamout, H.J.Dyson, P.E.Wright. Structural Basis For Recruitment of Cbp/P300 Coactivators By STAT1 and STAT2 Transactivation Domains Embo J. V. 28 948 2009.
ISSN: ISSN 0261-4189
PubMed: 19214187
DOI: 10.1038/EMBOJ.2009.30