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Zinc in PDB 2j6e: Crystal Structure of An Autoimmune Complex Between A Human Igm Rheumatoid Factor and IGG1 Fc Reveals A Novel Fc Epitope and Evidence For Affinity Maturation

Protein crystallography data

The structure of Crystal Structure of An Autoimmune Complex Between A Human Igm Rheumatoid Factor and IGG1 Fc Reveals A Novel Fc Epitope and Evidence For Affinity Maturation, PDB code: 2j6e was solved by S.Duquerroy, E.A.Stura, S.Bressanelli, H.Browne, D.Beale, M.Hamon, P.Casali, M.C.Vaney, F.A.Rey, B.J.Sutton, M.J.Taussig, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 25.00 / 3.00
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 241.980, 75.610, 102.400, 90.00, 91.13, 90.00
R / Rfree (%) 22.3 / 28.8

Other elements in 2j6e:

The structure of Crystal Structure of An Autoimmune Complex Between A Human Igm Rheumatoid Factor and IGG1 Fc Reveals A Novel Fc Epitope and Evidence For Affinity Maturation also contains other interesting chemical elements:

Cadmium (Cd) 1 atom
Arsenic (As) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of An Autoimmune Complex Between A Human Igm Rheumatoid Factor and IGG1 Fc Reveals A Novel Fc Epitope and Evidence For Affinity Maturation (pdb code 2j6e). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of An Autoimmune Complex Between A Human Igm Rheumatoid Factor and IGG1 Fc Reveals A Novel Fc Epitope and Evidence For Affinity Maturation, PDB code: 2j6e:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 2j6e

Go back to Zinc Binding Sites List in 2j6e
Zinc binding site 1 out of 2 in the Crystal Structure of An Autoimmune Complex Between A Human Igm Rheumatoid Factor and IGG1 Fc Reveals A Novel Fc Epitope and Evidence For Affinity Maturation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of An Autoimmune Complex Between A Human Igm Rheumatoid Factor and IGG1 Fc Reveals A Novel Fc Epitope and Evidence For Affinity Maturation within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1446

b:43.7
occ:1.00
OE2 A:GLU345 1.9 37.7 1.0
NE2 A:HIS433 2.1 32.2 1.0
CD A:GLU345 2.6 37.9 1.0
OE1 A:GLU345 2.6 39.5 1.0
O1 A:CAC1447 2.7 84.5 1.0
CE1 A:HIS433 3.0 34.3 1.0
AS A:CAC1447 3.0 87.4 1.0
C2 A:CAC1447 3.0 84.8 1.0
CD2 A:HIS433 3.1 30.1 1.0
O2 A:CAC1447 3.1 83.0 1.0
ND1 A:HIS433 4.1 32.5 1.0
CG A:GLU345 4.1 35.8 1.0
CG A:HIS433 4.1 32.0 1.0
CB A:GLU345 4.6 33.1 1.0
C1 A:CAC1447 4.7 84.9 1.0

Zinc binding site 2 out of 2 in 2j6e

Go back to Zinc Binding Sites List in 2j6e
Zinc binding site 2 out of 2 in the Crystal Structure of An Autoimmune Complex Between A Human Igm Rheumatoid Factor and IGG1 Fc Reveals A Novel Fc Epitope and Evidence For Affinity Maturation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of An Autoimmune Complex Between A Human Igm Rheumatoid Factor and IGG1 Fc Reveals A Novel Fc Epitope and Evidence For Affinity Maturation within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn1446

b:1.0
occ:1.00
OE1 B:GLU294 3.0 0.8 1.0
CD2 B:HIS268 3.0 0.7 1.0
OE2 B:GLU294 3.1 0.8 1.0
CD B:GLU294 3.3 0.7 1.0
NE2 B:HIS268 3.4 0.3 1.0
CG B:HIS268 4.3 0.9 1.0
OH B:TYR300 4.3 0.6 1.0
CG B:GLU294 4.5 0.8 1.0
CE1 B:HIS268 4.7 0.5 1.0
CZ B:TYR300 4.9 0.7 1.0

Reference:

S.Duquerroy, E.A.Stura, S.Bressanelli, S.M.Fabiane, M.C.Vaney, D.Beale, M.Hamon, P.Casali, F.A.Rey, B.J.Sutton, M.J.Taussig. Crystal Structure of A Human Autoimmune Complex Between Igm Rheumatoid Factor RF61 and IGG1 Fc Reveals A Novel Epitope and Evidence For Affinity Maturation. J.Mol.Biol. V. 368 1321 2007.
ISSN: ISSN 0022-2836
PubMed: 17395205
DOI: 10.1016/J.JMB.2007.02.085
Page generated: Wed Dec 16 03:31:39 2020

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