Zinc in PDB 2h2g: The Structural Basis of Sirtuin Substrate Affinity

The structure of The Structural Basis of Sirtuin Substrate Affinity, PDB code: 2h2g was solved by M.S.Cosgrove, C.Wolberger, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	8.00 / 1.63
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	46.223, 58.149, 109.062, 90.00, 90.00, 90.00
R / Rfree (%)	19.8 / 22.6

The binding sites of Zinc atom in the The Structural Basis of Sirtuin Substrate Affinity (pdb code 2h2g). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the The Structural Basis of Sirtuin Substrate Affinity, PDB code: 2h2g:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the The Structural Basis of Sirtuin Substrate Affinity


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of The Structural Basis of Sirtuin Substrate Affinity within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1001 b:18.2 occ:1.00 SG A:CYS127 2.3 21.2 1.0 SG A:CYS151 2.4 18.9 1.0 SG A:CYS124 2.4 15.7 1.0 SG A:CYS148 2.4 18.3 1.0 CB A:CYS148 3.1 15.6 1.0 CB A:CYS124 3.1 15.0 1.0 CB A:CYS127 3.4 20.9 1.0 CB A:CYS151 3.6 20.2 1.0 N A:CYS127 3.8 20.2 1.0 N A:CYS151 3.8 22.6 1.0 CA A:CYS127 4.1 20.6 1.0 CA A:CYS151 4.2 21.1 1.0 CB A:ASP150 4.6 25.0 1.0 CB A:SER153 4.6 18.2 1.0 CA A:CYS124 4.6 13.9 1.0 CA A:CYS148 4.6 17.8 1.0 CB A:LYS129 4.6 20.2 1.0 CB A:ARG126 4.6 20.5 1.0 N A:SER153 4.8 18.3 1.0 C A:CYS127 4.8 21.1 1.0 C A:CYS151 4.8 21.3 1.0 C A:ASP150 4.8 24.6 1.0 N A:GLU128 4.8 20.0 1.0 O A:HOH1133 4.8 33.9 1.0 N A:ASN152 4.9 20.7 1.0 C A:ARG126 4.9 20.1 1.0 N A:LYS129 4.9 19.4 1.0 OG A:SER153 5.0 18.4 1.0

Zinc binding site 2 out of 2 in the The Structural Basis of Sirtuin Substrate Affinity


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of The Structural Basis of Sirtuin Substrate Affinity within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1002 b:25.2 occ:1.00 ND1 A:HIS56 2.4 23.1 1.0 OE2 A:GLU58 2.4 28.6 1.0 O A:HOH1134 2.4 43.0 1.0 CD A:GLU58 3.0 23.8 1.0 OE1 A:GLU58 3.2 22.9 1.0 CE1 A:HIS56 3.3 22.8 1.0 CG A:HIS56 3.4 20.2 1.0 CB A:HIS56 3.7 17.9 1.0 CA A:HIS56 3.8 16.3 1.0 O A:SER55 3.9 18.4 1.0 O A:HOH1221 4.1 43.5 1.0 CG A:GLU58 4.3 21.5 1.0 NE2 A:HIS56 4.4 21.6 1.0 CD2 A:HIS56 4.5 20.7 1.0 C A:SER55 4.7 15.8 1.0 N A:HIS56 4.7 16.3 1.0 CG A:GLU59 4.8 28.9 1.0 C A:HIS56 4.8 16.3 1.0

M.S.Cosgrove, K.Bever, J.L.Avalos, S.Muhammad, X.Zhang, C.Wolberger. The Structural Basis of Sirtuin Substrate Affinity Biochemistry V. 45 7511 2006.
ISSN: ISSN 0006-2960
PubMed: 16768447
DOI: 10.1021/BI0526332