Zinc in PDB 2gfe: Crystal Structure of the GLUR2 A476E S673D Ligand Binding Core Mutant at 1.54 Angstroms Resolution

The structure of Crystal Structure of the GLUR2 A476E S673D Ligand Binding Core Mutant at 1.54 Angstroms Resolution, PDB code: 2gfe was solved by M.L.Mayer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	39.42 / 1.54
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	114.318, 163.301, 47.557, 90.00, 90.00, 90.00
R / Rfree (%)	21.3 / 22.7

The binding sites of Zinc atom in the Crystal Structure of the GLUR2 A476E S673D Ligand Binding Core Mutant at 1.54 Angstroms Resolution (pdb code 2gfe). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 5 binding sites of Zinc where determined in the Crystal Structure of the GLUR2 A476E S673D Ligand Binding Core Mutant at 1.54 Angstroms Resolution, PDB code: 2gfe:
Jump to Zinc binding site number: 1; 2; 3; 4; 5;

Zinc binding site 1 out of 5 in the Crystal Structure of the GLUR2 A476E S673D Ligand Binding Core Mutant at 1.54 Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the GLUR2 A476E S673D Ligand Binding Core Mutant at 1.54 Angstroms Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn869 b:14.2 occ:1.00 OE1 A:GLU42 2.0 12.8 1.0 NE2 A:HIS46 2.1 12.1 1.0 OE2 B:GLU166 2.1 17.6 1.0 O A:HOH1250 2.2 14.8 1.0 OE1 B:GLU166 2.7 17.5 1.0 CD B:GLU166 2.7 14.6 1.0 CD A:GLU42 3.0 14.7 1.0 CD2 A:HIS46 3.1 13.1 1.0 CE1 A:HIS46 3.1 15.3 1.0 OE2 A:GLU42 3.3 14.0 1.0 CD2 A:LEU241 4.0 16.6 1.0 ND1 A:HIS46 4.2 14.2 1.0 O B:HOH1184 4.2 36.1 1.0 CG A:HIS46 4.2 13.0 1.0 CG B:GLU166 4.2 14.5 1.0 CG A:GLU42 4.3 10.5 1.0 N B:SER168 4.3 12.5 1.0 CB A:GLU42 4.7 10.7 1.0 O B:ALA165 4.8 12.9 1.0 CB B:GLU166 4.8 15.4 1.0 CB B:SER168 4.9 12.7 1.0 CA B:PRO167 4.9 12.6 1.0 CA B:SER168 4.9 12.3 1.0 CD2 A:LEU246 4.9 21.0 1.0 C B:PRO167 4.9 12.0 1.0 CA B:GLU166 5.0 14.9 1.0

Zinc binding site 2 out of 5 in the Crystal Structure of the GLUR2 A476E S673D Ligand Binding Core Mutant at 1.54 Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of the GLUR2 A476E S673D Ligand Binding Core Mutant at 1.54 Angstroms Resolution within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn870 b:19.2 occ:1.00 NE2 B:HIS23 2.1 18.9 1.0 OE2 B:GLU30 2.2 19.1 1.0 CD B:GLU30 2.8 18.3 1.0 OE1 B:GLU30 2.8 19.7 1.0 CD2 B:HIS23 3.0 18.6 1.0 CE1 B:HIS23 3.2 16.2 1.0 CD B:LYS20 4.0 17.0 1.0 NZ B:LYS20 4.1 20.4 1.0 CG B:HIS23 4.2 19.2 1.0 ND1 B:HIS23 4.2 18.7 1.0 CG B:GLU30 4.3 18.9 1.0 O B:GLU30 4.3 16.0 1.0 CD1 B:LEU26 4.6 34.4 1.0 CE B:LYS20 4.7 17.7 1.0

Zinc binding site 3 out of 5 in the Crystal Structure of the GLUR2 A476E S673D Ligand Binding Core Mutant at 1.54 Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of the GLUR2 A476E S673D Ligand Binding Core Mutant at 1.54 Angstroms Resolution within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn872 b:15.1 occ:1.00 OE1 B:GLU42 2.1 11.9 1.0 NE2 B:HIS46 2.1 15.2 1.0 O B:HOH1295 2.2 16.8 1.0 CD B:GLU42 2.9 13.7 1.0 CD2 B:HIS46 3.0 13.7 1.0 CE1 B:HIS46 3.1 14.1 1.0 OE2 B:GLU42 3.2 17.5 1.0 CD2 B:LEU241 3.6 14.3 1.0 O B:HOH1190 3.8 35.0 1.0 OE1 B:GLN244 3.8 31.7 1.0 NZ B:LYS45 3.9 14.3 1.0 CE B:LYS45 3.9 14.7 1.0 ND1 B:HIS46 4.2 14.7 1.0 CG B:HIS46 4.2 13.0 1.0 CG B:GLU42 4.3 12.2 1.0 CB B:GLU42 4.7 9.8 1.0 CD B:GLN244 4.7 28.1 1.0 NE2 B:GLN244 4.8 30.7 1.0

Zinc binding site 4 out of 5 in the Crystal Structure of the GLUR2 A476E S673D Ligand Binding Core Mutant at 1.54 Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Crystal Structure of the GLUR2 A476E S673D Ligand Binding Core Mutant at 1.54 Angstroms Resolution within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn871 b:22.7 occ:1.00 OD2 C:ASP65 2.1 17.6 1.0 O C:HOH1192 2.3 29.8 1.0 O C:HOH1141 2.5 32.5 1.0 CG C:ASP65 2.8 21.5 1.0 OD1 C:ASP65 2.9 22.6 1.0 OD2 C:ASP67 4.0 33.8 1.0 O C:HOH1188 4.1 40.4 1.0 CB C:ASP65 4.3 19.5 1.0 CB C:ASP67 4.4 31.2 1.0 CG C:ASP67 4.7 32.9 1.0 CG2 C:THR68 4.8 25.9 1.0

Zinc binding site 5 out of 5 in the Crystal Structure of the GLUR2 A476E S673D Ligand Binding Core Mutant at 1.54 Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Crystal Structure of the GLUR2 A476E S673D Ligand Binding Core Mutant at 1.54 Angstroms Resolution within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn873 b:49.5 occ:1.00 NE2 C:HIS46 2.5 31.0 1.0 OE1 C:GLU42 2.5 25.1 1.0 CE1 C:HIS46 3.4 30.3 1.0 CD2 C:HIS46 3.4 30.0 1.0 CD C:GLU42 3.5 25.4 1.0 CD2 C:LEU241 3.9 16.5 1.0 OE2 C:GLU42 3.9 27.9 1.0 OE1 C:GLN244 3.9 35.6 1.0 ND1 C:HIS46 4.5 30.3 1.0 CG C:HIS46 4.6 29.1 1.0 CD C:LYS45 4.7 31.5 1.0 CG C:GLU42 4.7 23.1 1.0 CD C:GLN244 4.9 33.1 1.0 CB C:GLU42 4.9 18.2 1.0

M.C.Weston, C.Gertler, M.L.Mayer, C.Rosenmund. Interdomain Interactions in Ampa and Kainate Receptors Regulate Affinity For Glutamate. J.Neurosci. V. 26 7650 2006.
ISSN: ISSN 0270-6474
PubMed: 16855092
DOI: 10.1523/JNEUROSCI.1519-06.2006