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Zinc in PDB 2fmz: Carbonic Anhydrase Activators. Activation of Isoforms I, II, IV, Va, VII and Xiv with L- and D- Phenylalanine, Structure with D- Phenylalanine.

Enzymatic activity of Carbonic Anhydrase Activators. Activation of Isoforms I, II, IV, Va, VII and Xiv with L- and D- Phenylalanine, Structure with D- Phenylalanine.

All present enzymatic activity of Carbonic Anhydrase Activators. Activation of Isoforms I, II, IV, Va, VII and Xiv with L- and D- Phenylalanine, Structure with D- Phenylalanine.:
4.2.1.1;

Protein crystallography data

The structure of Carbonic Anhydrase Activators. Activation of Isoforms I, II, IV, Va, VII and Xiv with L- and D- Phenylalanine, Structure with D- Phenylalanine., PDB code: 2fmz was solved by C.Temperini, A.Scozzafava, D.Vullo, C.T.Supuran, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 14.35 / 1.60
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 42.090, 41.380, 72.100, 90.00, 104.40, 90.00
R / Rfree (%) 21.8 / 23.7

Other elements in 2fmz:

The structure of Carbonic Anhydrase Activators. Activation of Isoforms I, II, IV, Va, VII and Xiv with L- and D- Phenylalanine, Structure with D- Phenylalanine. also contains other interesting chemical elements:

Mercury (Hg) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Carbonic Anhydrase Activators. Activation of Isoforms I, II, IV, Va, VII and Xiv with L- and D- Phenylalanine, Structure with D- Phenylalanine. (pdb code 2fmz). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Carbonic Anhydrase Activators. Activation of Isoforms I, II, IV, Va, VII and Xiv with L- and D- Phenylalanine, Structure with D- Phenylalanine., PDB code: 2fmz:

Zinc binding site 1 out of 1 in 2fmz

Go back to Zinc Binding Sites List in 2fmz
Zinc binding site 1 out of 1 in the Carbonic Anhydrase Activators. Activation of Isoforms I, II, IV, Va, VII and Xiv with L- and D- Phenylalanine, Structure with D- Phenylalanine.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Carbonic Anhydrase Activators. Activation of Isoforms I, II, IV, Va, VII and Xiv with L- and D- Phenylalanine, Structure with D- Phenylalanine. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn262

b:5.5
occ:1.00
 NE2 A:HIS96 2.1 3.7 1.0
ND1 A:HIS119 2.1 1.0 1.0
NE2 A:HIS94 2.1 3.5 1.0
O A:HOH438 2.3 1.4 0.5
CE1 A:HIS119 2.9 1.0 1.0
CD2 A:HIS96 2.9 3.1 1.0
CD2 A:HIS94 3.0 3.2 1.0
CE1 A:HIS96 3.1 4.8 1.0
CE1 A:HIS94 3.1 4.1 1.0
CG A:HIS119 3.2 1.6 1.0
CB A:HIS119 3.6 2.2 1.0
OG1 A:THR199 3.7 2.0 1.0
O A:HOH423 3.7 11.8 1.0
OE1 A:GLU106 4.0 2.7 1.0
NE2 A:HIS119 4.1 1.0 1.0
CG A:HIS96 4.1 2.8 1.0
CG A:HIS94 4.2 3.5 1.0
ND1 A:HIS96 4.2 4.8 1.0
ND1 A:HIS94 4.2 2.0 1.0
CD2 A:HIS119 4.2 2.4 1.0
O A:HOH424 4.3 17.8 1.0
CD A:GLU106 4.9 4.2 1.0
O A:HOH454 4.9 28.7 1.0
CB A:THR199 5.0 2.3 1.0

Reference:

C.Temperini, A.Scozzafava, D.Vullo, C.T.Supuran. Carbonic Anhydrase Activators. Activation of Isoforms I, II, IV, Va, VII, and Xiv with L- and D-Phenylalanine and Crystallographic Analysis of Their Adducts with Isozyme II: Stereospecific Recognition Within the Active Site of An Enzyme and Its Consequences For the Drug Design. J.Med.Chem. V. 49 3019 2006.
ISSN: ISSN 0022-2623
PubMed: 16686544
DOI: 10.1021/JM0603320
Page generated: Wed Dec 16 03:28:25 2020

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