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Zinc in PDB 2fgn: Structural Studies Examining the Substrate Specificity Profiles of Pc- Plcbc Protein Variants

Enzymatic activity of Structural Studies Examining the Substrate Specificity Profiles of Pc- Plcbc Protein Variants

All present enzymatic activity of Structural Studies Examining the Substrate Specificity Profiles of Pc- Plcbc Protein Variants:
3.1.4.3;

Protein crystallography data

The structure of Structural Studies Examining the Substrate Specificity Profiles of Pc- Plcbc Protein Variants, PDB code: 2fgn was solved by A.P.Benfield, S.F.Martin, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 2.04
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 90.522, 90.522, 70.214, 90.00, 90.00, 90.00
R / Rfree (%) 17.9 / 20.6

Zinc Binding Sites:

The binding sites of Zinc atom in the Structural Studies Examining the Substrate Specificity Profiles of Pc- Plcbc Protein Variants (pdb code 2fgn). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Structural Studies Examining the Substrate Specificity Profiles of Pc- Plcbc Protein Variants, PDB code: 2fgn:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in 2fgn

Go back to Zinc Binding Sites List in 2fgn
Zinc binding site 1 out of 3 in the Structural Studies Examining the Substrate Specificity Profiles of Pc- Plcbc Protein Variants


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structural Studies Examining the Substrate Specificity Profiles of Pc- Plcbc Protein Variants within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn246

b:15.0
occ:1.00
O A:HOH1993 2.1 10.3 1.0
NE2 A:HIS118 2.2 8.5 1.0
OD2 A:ASP122 2.2 11.1 1.0
ND1 A:HIS69 2.3 9.2 1.0
OD1 A:ASP55 2.4 9.3 1.0
CE1 A:HIS69 3.1 9.7 1.0
CD2 A:HIS118 3.1 7.8 1.0
CG A:ASP122 3.2 12.0 1.0
CG A:ASP55 3.2 13.1 1.0
CE1 A:HIS118 3.2 8.2 1.0
ZN A:ZN248 3.3 13.4 1.0
OD2 A:ASP55 3.3 12.2 1.0
CG A:HIS69 3.4 8.2 1.0
OD1 A:ASP122 3.4 6.9 1.0
O A:HOH2142 3.4 35.6 1.0
CB A:HIS69 3.8 8.7 1.0
NE2 A:HIS14 4.0 11.9 1.0
NE2 A:HIS69 4.3 11.3 1.0
CG A:HIS118 4.3 9.0 1.0
O A:HOH1994 4.3 17.0 1.0
ND1 A:HIS118 4.3 9.1 1.0
CD2 A:HIS69 4.4 8.3 1.0
CB A:ASP122 4.5 10.2 1.0
CE1 A:HIS14 4.6 10.9 1.0
CB A:ASP55 4.6 12.0 1.0
CE1 A:HIS128 4.7 11.6 1.0
CD2 A:HIS14 4.8 9.2 1.0
O A:TRP1 4.8 9.9 1.0
CB A:ALA54 5.0 7.5 1.0

Zinc binding site 2 out of 3 in 2fgn

Go back to Zinc Binding Sites List in 2fgn
Zinc binding site 2 out of 3 in the Structural Studies Examining the Substrate Specificity Profiles of Pc- Plcbc Protein Variants


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structural Studies Examining the Substrate Specificity Profiles of Pc- Plcbc Protein Variants within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn247

b:15.0
occ:0.80
NE2 A:HIS128 2.1 9.3 1.0
NE2 A:HIS142 2.2 12.5 1.0
O A:HOH1994 2.3 17.0 1.0
OE2 A:GLU146 2.4 13.1 1.0
O A:HOH1995 2.5 33.6 1.0
OE1 A:GLU146 2.5 17.4 1.0
CD A:GLU146 2.7 15.0 1.0
CE1 A:HIS142 3.1 12.4 1.0
CE1 A:HIS128 3.1 11.6 1.0
CD2 A:HIS128 3.2 10.0 1.0
CD2 A:HIS142 3.2 9.5 1.0
O A:HOH2142 4.0 35.6 1.0
N A:TRP1 4.0 8.7 1.0
CG A:GLU146 4.1 14.8 1.0
ND1 A:HIS128 4.2 11.3 1.0
ND1 A:HIS142 4.2 12.1 1.0
CG A:HIS128 4.3 9.9 1.0
CG A:HIS142 4.3 11.8 1.0
O A:HOH2003 4.4 30.6 1.0
OE1 A:GLN125 4.5 13.3 1.0
O A:HOH1993 4.5 10.3 1.0
ZN A:ZN248 4.7 13.4 1.0
O A:HOH1998 4.8 38.2 1.0
O A:HOH2000 4.9 26.9 1.0
CA A:TRP1 4.9 9.4 1.0
CZ A:PHE70 5.0 9.8 1.0
O A:TRP1 5.0 9.9 1.0

Zinc binding site 3 out of 3 in 2fgn

Go back to Zinc Binding Sites List in 2fgn
Zinc binding site 3 out of 3 in the Structural Studies Examining the Substrate Specificity Profiles of Pc- Plcbc Protein Variants


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Structural Studies Examining the Substrate Specificity Profiles of Pc- Plcbc Protein Variants within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn248

b:13.4
occ:1.00
O A:HOH1993 2.1 10.3 1.0
NE2 A:HIS14 2.1 11.9 1.0
OD1 A:ASP122 2.2 6.9 1.0
O A:TRP1 2.3 9.9 1.0
N A:TRP1 2.3 8.7 1.0
C A:TRP1 3.0 11.0 1.0
CD2 A:HIS14 3.0 9.2 1.0
CA A:TRP1 3.1 9.4 1.0
O A:HOH1994 3.1 17.0 1.0
CG A:ASP122 3.2 12.0 1.0
CE1 A:HIS14 3.2 10.9 1.0
ZN A:ZN246 3.3 15.0 1.0
OD2 A:ASP122 3.5 11.1 1.0
CB A:TRP1 3.7 8.8 1.0
NE2 A:HIS118 3.9 8.5 1.0
OD2 A:ASP55 4.0 12.2 1.0
CG A:HIS14 4.2 10.6 1.0
ND1 A:HIS14 4.2 9.8 1.0
N A:SER2 4.3 11.2 1.0
CE1 A:HIS118 4.3 8.2 1.0
CG A:TRP1 4.4 10.5 1.0
CE1 A:HIS128 4.5 11.6 1.0
CB A:ASP122 4.5 10.2 1.0
NE2 A:HIS128 4.5 9.3 1.0
CD1 A:TRP1 4.5 10.2 1.0
O A:HOH2142 4.5 35.6 1.0
OE2 A:GLU146 4.6 13.1 1.0
ZN A:ZN247 4.7 15.0 0.8
CA A:ASP122 4.7 11.4 1.0
CD2 A:HIS118 4.8 7.8 1.0
OD1 A:ASP55 4.8 9.3 1.0
CG A:ASP55 4.8 13.1 1.0

Reference:

A.P.Benfield, N.M.Goodey, L.T.Phillips, S.F.Martin. Structural Studies Examining the Substrate Specificity Profiles of Pc-Plc(Bc) Protein Variants. Arch.Biochem.Biophys. V. 460 41 2007.
ISSN: ISSN 0003-9861
PubMed: 17324372
DOI: 10.1016/J.ABB.2007.01.023
Page generated: Wed Oct 16 23:46:11 2024

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