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Zinc in PDB 2ez7: Carbonic Anhydrase Activators. Activation of Isozymes I, II, IV, Va, VII and Xiv with L- and D-Histidine and Crystallographic Analysis of Their Adducts with Isoform II: Engineering Proton Transfer Processes Within the Active Site of An Enzyme

Enzymatic activity of Carbonic Anhydrase Activators. Activation of Isozymes I, II, IV, Va, VII and Xiv with L- and D-Histidine and Crystallographic Analysis of Their Adducts with Isoform II: Engineering Proton Transfer Processes Within the Active Site of An Enzyme

All present enzymatic activity of Carbonic Anhydrase Activators. Activation of Isozymes I, II, IV, Va, VII and Xiv with L- and D-Histidine and Crystallographic Analysis of Their Adducts with Isoform II: Engineering Proton Transfer Processes Within the Active Site of An Enzyme:
4.2.1.1;

Protein crystallography data

The structure of Carbonic Anhydrase Activators. Activation of Isozymes I, II, IV, Va, VII and Xiv with L- and D-Histidine and Crystallographic Analysis of Their Adducts with Isoform II: Engineering Proton Transfer Processes Within the Active Site of An Enzyme, PDB code: 2ez7 was solved by C.Temperini, A.Scozzafava, D.Vullo, C.T.Supuran, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 8.00 / 2.00
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 42.060, 41.430, 72.520, 90.00, 104.40, 90.00
R / Rfree (%) 24.9 / 30

Other elements in 2ez7:

The structure of Carbonic Anhydrase Activators. Activation of Isozymes I, II, IV, Va, VII and Xiv with L- and D-Histidine and Crystallographic Analysis of Their Adducts with Isoform II: Engineering Proton Transfer Processes Within the Active Site of An Enzyme also contains other interesting chemical elements:

Mercury (Hg) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Carbonic Anhydrase Activators. Activation of Isozymes I, II, IV, Va, VII and Xiv with L- and D-Histidine and Crystallographic Analysis of Their Adducts with Isoform II: Engineering Proton Transfer Processes Within the Active Site of An Enzyme (pdb code 2ez7). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Carbonic Anhydrase Activators. Activation of Isozymes I, II, IV, Va, VII and Xiv with L- and D-Histidine and Crystallographic Analysis of Their Adducts with Isoform II: Engineering Proton Transfer Processes Within the Active Site of An Enzyme, PDB code: 2ez7:

Zinc binding site 1 out of 1 in 2ez7

Go back to Zinc Binding Sites List in 2ez7
Zinc binding site 1 out of 1 in the Carbonic Anhydrase Activators. Activation of Isozymes I, II, IV, Va, VII and Xiv with L- and D-Histidine and Crystallographic Analysis of Their Adducts with Isoform II: Engineering Proton Transfer Processes Within the Active Site of An Enzyme


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Carbonic Anhydrase Activators. Activation of Isozymes I, II, IV, Va, VII and Xiv with L- and D-Histidine and Crystallographic Analysis of Their Adducts with Isoform II: Engineering Proton Transfer Processes Within the Active Site of An Enzyme within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn262

b:8.8
occ:1.00
 NE2 A:HIS96 2.1 1.0 1.0
ND1 A:HIS119 2.2 3.5 1.0
NE2 A:HIS94 2.3 9.0 1.0
O A:HOH603 2.3 1.0 1.0
CD2 A:HIS96 3.0 1.8 1.0
CE1 A:HIS119 3.0 5.1 1.0
CD2 A:HIS94 3.1 5.3 1.0
CE1 A:HIS96 3.2 1.5 1.0
CG A:HIS119 3.3 5.5 1.0
CE1 A:HIS94 3.3 7.0 1.0
OG1 A:THR199 3.5 1.0 1.0
OE1 A:GLU106 3.6 6.0 1.0
CB A:HIS119 3.7 1.2 1.0
O A:HOH598 4.0 16.0 1.0
CG A:HIS96 4.2 1.5 1.0
ND1 A:HIS96 4.2 1.0 1.0
NE2 A:HIS119 4.2 3.9 1.0
CG A:HIS94 4.3 4.6 1.0
CD2 A:HIS119 4.4 3.0 1.0
ND1 A:HIS94 4.4 8.2 1.0
O A:HOH583 4.5 15.5 1.0
CD A:GLU106 4.6 4.0 1.0
CB A:THR199 4.9 3.9 1.0
CH2 A:TRP209 5.0 4.1 1.0

Reference:

C.Temperini, A.Scozzafava, D.Vullo, C.T.Supuran. Carbonic Anhydrase Activators. Activation of Isozymes I, II, IV, Va, VII, and Xiv with L- and D-Histidine and Crystallographic Analysis of Their Adducts with Isoform II: Engineering Proton-Transfer Processes Within the Active Site of An Enzyme. Chemistry V. 12 7057 2006.
ISSN: ISSN 0947-6539
PubMed: 16807956
DOI: 10.1002/CHEM.200600159
Page generated: Wed Oct 16 23:36:22 2024

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