Zinc in PDB 2cki: Structure of Ulilysin, A Member of the Pappalysin Family of Metzincin Metalloendopeptidases.

The structure of Structure of Ulilysin, A Member of the Pappalysin Family of Metzincin Metalloendopeptidases., PDB code: 2cki was solved by C.Tallant, R.Garcia-Castellanos, J.Seco, U.Baumann, F.X.Gomis-Ruth, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	39.00 / 1.70
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	49.564, 126.148, 87.406, 90.00, 90.00, 90.00
R / Rfree (%)	17.3 / 24.1

The structure of Structure of Ulilysin, A Member of the Pappalysin Family of Metzincin Metalloendopeptidases. also contains other interesting chemical elements:

Calcium

(Ca)

5 atoms

The binding sites of Zinc atom in the Structure of Ulilysin, A Member of the Pappalysin Family of Metzincin Metalloendopeptidases. (pdb code 2cki). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of Ulilysin, A Member of the Pappalysin Family of Metzincin Metalloendopeptidases., PDB code: 2cki:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Structure of Ulilysin, A Member of the Pappalysin Family of Metzincin Metalloendopeptidases.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Ulilysin, A Member of the Pappalysin Family of Metzincin Metalloendopeptidases. within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn999 b:15.9 occ:1.00 NE2 A:HIS238 2.0 14.9 1.0 NE2 A:HIS228 2.0 14.9 1.0 NE2 A:HIS232 2.1 15.4 1.0 O A:HOH2301 2.1 11.6 1.0 CD2 A:HIS238 3.0 14.1 1.0 CD2 A:HIS228 3.0 15.2 1.0 CE1 A:HIS238 3.0 16.5 1.0 CE1 A:HIS232 3.0 15.5 1.0 CE1 A:HIS228 3.0 14.2 1.0 CD2 A:HIS232 3.1 15.2 1.0 CE1 A:TYR292 3.8 19.1 1.0 OH A:TYR292 4.0 20.7 1.0 ND1 A:HIS238 4.1 14.0 1.0 CG A:HIS238 4.1 14.8 1.0 ND1 A:HIS228 4.1 16.8 1.0 CG A:HIS228 4.1 17.2 1.0 ND1 A:HIS232 4.1 13.3 1.0 CG A:HIS232 4.2 14.9 1.0 CZ A:TYR292 4.4 20.0 1.0 OE1 A:GLU229 4.5 21.5 1.0 O A:HOH2129 4.5 15.3 1.0 O A:HOH2182 4.6 16.9 1.0 OE2 A:GLU229 4.6 24.0 1.0 N A:ARG401 4.6 25.8 0.5 CA A:ARG401 4.7 25.2 0.5 CE A:MSE290 4.7 13.5 1.0 CD1 A:TYR292 4.8 19.4 1.0 CD A:GLU229 4.8 19.5 1.0

Zinc binding site 2 out of 2 in the Structure of Ulilysin, A Member of the Pappalysin Family of Metzincin Metalloendopeptidases.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of Ulilysin, A Member of the Pappalysin Family of Metzincin Metalloendopeptidases. within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn999 b:16.4 occ:1.00 NE2 B:HIS238 2.0 15.0 1.0 NE2 B:HIS228 2.0 14.9 1.0 NE2 B:HIS232 2.1 17.5 1.0 O B:HOH2289 2.1 14.3 1.0 CD2 B:HIS238 3.0 14.2 1.0 CE1 B:HIS238 3.0 16.7 1.0 CD2 B:HIS228 3.0 15.0 1.0 CE1 B:HIS228 3.0 16.5 1.0 CE1 B:HIS232 3.0 15.6 1.0 CD2 B:HIS232 3.1 16.4 1.0 CE1 B:TYR292 3.8 21.1 1.0 OH B:TYR292 4.0 23.0 1.0 ND1 B:HIS238 4.1 16.1 1.0 CG B:HIS238 4.1 14.6 1.0 ND1 B:HIS228 4.1 16.8 1.0 CG B:HIS228 4.1 16.7 1.0 ND1 B:HIS232 4.2 15.2 1.0 CG B:HIS232 4.2 14.8 1.0 CZ B:TYR292 4.4 20.7 1.0 O B:HOH2118 4.5 17.9 1.0 OE1 B:GLU229 4.5 23.9 1.0 N B:ARG401 4.5 25.7 0.5 O B:HOH2172 4.5 19.9 1.0 OE2 B:GLU229 4.6 25.0 1.0 CA B:ARG401 4.7 25.2 0.5 CE B:MSE290 4.7 16.7 1.0 CD B:GLU229 4.8 20.5 1.0 O B:HOH2287 4.8 48.3 1.0 CD1 B:TYR292 4.8 18.1 1.0

C.Tallant, R.Garcia-Castellanos, J.Seco, U.Baumann, F.X.Gomis-Ruth. Molecular Analysis of Ulilysin, the Structural Prototype of A New Family of Metzincin Metalloproteases. J.Biol.Chem. V. 281 17920 2006.
ISSN: ISSN 0021-9258
PubMed: 16627477
DOI: 10.1074/JBC.M600907200