Zinc in PDB 2c7a: Structure of the Progesterone Receptor-Dna Complex

The structure of Structure of the Progesterone Receptor-Dna Complex, PDB code: 2c7a was solved by S.C.Roemer, D.C.Donham, L.Sherman, V.H.Pon, D.P.Edwards, M.E.A.Churchill, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.00 / 2.5
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	39.530, 107.850, 111.960, 90.00, 90.00, 90.00
R / Rfree (%)	19.8 / 24.6

The binding sites of Zinc atom in the Structure of the Progesterone Receptor-Dna Complex (pdb code 2c7a). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Structure of the Progesterone Receptor-Dna Complex, PDB code: 2c7a:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Structure of the Progesterone Receptor-Dna Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of the Progesterone Receptor-Dna Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1641 b:34.1 occ:1.00 SG A:CYS570 2.3 31.6 1.0 SG A:CYS567 2.3 35.1 1.0 SG A:CYS587 2.3 31.3 1.0 SG A:CYS584 2.3 32.5 1.0 CB A:CYS567 3.3 37.0 1.0 CB A:CYS587 3.3 31.4 1.0 CB A:CYS570 3.4 33.3 1.0 CB A:CYS584 3.4 33.3 1.0 N A:CYS570 3.7 32.3 1.0 N A:CYS584 3.9 33.3 1.0 CA A:CYS570 4.1 33.8 1.0 N A:CYS587 4.2 31.2 1.0 CA A:CYS584 4.2 33.7 1.0 OG A:SER586 4.2 31.8 1.0 NH1 A:ARG616 4.3 35.5 1.0 CA A:CYS587 4.4 31.6 1.0 CB A:ILE569 4.4 31.9 1.0 CB A:ASP572 4.5 41.8 1.0 C A:ILE569 4.7 32.5 1.0 C A:CYS570 4.7 35.2 1.0 CA A:CYS567 4.7 37.5 1.0 O A:CYS584 4.7 34.3 1.0 C A:CYS584 4.8 34.3 1.0 N A:GLY571 4.8 36.5 1.0 NH2 A:ARG623 4.8 35.6 1.0 N A:ASP572 4.9 39.8 1.0 CD A:ARG616 4.9 33.2 1.0 CA A:ILE569 4.9 31.9 1.0 N A:ILE569 5.0 32.7 1.0 CB A:THR583 5.0 33.0 1.0

Zinc binding site 2 out of 4 in the Structure of the Progesterone Receptor-Dna Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of the Progesterone Receptor-Dna Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1642 b:27.0 occ:1.00 SG A:CYS619 2.3 29.6 1.0 SG A:CYS622 2.3 22.7 1.0 SG A:CYS603 2.3 27.1 1.0 SG A:CYS609 2.3 25.3 1.0 CB A:CYS603 3.2 27.7 1.0 CB A:CYS609 3.2 25.6 1.0 CB A:CYS622 3.3 26.1 1.0 CB A:CYS619 3.4 27.8 1.0 O A:HOH2026 4.0 23.2 1.0 CA A:CYS603 4.0 28.2 1.0 N A:CYS609 4.0 25.4 1.0 N A:CYS622 4.1 26.4 1.0 CA A:CYS609 4.2 25.4 1.0 O A:HOH2024 4.3 30.4 1.0 CA A:CYS622 4.3 26.3 1.0 O A:HOH2029 4.4 25.7 1.0 CA A:ASN607 4.5 29.6 1.0 N A:ASN607 4.5 29.0 1.0 O B:HOH2007 4.5 23.9 1.0 N A:ASP608 4.6 28.8 1.0 C A:CYS603 4.8 29.0 1.0 CA A:CYS619 4.8 28.2 1.0 C A:ASN607 4.9 29.2 1.0 O A:CYS619 4.9 28.3 1.0 N A:ALA604 4.9 29.2 1.0 N A:GLY605 4.9 28.6 1.0 CB A:ALA621 5.0 24.1 1.0

Zinc binding site 3 out of 4 in the Structure of the Progesterone Receptor-Dna Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Structure of the Progesterone Receptor-Dna Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1639 b:37.5 occ:1.00 SG B:CYS570 2.3 37.0 1.0 SG B:CYS587 2.3 34.9 1.0 SG B:CYS584 2.3 37.8 1.0 SG B:CYS567 2.3 38.8 1.0 CB B:CYS570 3.3 36.1 1.0 CB B:CYS587 3.3 35.4 1.0 CB B:CYS567 3.4 42.1 1.0 CB B:CYS584 3.4 38.5 1.0 N B:CYS570 3.7 35.2 1.0 N B:CYS584 3.9 40.3 1.0 CA B:CYS570 4.0 35.8 1.0 N B:CYS587 4.1 35.4 1.0 CA B:CYS584 4.3 39.5 1.0 CB B:ILE569 4.3 34.5 1.0 CA B:CYS587 4.4 35.6 1.0 OG B:SER586 4.4 34.3 1.0 CB B:ASP572 4.5 43.1 1.0 NH1 B:ARG616 4.6 33.2 1.0 C B:ILE569 4.7 35.8 1.0 C B:CYS570 4.8 36.2 1.0 N B:GLY571 4.8 37.5 1.0 NH2 B:ARG623 4.8 35.1 1.0 CA B:CYS567 4.9 42.5 1.0 C B:CYS584 4.9 39.4 1.0 CA B:ILE569 4.9 35.1 1.0 N B:ASP572 4.9 41.0 1.0 O B:CYS584 4.9 39.7 1.0 CG1 B:ILE569 5.0 32.7 1.0

Zinc binding site 4 out of 4 in the Structure of the Progesterone Receptor-Dna Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Structure of the Progesterone Receptor-Dna Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1640 b:30.2 occ:1.00 SG B:CYS609 2.3 27.0 1.0 SG B:CYS603 2.3 29.1 1.0 SG B:CYS622 2.3 28.3 1.0 SG B:CYS619 2.3 29.4 1.0 CB B:CYS603 3.3 28.8 1.0 CB B:CYS609 3.3 30.7 1.0 CB B:CYS619 3.3 28.4 1.0 CB B:CYS622 3.4 29.8 1.0 CA B:CYS603 4.0 30.4 1.0 N B:CYS609 4.1 32.6 1.0 O B:HOH2021 4.2 25.7 1.0 N B:CYS622 4.3 28.2 1.0 O B:HOH2043 4.3 54.0 1.0 CA B:ASN607 4.3 35.4 1.0 CA B:CYS609 4.3 31.0 1.0 CA B:CYS622 4.4 29.2 1.0 N B:ASN607 4.4 35.8 1.0 N B:ASP608 4.5 35.2 1.0 C B:ASN607 4.7 34.9 1.0 CA B:CYS619 4.7 28.8 1.0 N B:ALA604 4.8 31.0 1.0 C B:CYS603 4.8 30.6 1.0 N B:GLY605 4.9 31.7 1.0

S.C.Roemer, D.C.Donham, L.Sherman, V.H.Pon, D.P.Edwards, M.E.A.Churchill. Structure of the Progesterone Receptor- Deoxyribonucleic Acid Complex: Novel Interactions Required For Binding to Half-Site Response Elements. Mol.Endocrinol. V. 20 3042 2006.
ISSN: ISSN 0888-8809
PubMed: 16931575
DOI: 10.1210/ME.2005-0511