Zinc in PDB 2c6f: Structure of Human Somatic Angiontensin-I Converting Enzyme N Domain

All present enzymatic activity of Structure of Human Somatic Angiontensin-I Converting Enzyme N Domain:
3.4.15.1;

The structure of Structure of Human Somatic Angiontensin-I Converting Enzyme N Domain, PDB code: 2c6f was solved by H.R.Corradi, S.L.U.Schwager, A.Nichinda, E.D.Sturrock, K.R.Acharya, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.91 / 3.01
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	101.120, 211.320, 171.270, 90.00, 90.00, 90.00
R / Rfree (%)	22.4 / 27.3

The structure of Structure of Human Somatic Angiontensin-I Converting Enzyme N Domain also contains other interesting chemical elements:

Chlorine

(Cl)

2 atoms

The binding sites of Zinc atom in the Structure of Human Somatic Angiontensin-I Converting Enzyme N Domain (pdb code 2c6f). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of Human Somatic Angiontensin-I Converting Enzyme N Domain, PDB code: 2c6f:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Structure of Human Somatic Angiontensin-I Converting Enzyme N Domain


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Human Somatic Angiontensin-I Converting Enzyme N Domain within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn701 b:31.6 occ:1.00 OE1 A:GLU389 2.0 28.7 1.0 NE2 A:HIS361 2.1 29.4 1.0 NE2 A:HIS365 2.3 34.6 1.0 O A:HOH2011 2.6 2.8 1.0 CE1 A:HIS361 2.8 29.7 1.0 CD A:GLU389 3.0 29.2 1.0 CD2 A:HIS361 3.2 30.3 1.0 CD2 A:HIS365 3.2 35.1 1.0 CE1 A:HIS365 3.3 34.5 1.0 OE2 A:GLU389 3.4 28.9 1.0 ND1 A:HIS361 4.0 30.4 1.0 OH A:TYR501 4.2 34.8 1.0 CE2 A:TYR501 4.2 32.8 1.0 CG A:HIS361 4.2 30.8 1.0 OE2 A:GLU362 4.3 33.7 1.0 CG A:GLU389 4.4 28.8 1.0 ND1 A:HIS365 4.4 34.1 1.0 CG A:HIS365 4.4 34.7 1.0 CA A:GLU389 4.7 28.2 1.0 CZ A:TYR501 4.7 34.6 1.0 CB A:GLU389 4.7 27.6 1.0 OE1 A:GLU362 4.8 35.7 1.0 CD A:GLU362 4.9 33.8 1.0

Zinc binding site 2 out of 2 in the Structure of Human Somatic Angiontensin-I Converting Enzyme N Domain


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of Human Somatic Angiontensin-I Converting Enzyme N Domain within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn701 b:29.0 occ:1.00 OE1 B:GLU389 1.8 33.5 1.0 NE2 B:HIS361 2.1 33.1 1.0 NE2 B:HIS365 2.2 37.0 1.0 CE1 B:HIS361 2.8 33.3 1.0 O B:HOH2013 2.9 8.1 1.0 CD B:GLU389 2.9 34.2 1.0 CD2 B:HIS365 3.1 36.7 1.0 CE1 B:HIS365 3.2 35.3 1.0 CD2 B:HIS361 3.3 33.7 1.0 OE2 B:GLU389 3.3 33.7 1.0 OH B:TYR501 3.8 38.7 1.0 ND1 B:HIS361 4.0 34.9 1.0 CE2 B:TYR501 4.0 36.4 1.0 CG B:GLU389 4.2 33.9 1.0 ND1 B:HIS365 4.3 34.8 1.0 CG B:HIS361 4.3 34.7 1.0 CG B:HIS365 4.3 35.4 1.0 CZ B:TYR501 4.4 38.1 1.0 CA B:GLU389 4.5 33.0 1.0 CB B:GLU389 4.5 33.7 1.0 OE1 B:GLU362 4.6 41.2 1.0 OE2 B:GLU362 4.9 42.5 1.0

H.R.Corradi, S.L.U.Schwager, A.T.Nchinda, E.D.Sturrock, K.R.Acharya. Crystal Structure of the N Domain of Human Somatic Angiotensin I-Converting Enzyme Provides A Structural Basis For Domain-Specific Inhibitor Design. J.Mol.Biol. V. 357 964 2006.
ISSN: ISSN 0022-2836
PubMed: 16476442
DOI: 10.1016/J.JMB.2006.01.048