Zinc in PDB 2bo9: Human Carboxypeptidase A4 in Complex with Human Latexin.

The structure of Human Carboxypeptidase A4 in Complex with Human Latexin., PDB code: 2bo9 was solved by I.Pallares, R.Bonet, R.Garcia-Castellanos, S.Ventura, F.X.Aviles, J.Vendrell, F.X.Gomis-Rueth, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 1.60
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	78.922, 96.651, 92.358, 90.00, 99.60, 90.00
R / Rfree (%)	14.9 / 17.6

The binding sites of Zinc atom in the Human Carboxypeptidase A4 in Complex with Human Latexin. (pdb code 2bo9). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Human Carboxypeptidase A4 in Complex with Human Latexin., PDB code: 2bo9:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Human Carboxypeptidase A4 in Complex with Human Latexin.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human Carboxypeptidase A4 in Complex with Human Latexin. within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn902 b:12.0 occ:1.00 ND1 A:HIS196 2.0 10.5 1.0 ND1 A:HIS69 2.0 10.2 1.0 O A:HOH1003 2.2 4.7 1.0 OE2 A:GLU72 2.3 12.1 1.0 OE1 A:GLU72 2.3 11.6 1.0 CD A:GLU72 2.6 10.9 1.0 CE1 A:HIS196 2.9 11.1 1.0 CE1 A:HIS69 3.0 11.5 1.0 CG A:HIS69 3.1 9.5 1.0 CG A:HIS196 3.1 9.4 1.0 CB A:HIS69 3.5 9.6 1.0 CB A:HIS196 3.5 10.7 1.0 NH2 A:ARG127 4.0 12.1 1.0 O A:HOH1202 4.0 7.4 1.0 CG A:GLU72 4.1 9.3 1.0 NE2 A:HIS196 4.1 11.6 1.0 NE2 A:HIS69 4.1 9.2 1.0 CD2 A:HIS69 4.2 11.1 1.0 CD2 A:HIS196 4.2 12.8 1.0 O A:SER197 4.2 11.1 1.0 N A:VAL903 4.2 15.5 1.0 CA A:HIS196 4.3 10.3 1.0 O A:HOH1069 4.4 6.7 1.0 O A:HOH1204 4.4 9.3 1.0 CA A:VAL903 4.5 12.5 1.0 C A:VAL903 4.5 10.2 1.0 OXT A:VAL903 4.5 8.7 1.0 N A:SER197 4.6 11.4 1.0 OE2 A:GLU270 4.6 32.4 1.0 CA A:HIS69 4.8 9.4 1.0 CZ A:ARG127 4.8 10.7 1.0 OE1 A:GLU270 4.9 26.0 1.0 N A:HIS69 4.9 9.9 1.0 CB A:GLU72 5.0 10.0 1.0 O A:VAL903 5.0 9.4 1.0

Zinc binding site 2 out of 2 in the Human Carboxypeptidase A4 in Complex with Human Latexin.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Human Carboxypeptidase A4 in Complex with Human Latexin. within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn403 b:12.7 occ:1.00 ND1 C:HIS69 2.0 11.2 1.0 ND1 C:HIS196 2.1 11.8 1.0 O C:HOH503 2.2 3.5 1.0 OE2 C:GLU72 2.3 12.2 1.0 OE1 C:GLU72 2.3 11.5 1.0 CD C:GLU72 2.6 11.0 1.0 CE1 C:HIS69 2.9 11.7 1.0 CE1 C:HIS196 3.0 11.1 1.0 CG C:HIS69 3.1 10.7 1.0 CG C:HIS196 3.1 10.8 1.0 CB C:HIS69 3.5 9.6 1.0 CB C:HIS196 3.6 10.8 1.0 O C:HOH722 4.0 8.9 1.0 NH2 C:ARG127 4.0 12.9 1.0 NE2 C:HIS69 4.1 10.0 1.0 NE2 C:HIS196 4.1 11.9 1.0 N C:VAL401 4.1 14.8 1.0 CG C:GLU72 4.1 10.5 1.0 CD2 C:HIS69 4.2 11.1 1.0 CD2 C:HIS196 4.2 13.4 1.0 O C:SER197 4.3 11.5 1.0 CA C:HIS196 4.3 11.4 1.0 O C:HOH578 4.4 6.8 1.0 OXT C:VAL401 4.5 7.8 1.0 C C:VAL401 4.5 10.0 1.0 CA C:VAL401 4.5 12.1 1.0 O C:HOH667 4.5 9.0 1.0 N C:SER197 4.6 11.4 1.0 OE2 C:GLU270 4.7 32.0 1.0 CZ C:ARG127 4.8 11.6 1.0 CA C:HIS69 4.8 10.1 1.0 OE1 C:GLU270 4.9 26.5 1.0 N C:HIS69 4.9 10.8 1.0 O C:VAL401 5.0 9.1 1.0 CG2 C:ILE68 5.0 13.5 1.0

I.Pallares, R.Bonet, R.Garcia-Castellanos, S.Ventura, F.X.Aviles, J.Vendrell, F.X.Gomis-Rueth. Structure of Human Carboxypeptidase A4 with Its Endogenous Protein Inhibitor, Latexin. Proc.Natl.Acad.Sci.Usa V. 102 3978 2005.
ISSN: ISSN 0027-8424
PubMed: 15738388
DOI: 10.1073/PNAS.0500678102