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Zinc in PDB 2bbf: Crystal Structure of Trna-Guanine Transglycosylase (Tgt) From Zymomonas Mobilis in Complex with 6-Amino-3,7-Dihydro-Imidazo[4,5- G]Quinazolin-8-One

Enzymatic activity of Crystal Structure of Trna-Guanine Transglycosylase (Tgt) From Zymomonas Mobilis in Complex with 6-Amino-3,7-Dihydro-Imidazo[4,5- G]Quinazolin-8-One

All present enzymatic activity of Crystal Structure of Trna-Guanine Transglycosylase (Tgt) From Zymomonas Mobilis in Complex with 6-Amino-3,7-Dihydro-Imidazo[4,5- G]Quinazolin-8-One:
2.4.2.29;

Protein crystallography data

The structure of Crystal Structure of Trna-Guanine Transglycosylase (Tgt) From Zymomonas Mobilis in Complex with 6-Amino-3,7-Dihydro-Imidazo[4,5- G]Quinazolin-8-One, PDB code: 2bbf was solved by B.Stengl, E.A.Meyer, A.Heine, R.Brenk, F.Diederich, G.Klebe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 32.80 / 1.70
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 91.200, 65.590, 69.810, 90.00, 96.07, 90.00
R / Rfree (%) 19.6 / 22

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Trna-Guanine Transglycosylase (Tgt) From Zymomonas Mobilis in Complex with 6-Amino-3,7-Dihydro-Imidazo[4,5- G]Quinazolin-8-One (pdb code 2bbf). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Trna-Guanine Transglycosylase (Tgt) From Zymomonas Mobilis in Complex with 6-Amino-3,7-Dihydro-Imidazo[4,5- G]Quinazolin-8-One, PDB code: 2bbf:

Zinc binding site 1 out of 1 in 2bbf

Go back to Zinc Binding Sites List in 2bbf
Zinc binding site 1 out of 1 in the Crystal Structure of Trna-Guanine Transglycosylase (Tgt) From Zymomonas Mobilis in Complex with 6-Amino-3,7-Dihydro-Imidazo[4,5- G]Quinazolin-8-One


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Trna-Guanine Transglycosylase (Tgt) From Zymomonas Mobilis in Complex with 6-Amino-3,7-Dihydro-Imidazo[4,5- G]Quinazolin-8-One within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn400

b:17.2
occ:1.00
 ND1 A:HIS349 2.1 12.6 1.0
SG A:CYS323 2.3 16.2 1.0
SG A:CYS318 2.3 16.8 1.0
SG A:CYS320 2.3 15.8 1.0
CE1 A:HIS349 2.9 13.2 1.0
CB A:CYS318 3.3 19.8 1.0
CG A:HIS349 3.3 13.2 1.0
CB A:CYS323 3.3 15.6 1.0
CB A:CYS320 3.3 16.4 1.0
CB A:HIS349 3.8 13.4 1.0
N A:CYS323 3.9 13.9 1.0
NE2 A:HIS349 4.1 12.8 1.0
N A:CYS320 4.1 20.5 1.0
CA A:HIS349 4.1 11.3 1.0
CA A:CYS323 4.2 15.9 1.0
CA A:CYS320 4.2 17.3 1.0
CD2 A:HIS349 4.3 13.5 1.0
O A:HIS349 4.5 12.2 1.0
CA A:CYS318 4.6 22.1 1.0
O A:CYS320 4.6 16.4 1.0
C A:CYS318 4.7 22.6 1.0
C A:CYS320 4.7 17.1 1.0
C A:HIS349 4.8 12.6 1.0
CB A:VAL322 4.8 14.0 1.0
O A:CYS318 4.8 21.8 1.0
C A:VAL322 4.9 15.8 1.0
CB A:LEU314 5.0 19.6 1.0

Reference:

B.Stengl, E.A.Meyer, A.Heine, R.Brenk, F.Diederich, G.Klebe. Crystal Structures of Trna-Guanine Transglycosylase (Tgt) in Complex with Novel and Potent Inhibitors Unravel Pronounced Induced-Fit Adaptations and Suggest Dimer Formation Upon Substrate Binding. J.Mol.Biol. V. 370 492 2007.
ISSN: ISSN 0022-2836
PubMed: 17524419
DOI: 10.1016/J.JMB.2007.04.008
Page generated: Wed Oct 16 21:58:10 2024

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