Zinc in PDB 1wxy: Crystal Structure of Adenosine Deaminase Ligated with A Potent Inhibitor

All present enzymatic activity of Crystal Structure of Adenosine Deaminase Ligated with A Potent Inhibitor:
3.5.4.4;

The structure of Crystal Structure of Adenosine Deaminase Ligated with A Potent Inhibitor, PDB code: 1wxy was solved by T.Kinoshita, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.15 / 2.50
Space group	P 43 21 2
Cell size a, b, c (Å), α, β, γ (°)	76.870, 76.870, 134.130, 90.00, 90.00, 90.00
R / Rfree (%)	n/a / n/a

The binding sites of Zinc atom in the Crystal Structure of Adenosine Deaminase Ligated with A Potent Inhibitor (pdb code 1wxy). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Adenosine Deaminase Ligated with A Potent Inhibitor, PDB code: 1wxy:

Zinc binding site 1 out of 1 in the Crystal Structure of Adenosine Deaminase Ligated with A Potent Inhibitor


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Adenosine Deaminase Ligated with A Potent Inhibitor within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn400 b:33.3 occ:1.00 O A:HOH593 1.9 23.3 1.0 NE2 A:HIS17 1.9 17.6 1.0 NE2 A:HIS15 2.0 17.0 1.0 NE2 A:HIS214 2.3 29.8 1.0 OD2 A:ASP295 2.6 28.8 1.0 CD2 A:HIS17 2.8 20.8 1.0 CE1 A:HIS15 2.9 19.1 1.0 CE1 A:HIS17 3.1 21.8 1.0 CD2 A:HIS15 3.1 23.1 1.0 CD2 A:HIS214 3.2 28.5 1.0 CE1 A:HIS214 3.2 27.9 1.0 CG A:ASP295 3.5 27.6 1.0 O A:HOH589 3.7 51.6 1.0 OD1 A:ASP295 4.0 26.0 1.0 CG A:HIS17 4.1 21.1 1.0 ND1 A:HIS15 4.1 16.1 1.0 NE2 A:HIS238 4.1 24.9 1.0 ND1 A:HIS17 4.2 18.3 1.0 CG A:HIS15 4.2 18.0 1.0 O A:HOH427 4.3 27.9 1.0 ND1 A:HIS214 4.3 28.4 1.0 CG A:HIS214 4.3 24.9 1.0 CB A:ASP295 4.5 25.8 1.0 O A:HOH516 4.5 56.2 1.0 NH1 A:ARG101 4.7 18.4 1.0 OD2 A:ASP296 4.8 32.2 1.0 CD2 A:HIS238 4.8 22.5 1.0 CD A:ARG101 4.9 8.8 1.0

T.Kinoshita, I.Nakanishi, T.Terasaka, M.Kuno, N.Seki, M.Warizaya, H.Matsumura, T.Inoue, K.Takano, H.Adachi, Y.Mori, T.Fujii. Structural Basis of Compound Recognition By Adenosine Deaminase Biochemistry V. 44 10562 2005.
ISSN: ISSN 0006-2960
PubMed: 16060665
DOI: 10.1021/BI050529E