Zinc in PDB 1uxl: I113T Mutant of Human SOD1
Enzymatic activity of I113T Mutant of Human SOD1
All present enzymatic activity of I113T Mutant of Human SOD1:
1.15.1.1;
Protein crystallography data
The structure of I113T Mutant of Human SOD1, PDB code: 1uxl
was solved by
M.A.Hough,
J.G.Grossmann,
S.V.Antonyuk,
R.W.Strange,
P.A.Doucette,
J.A.Rodriguez,
L.J.Whitson,
P.J.Hart,
L.J.Hayward,
J.S.Valentine,
S.S.Hasnain,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
|
Resolution Low / High (Å)
|
20.00 /
1.6
|
|
Space group
|
C 2 2 21
|
|
Cell size a, b, c (Å), α, β, γ (°)
|
166.042,
203.546,
144.021,
90.00,
90.00,
90.00
|
|
R / Rfree (%)
|
17 /
19.6
|
Other elements in 1uxl:
The structure of I113T Mutant of Human SOD1 also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the I113T Mutant of Human SOD1
(pdb code 1uxl). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 10 binding sites of Zinc where determined in the
I113T Mutant of Human SOD1, PDB code: 1uxl:
Jump to Zinc binding site number:
1;
2;
3;
4;
5;
6;
7;
8;
9;
10;
Zinc binding site 1 out
of 10 in 1uxl
Go back to
Zinc Binding Sites List in 1uxl
Zinc binding site 1 out
of 10 in the I113T Mutant of Human SOD1
 Mono view
 Stereo pair view
|
|
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of I113T Mutant of Human SOD1 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Zn155
b:14.4
occ:1.00
|
OD1
|
A:ASP83
|
2.0
|
13.3
|
1.0
|
|
ND1
|
A:HIS63
|
2.0
|
13.8
|
1.0
|
|
ND1
|
A:HIS71
|
2.0
|
11.5
|
1.0
|
|
ND1
|
A:HIS80
|
2.1
|
15.3
|
1.0
|
|
CG
|
A:ASP83
|
2.8
|
11.0
|
1.0
|
|
OD2
|
A:ASP83
|
2.8
|
12.8
|
1.0
|
|
CE1
|
A:HIS71
|
2.8
|
13.0
|
1.0
|
|
CE1
|
A:HIS63
|
2.9
|
15.3
|
1.0
|
|
CE1
|
A:HIS80
|
3.0
|
13.7
|
1.0
|
|
CG
|
A:HIS63
|
3.0
|
13.3
|
1.0
|
|
CG
|
A:HIS80
|
3.1
|
13.5
|
1.0
|
|
CG
|
A:HIS71
|
3.2
|
14.4
|
1.0
|
|
CB
|
A:HIS63
|
3.4
|
12.8
|
1.0
|
|
CB
|
A:HIS80
|
3.6
|
12.5
|
1.0
|
|
CB
|
A:HIS71
|
3.6
|
14.1
|
1.0
|
|
CA
|
A:HIS71
|
3.9
|
14.7
|
1.0
|
|
NE2
|
A:HIS71
|
4.0
|
12.5
|
1.0
|
|
NE2
|
A:HIS63
|
4.0
|
16.7
|
1.0
|
|
O
|
A:LYS136
|
4.1
|
23.7
|
1.0
|
|
NE2
|
A:HIS80
|
4.1
|
15.4
|
1.0
|
|
CD2
|
A:HIS63
|
4.1
|
15.9
|
1.0
|
|
CB
|
A:ASP83
|
4.2
|
11.4
|
1.0
|
|
CD2
|
A:HIS71
|
4.2
|
12.9
|
1.0
|
|
CD2
|
A:HIS80
|
4.2
|
14.6
|
1.0
|
|
N
|
A:GLY72
|
4.7
|
14.6
|
1.0
|
|
CA
|
A:ASP83
|
4.7
|
11.5
|
1.0
|
|
N
|
A:HIS80
|
4.7
|
12.2
|
1.0
|
|
CA
|
A:HIS80
|
4.8
|
12.0
|
1.0
|
|
C
|
A:HIS71
|
4.8
|
14.4
|
1.0
|
|
O
|
A:HOH2222
|
4.8
|
32.6
|
1.0
|
|
N
|
A:ASP83
|
4.9
|
11.2
|
1.0
|
|
CA
|
A:HIS63
|
5.0
|
12.0
|
1.0
|
|
N
|
A:HIS71
|
5.0
|
15.1
|
1.0
|
|
O
|
A:GLY72
|
5.0
|
14.3
|
1.0
|
|
Zinc binding site 2 out
of 10 in 1uxl
Go back to
Zinc Binding Sites List in 1uxl
Zinc binding site 2 out
of 10 in the I113T Mutant of Human SOD1
 Mono view
 Stereo pair view
|
|
A full contact list of Zinc with other atoms in the Zn binding
site number 2 of I113T Mutant of Human SOD1 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Zn155
b:18.7
occ:1.00
|
ND1
|
B:HIS80
|
1.7
|
23.8
|
1.0
|
|
OD1
|
B:ASP83
|
1.9
|
19.0
|
1.0
|
|
ND1
|
B:HIS71
|
2.1
|
17.6
|
1.0
|
|
ND1
|
B:HIS63
|
2.1
|
19.4
|
1.0
|
|
CE1
|
B:HIS80
|
2.5
|
25.2
|
1.0
|
|
CG
|
B:ASP83
|
2.7
|
18.0
|
1.0
|
|
OD2
|
B:ASP83
|
2.7
|
18.3
|
1.0
|
|
CG
|
B:HIS80
|
2.8
|
20.6
|
1.0
|
|
CE1
|
B:HIS71
|
2.9
|
19.6
|
1.0
|
|
CE1
|
B:HIS63
|
3.0
|
21.9
|
1.0
|
|
CG
|
B:HIS63
|
3.1
|
21.4
|
1.0
|
|
CG
|
B:HIS71
|
3.2
|
21.2
|
1.0
|
|
CB
|
B:HIS80
|
3.4
|
17.8
|
1.0
|
|
CB
|
B:HIS63
|
3.5
|
20.0
|
1.0
|
|
NE2
|
B:HIS80
|
3.7
|
22.9
|
1.0
|
|
CB
|
B:HIS71
|
3.7
|
20.3
|
1.0
|
|
CD2
|
B:HIS80
|
3.8
|
23.3
|
1.0
|
|
CA
|
B:HIS71
|
4.0
|
20.7
|
1.0
|
|
O
|
B:LYS136
|
4.0
|
28.8
|
1.0
|
|
NE2
|
B:HIS71
|
4.1
|
20.0
|
1.0
|
|
CB
|
B:ASP83
|
4.1
|
17.4
|
1.0
|
|
NE2
|
B:HIS63
|
4.1
|
21.3
|
1.0
|
|
CD2
|
B:HIS63
|
4.2
|
22.7
|
1.0
|
|
CD2
|
B:HIS71
|
4.3
|
20.2
|
1.0
|
|
CA
|
B:ASP83
|
4.6
|
16.9
|
1.0
|
|
N
|
B:HIS80
|
4.6
|
18.5
|
1.0
|
|
CA
|
B:HIS80
|
4.7
|
18.2
|
1.0
|
|
N
|
B:GLY72
|
4.7
|
20.2
|
1.0
|
|
CD2
|
B:HIS46
|
4.8
|
19.9
|
1.0
|
|
N
|
B:ASP83
|
4.9
|
16.2
|
1.0
|
|
C
|
B:HIS71
|
4.9
|
20.4
|
1.0
|
|
N
|
B:HIS71
|
4.9
|
21.4
|
1.0
|
|
NE2
|
B:HIS46
|
4.9
|
21.1
|
1.0
|
|
C
|
B:LYS136
|
5.0
|
29.0
|
1.0
|
|
Zinc binding site 3 out
of 10 in 1uxl
Go back to
Zinc Binding Sites List in 1uxl
Zinc binding site 3 out
of 10 in the I113T Mutant of Human SOD1
 Mono view
 Stereo pair view
|
|
A full contact list of Zinc with other atoms in the Zn binding
site number 3 of I113T Mutant of Human SOD1 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:Zn155
b:12.5
occ:1.00
|
OD1
|
C:ASP83
|
1.9
|
11.5
|
1.0
|
|
ND1
|
C:HIS80
|
2.0
|
12.9
|
1.0
|
|
ND1
|
C:HIS63
|
2.0
|
12.3
|
1.0
|
|
ND1
|
C:HIS71
|
2.1
|
9.8
|
1.0
|
|
CG
|
C:ASP83
|
2.7
|
11.6
|
1.0
|
|
OD2
|
C:ASP83
|
2.8
|
10.8
|
1.0
|
|
CE1
|
C:HIS80
|
2.9
|
12.7
|
1.0
|
|
CE1
|
C:HIS71
|
2.9
|
10.4
|
1.0
|
|
CE1
|
C:HIS63
|
2.9
|
13.8
|
1.0
|
|
CG
|
C:HIS63
|
3.0
|
13.0
|
1.0
|
|
CG
|
C:HIS80
|
3.1
|
11.3
|
1.0
|
|
CG
|
C:HIS71
|
3.2
|
11.4
|
1.0
|
|
CB
|
C:HIS63
|
3.4
|
12.1
|
1.0
|
|
CB
|
C:HIS80
|
3.5
|
10.9
|
1.0
|
|
CB
|
C:HIS71
|
3.6
|
11.8
|
1.0
|
|
O
|
C:LYS136
|
3.8
|
16.8
|
1.0
|
|
CA
|
C:HIS71
|
3.9
|
12.2
|
1.0
|
|
NE2
|
C:HIS80
|
4.0
|
12.3
|
1.0
|
|
NE2
|
C:HIS63
|
4.1
|
14.7
|
1.0
|
|
NE2
|
C:HIS71
|
4.1
|
10.5
|
1.0
|
|
CD2
|
C:HIS80
|
4.1
|
13.8
|
1.0
|
|
CD2
|
C:HIS63
|
4.1
|
14.8
|
1.0
|
|
CB
|
C:ASP83
|
4.2
|
11.7
|
1.0
|
|
CD2
|
C:HIS71
|
4.2
|
11.0
|
1.0
|
|
N
|
C:HIS80
|
4.7
|
10.5
|
1.0
|
|
CA
|
C:ASP83
|
4.7
|
11.2
|
1.0
|
|
N
|
C:GLY72
|
4.7
|
11.7
|
1.0
|
|
CA
|
C:HIS80
|
4.8
|
10.7
|
1.0
|
|
O
|
C:HOH2240
|
4.8
|
23.9
|
1.0
|
|
C
|
C:LYS136
|
4.8
|
17.1
|
1.0
|
|
C
|
C:HIS71
|
4.9
|
12.7
|
1.0
|
|
N
|
C:ASP83
|
4.9
|
11.1
|
1.0
|
|
N
|
C:HIS71
|
4.9
|
13.2
|
1.0
|
|
CA
|
C:HIS63
|
4.9
|
11.4
|
1.0
|
|
Zinc binding site 4 out
of 10 in 1uxl
Go back to
Zinc Binding Sites List in 1uxl
Zinc binding site 4 out
of 10 in the I113T Mutant of Human SOD1
 Mono view
 Stereo pair view
|
|
A full contact list of Zinc with other atoms in the Zn binding
site number 4 of I113T Mutant of Human SOD1 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:Zn155
b:21.9
occ:1.00
|
OD1
|
D:ASP83
|
1.6
|
8.3
|
1.0
|
|
ND1
|
D:HIS80
|
1.8
|
19.9
|
1.0
|
|
ND1
|
D:HIS63
|
2.0
|
17.7
|
1.0
|
|
ND1
|
D:HIS71
|
2.1
|
20.3
|
1.0
|
|
CG
|
D:ASP83
|
2.6
|
18.8
|
1.0
|
|
CE1
|
D:HIS80
|
2.7
|
23.6
|
1.0
|
|
OD2
|
D:ASP83
|
2.8
|
17.9
|
1.0
|
|
CG
|
D:HIS80
|
2.9
|
21.2
|
1.0
|
|
CE1
|
D:HIS71
|
2.9
|
19.4
|
1.0
|
|
CE1
|
D:HIS63
|
2.9
|
20.5
|
1.0
|
|
CG
|
D:HIS63
|
3.1
|
20.2
|
1.0
|
|
CG
|
D:HIS71
|
3.2
|
25.0
|
1.0
|
|
CB
|
D:HIS80
|
3.4
|
20.1
|
1.0
|
|
CB
|
D:HIS63
|
3.4
|
18.8
|
1.0
|
|
CB
|
D:HIS71
|
3.7
|
25.7
|
1.0
|
|
NE2
|
D:HIS80
|
3.8
|
23.7
|
1.0
|
|
CD2
|
D:HIS80
|
3.9
|
21.8
|
1.0
|
|
O
|
D:LYS136
|
3.9
|
30.6
|
1.0
|
|
CA
|
D:HIS71
|
4.0
|
26.4
|
1.0
|
|
CB
|
D:ASP83
|
4.0
|
17.8
|
1.0
|
|
NE2
|
D:HIS63
|
4.1
|
20.2
|
1.0
|
|
NE2
|
D:HIS71
|
4.1
|
21.8
|
1.0
|
|
CD2
|
D:HIS63
|
4.2
|
19.1
|
1.0
|
|
CD2
|
D:HIS71
|
4.3
|
22.1
|
1.0
|
|
CA
|
D:ASP83
|
4.6
|
17.9
|
1.0
|
|
CA
|
D:HIS80
|
4.6
|
21.3
|
1.0
|
|
N
|
D:HIS80
|
4.7
|
21.6
|
1.0
|
|
N
|
D:GLY72
|
4.7
|
24.9
|
1.0
|
|
O
|
D:HOH2161
|
4.8
|
49.4
|
1.0
|
|
N
|
D:ASP83
|
4.8
|
18.1
|
1.0
|
|
C
|
D:HIS71
|
4.9
|
25.9
|
1.0
|
|
N
|
D:HIS71
|
4.9
|
27.5
|
1.0
|
|
C
|
D:LYS136
|
4.9
|
30.3
|
1.0
|
|
CA
|
D:HIS63
|
5.0
|
18.4
|
1.0
|
|
Zinc binding site 5 out
of 10 in 1uxl
Go back to
Zinc Binding Sites List in 1uxl
Zinc binding site 5 out
of 10 in the I113T Mutant of Human SOD1
 Mono view
 Stereo pair view
|
|
A full contact list of Zinc with other atoms in the Zn binding
site number 5 of I113T Mutant of Human SOD1 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
E:Zn155
b:17.8
occ:1.00
|
OD1
|
E:ASP83
|
2.0
|
17.3
|
1.0
|
|
ND1
|
E:HIS80
|
2.0
|
17.7
|
1.0
|
|
ND1
|
E:HIS63
|
2.1
|
22.6
|
1.0
|
|
ND1
|
E:HIS71
|
2.1
|
17.8
|
1.0
|
|
CG
|
E:ASP83
|
2.7
|
18.8
|
1.0
|
|
OD2
|
E:ASP83
|
2.7
|
18.9
|
1.0
|
|
CE1
|
E:HIS80
|
2.8
|
19.1
|
1.0
|
|
CE1
|
E:HIS71
|
2.9
|
18.0
|
1.0
|
|
CE1
|
E:HIS63
|
3.0
|
23.2
|
1.0
|
|
CG
|
E:HIS80
|
3.1
|
18.2
|
1.0
|
|
CG
|
E:HIS63
|
3.1
|
22.3
|
1.0
|
|
CG
|
E:HIS71
|
3.2
|
19.2
|
1.0
|
|
CB
|
E:HIS63
|
3.4
|
20.2
|
1.0
|
|
CB
|
E:HIS80
|
3.5
|
18.6
|
1.0
|
|
CB
|
E:HIS71
|
3.7
|
19.5
|
1.0
|
|
O
|
E:LYS136
|
3.9
|
26.9
|
1.0
|
|
NE2
|
E:HIS80
|
4.0
|
19.4
|
1.0
|
|
CA
|
E:HIS71
|
4.0
|
19.4
|
1.0
|
|
NE2
|
E:HIS71
|
4.1
|
17.2
|
1.0
|
|
CD2
|
E:HIS80
|
4.1
|
18.7
|
1.0
|
|
NE2
|
E:HIS63
|
4.1
|
23.6
|
1.0
|
|
CB
|
E:ASP83
|
4.2
|
17.9
|
1.0
|
|
CD2
|
E:HIS63
|
4.2
|
23.9
|
1.0
|
|
CD2
|
E:HIS71
|
4.2
|
19.0
|
1.0
|
|
N
|
E:HIS80
|
4.7
|
18.9
|
1.0
|
|
CA
|
E:ASP83
|
4.7
|
17.6
|
1.0
|
|
N
|
E:GLY72
|
4.7
|
19.6
|
1.0
|
|
CA
|
E:HIS80
|
4.7
|
18.6
|
1.0
|
|
O
|
E:HOH2157
|
4.8
|
39.5
|
1.0
|
|
C
|
E:LYS136
|
4.9
|
26.3
|
1.0
|
|
C
|
E:HIS71
|
4.9
|
19.9
|
1.0
|
|
N
|
E:ASP83
|
4.9
|
17.1
|
1.0
|
|
N
|
E:HIS71
|
5.0
|
19.6
|
1.0
|
|
CA
|
E:HIS63
|
5.0
|
20.2
|
1.0
|
|
Zinc binding site 6 out
of 10 in 1uxl
Go back to
Zinc Binding Sites List in 1uxl
Zinc binding site 6 out
of 10 in the I113T Mutant of Human SOD1
 Mono view
 Stereo pair view
|
|
A full contact list of Zinc with other atoms in the Zn binding
site number 6 of I113T Mutant of Human SOD1 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
F:Zn155
b:12.0
occ:1.00
|
OD1
|
F:ASP83
|
1.9
|
10.4
|
1.0
|
|
ND1
|
F:HIS63
|
2.0
|
11.7
|
1.0
|
|
ND1
|
F:HIS80
|
2.0
|
13.2
|
1.0
|
|
ND1
|
F:HIS71
|
2.0
|
9.2
|
1.0
|
|
CG
|
F:ASP83
|
2.7
|
10.1
|
1.0
|
|
OD2
|
F:ASP83
|
2.8
|
10.2
|
1.0
|
|
CE1
|
F:HIS71
|
2.9
|
9.3
|
1.0
|
|
CE1
|
F:HIS80
|
2.9
|
11.0
|
1.0
|
|
CE1
|
F:HIS63
|
2.9
|
12.4
|
1.0
|
|
CG
|
F:HIS63
|
3.0
|
13.5
|
1.0
|
|
CG
|
F:HIS80
|
3.1
|
10.4
|
1.0
|
|
CG
|
F:HIS71
|
3.2
|
10.3
|
1.0
|
|
CB
|
F:HIS63
|
3.4
|
12.0
|
1.0
|
|
CB
|
F:HIS80
|
3.6
|
8.6
|
1.0
|
|
CB
|
F:HIS71
|
3.6
|
10.5
|
1.0
|
|
CA
|
F:HIS71
|
3.9
|
10.3
|
1.0
|
|
O
|
F:LYS136
|
3.9
|
17.0
|
1.0
|
|
NE2
|
F:HIS80
|
4.0
|
13.2
|
1.0
|
|
NE2
|
F:HIS71
|
4.1
|
11.1
|
1.0
|
|
NE2
|
F:HIS63
|
4.1
|
15.4
|
1.0
|
|
CD2
|
F:HIS63
|
4.1
|
15.9
|
1.0
|
|
CD2
|
F:HIS80
|
4.2
|
11.8
|
1.0
|
|
CB
|
F:ASP83
|
4.2
|
10.0
|
1.0
|
|
CD2
|
F:HIS71
|
4.2
|
10.5
|
1.0
|
|
CA
|
F:ASP83
|
4.7
|
9.8
|
1.0
|
|
N
|
F:HIS80
|
4.7
|
9.0
|
1.0
|
|
N
|
F:GLY72
|
4.7
|
9.8
|
1.0
|
|
CA
|
F:HIS80
|
4.8
|
9.3
|
1.0
|
|
O
|
F:HOH2280
|
4.8
|
24.6
|
1.0
|
|
N
|
F:ASP83
|
4.9
|
10.4
|
1.0
|
|
C
|
F:HIS71
|
4.9
|
10.3
|
1.0
|
|
C
|
F:LYS136
|
4.9
|
16.3
|
1.0
|
|
N
|
F:HIS71
|
4.9
|
11.3
|
1.0
|
|
CA
|
F:HIS63
|
5.0
|
11.5
|
1.0
|
|
Zinc binding site 7 out
of 10 in 1uxl
Go back to
Zinc Binding Sites List in 1uxl
Zinc binding site 7 out
of 10 in the I113T Mutant of Human SOD1
 Mono view
 Stereo pair view
|
|
A full contact list of Zinc with other atoms in the Zn binding
site number 7 of I113T Mutant of Human SOD1 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
G:Zn155
b:13.0
occ:1.00
|
ND1
|
G:HIS63
|
2.0
|
12.0
|
1.0
|
|
OD1
|
G:ASP83
|
2.0
|
11.8
|
1.0
|
|
ND1
|
G:HIS80
|
2.0
|
13.3
|
1.0
|
|
ND1
|
G:HIS71
|
2.1
|
12.6
|
1.0
|
|
CG
|
G:ASP83
|
2.8
|
11.8
|
1.0
|
|
CE1
|
G:HIS80
|
2.9
|
14.0
|
1.0
|
|
OD2
|
G:ASP83
|
2.9
|
11.9
|
1.0
|
|
CE1
|
G:HIS71
|
2.9
|
12.3
|
1.0
|
|
CE1
|
G:HIS63
|
2.9
|
13.2
|
1.0
|
|
CG
|
G:HIS63
|
3.0
|
13.5
|
1.0
|
|
CG
|
G:HIS80
|
3.1
|
11.2
|
1.0
|
|
CG
|
G:HIS71
|
3.2
|
12.3
|
1.0
|
|
CB
|
G:HIS63
|
3.4
|
12.0
|
1.0
|
|
CB
|
G:HIS80
|
3.6
|
11.3
|
1.0
|
|
CB
|
G:HIS71
|
3.6
|
12.1
|
1.0
|
|
O
|
G:LYS136
|
3.8
|
15.6
|
1.0
|
|
CA
|
G:HIS71
|
3.9
|
12.2
|
1.0
|
|
NE2
|
G:HIS80
|
4.0
|
13.3
|
1.0
|
|
NE2
|
G:HIS63
|
4.1
|
15.2
|
1.0
|
|
NE2
|
G:HIS71
|
4.1
|
11.7
|
1.0
|
|
CD2
|
G:HIS80
|
4.1
|
13.6
|
1.0
|
|
CD2
|
G:HIS63
|
4.1
|
15.5
|
1.0
|
|
CB
|
G:ASP83
|
4.2
|
11.6
|
1.0
|
|
CD2
|
G:HIS71
|
4.2
|
11.5
|
1.0
|
|
CA
|
G:ASP83
|
4.7
|
10.4
|
1.0
|
|
N
|
G:GLY72
|
4.7
|
11.5
|
1.0
|
|
N
|
G:HIS80
|
4.7
|
11.0
|
1.0
|
|
C
|
G:LYS136
|
4.7
|
14.7
|
1.0
|
|
CA
|
G:HIS80
|
4.8
|
11.5
|
1.0
|
|
O
|
G:HOH2249
|
4.8
|
23.2
|
1.0
|
|
C
|
G:HIS71
|
4.9
|
12.1
|
1.0
|
|
N
|
G:HIS71
|
4.9
|
13.7
|
1.0
|
|
CA
|
G:HIS63
|
4.9
|
12.4
|
1.0
|
|
N
|
G:ASP83
|
5.0
|
11.2
|
1.0
|
|
Zinc binding site 8 out
of 10 in 1uxl
Go back to
Zinc Binding Sites List in 1uxl
Zinc binding site 8 out
of 10 in the I113T Mutant of Human SOD1
 Mono view
 Stereo pair view
|
|
A full contact list of Zinc with other atoms in the Zn binding
site number 8 of I113T Mutant of Human SOD1 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
H:Zn155
b:12.5
occ:1.00
|
OD1
|
H:ASP83
|
2.0
|
10.2
|
1.0
|
|
ND1
|
H:HIS63
|
2.0
|
12.1
|
1.0
|
|
ND1
|
H:HIS80
|
2.0
|
13.7
|
1.0
|
|
ND1
|
H:HIS71
|
2.0
|
10.8
|
1.0
|
|
CG
|
H:ASP83
|
2.8
|
10.3
|
1.0
|
|
OD2
|
H:ASP83
|
2.8
|
10.9
|
1.0
|
|
CE1
|
H:HIS71
|
2.8
|
10.2
|
1.0
|
|
CE1
|
H:HIS80
|
2.9
|
13.9
|
1.0
|
|
CE1
|
H:HIS63
|
3.0
|
13.1
|
1.0
|
|
CG
|
H:HIS63
|
3.1
|
12.0
|
1.0
|
|
CG
|
H:HIS80
|
3.1
|
10.1
|
1.0
|
|
CG
|
H:HIS71
|
3.2
|
11.4
|
1.0
|
|
CB
|
H:HIS63
|
3.4
|
11.2
|
1.0
|
|
CB
|
H:HIS80
|
3.5
|
10.4
|
1.0
|
|
CB
|
H:HIS71
|
3.7
|
11.2
|
1.0
|
|
O
|
H:LYS136
|
3.8
|
18.5
|
1.0
|
|
CA
|
H:HIS71
|
3.9
|
11.8
|
1.0
|
|
NE2
|
H:HIS80
|
4.0
|
14.6
|
1.0
|
|
NE2
|
H:HIS71
|
4.0
|
9.7
|
1.0
|
|
NE2
|
H:HIS63
|
4.1
|
13.7
|
1.0
|
|
CD2
|
H:HIS80
|
4.1
|
13.2
|
1.0
|
|
CD2
|
H:HIS63
|
4.2
|
14.5
|
1.0
|
|
CB
|
H:ASP83
|
4.2
|
10.3
|
1.0
|
|
CD2
|
H:HIS71
|
4.2
|
11.5
|
1.0
|
|
N
|
H:GLY72
|
4.7
|
11.4
|
1.0
|
|
CA
|
H:ASP83
|
4.7
|
9.7
|
1.0
|
|
N
|
H:HIS80
|
4.7
|
10.6
|
1.0
|
|
CA
|
H:HIS80
|
4.8
|
10.6
|
1.0
|
|
C
|
H:LYS136
|
4.8
|
16.3
|
1.0
|
|
O
|
H:HOH2290
|
4.9
|
25.8
|
1.0
|
|
C
|
H:HIS71
|
4.9
|
11.8
|
1.0
|
|
N
|
H:ASP83
|
4.9
|
9.8
|
1.0
|
|
N
|
H:HIS71
|
5.0
|
13.0
|
1.0
|
|
CA
|
H:HIS63
|
5.0
|
10.8
|
1.0
|
|
Zinc binding site 9 out
of 10 in 1uxl
Go back to
Zinc Binding Sites List in 1uxl
Zinc binding site 9 out
of 10 in the I113T Mutant of Human SOD1
 Mono view
 Stereo pair view
|
|
A full contact list of Zinc with other atoms in the Zn binding
site number 9 of I113T Mutant of Human SOD1 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
I:Zn155
b:13.3
occ:1.00
|
OD1
|
I:ASP83
|
2.0
|
11.6
|
1.0
|
|
ND1
|
I:HIS80
|
2.0
|
14.8
|
1.0
|
|
ND1
|
I:HIS63
|
2.0
|
13.1
|
1.0
|
|
ND1
|
I:HIS71
|
2.0
|
10.7
|
1.0
|
|
CG
|
I:ASP83
|
2.8
|
12.0
|
1.0
|
|
OD2
|
I:ASP83
|
2.8
|
12.0
|
1.0
|
|
CE1
|
I:HIS80
|
2.9
|
14.6
|
1.0
|
|
CE1
|
I:HIS71
|
2.9
|
10.7
|
1.0
|
|
CE1
|
I:HIS63
|
3.0
|
15.1
|
1.0
|
|
CG
|
I:HIS80
|
3.1
|
12.5
|
1.0
|
|
CG
|
I:HIS63
|
3.1
|
16.1
|
1.0
|
|
CG
|
I:HIS71
|
3.2
|
11.9
|
1.0
|
|
CB
|
I:HIS63
|
3.4
|
14.3
|
1.0
|
|
CB
|
I:HIS80
|
3.5
|
13.7
|
1.0
|
|
CB
|
I:HIS71
|
3.6
|
12.7
|
1.0
|
|
O
|
I:LYS136
|
3.9
|
18.0
|
1.0
|
|
CA
|
I:HIS71
|
3.9
|
13.3
|
1.0
|
|
NE2
|
I:HIS80
|
4.0
|
16.0
|
1.0
|
|
NE2
|
I:HIS71
|
4.1
|
10.0
|
1.0
|
|
NE2
|
I:HIS63
|
4.1
|
16.0
|
1.0
|
|
CD2
|
I:HIS80
|
4.1
|
15.9
|
1.0
|
|
CD2
|
I:HIS63
|
4.2
|
15.8
|
1.0
|
|
CB
|
I:ASP83
|
4.2
|
12.1
|
1.0
|
|
CD2
|
I:HIS71
|
4.2
|
11.7
|
1.0
|
|
CA
|
I:ASP83
|
4.7
|
12.1
|
1.0
|
|
N
|
I:HIS80
|
4.7
|
13.3
|
1.0
|
|
N
|
I:GLY72
|
4.7
|
12.1
|
1.0
|
|
CA
|
I:HIS80
|
4.7
|
13.2
|
1.0
|
|
C
|
I:HIS71
|
4.9
|
13.5
|
1.0
|
|
N
|
I:ASP83
|
4.9
|
11.7
|
1.0
|
|
C
|
I:LYS136
|
4.9
|
17.2
|
1.0
|
|
N
|
I:HIS71
|
4.9
|
14.0
|
1.0
|
|
O
|
I:HOH2228
|
5.0
|
28.8
|
1.0
|
|
CA
|
I:HIS63
|
5.0
|
14.4
|
1.0
|
|
Zinc binding site 10 out
of 10 in 1uxl
Go back to
Zinc Binding Sites List in 1uxl
Zinc binding site 10 out
of 10 in the I113T Mutant of Human SOD1
 Mono view
 Stereo pair view
|
|
A full contact list of Zinc with other atoms in the Zn binding
site number 10 of I113T Mutant of Human SOD1 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
J:Zn155
b:13.2
occ:1.00
|
OD1
|
J:ASP83
|
1.9
|
12.2
|
1.0
|
|
ND1
|
J:HIS63
|
2.0
|
14.0
|
1.0
|
|
ND1
|
J:HIS80
|
2.0
|
11.6
|
1.0
|
|
ND1
|
J:HIS71
|
2.1
|
13.6
|
1.0
|
|
CG
|
J:ASP83
|
2.8
|
13.4
|
1.0
|
|
OD2
|
J:ASP83
|
2.9
|
12.6
|
1.0
|
|
CE1
|
J:HIS63
|
2.9
|
16.0
|
1.0
|
|
CE1
|
J:HIS71
|
2.9
|
12.7
|
1.0
|
|
CE1
|
J:HIS80
|
2.9
|
13.6
|
1.0
|
|
CG
|
J:HIS63
|
3.0
|
14.8
|
1.0
|
|
CG
|
J:HIS80
|
3.1
|
13.8
|
1.0
|
|
CG
|
J:HIS71
|
3.2
|
13.6
|
1.0
|
|
CB
|
J:HIS63
|
3.4
|
13.8
|
1.0
|
|
CB
|
J:HIS80
|
3.5
|
13.5
|
1.0
|
|
CB
|
J:HIS71
|
3.6
|
13.8
|
1.0
|
|
O
|
J:LYS136
|
3.9
|
15.6
|
1.0
|
|
CA
|
J:HIS71
|
4.0
|
14.4
|
1.0
|
|
NE2
|
J:HIS80
|
4.0
|
14.8
|
1.0
|
|
NE2
|
J:HIS63
|
4.0
|
16.0
|
1.0
|
|
NE2
|
J:HIS71
|
4.1
|
11.9
|
1.0
|
|
CD2
|
J:HIS63
|
4.1
|
18.1
|
1.0
|
|
CD2
|
J:HIS80
|
4.1
|
14.4
|
1.0
|
|
CB
|
J:ASP83
|
4.2
|
12.7
|
1.0
|
|
CD2
|
J:HIS71
|
4.2
|
11.9
|
1.0
|
|
CA
|
J:ASP83
|
4.7
|
12.6
|
1.0
|
|
N
|
J:HIS80
|
4.7
|
14.2
|
1.0
|
|
CA
|
J:HIS80
|
4.7
|
13.9
|
1.0
|
|
N
|
J:GLY72
|
4.7
|
14.0
|
1.0
|
|
C
|
J:LYS136
|
4.8
|
15.5
|
1.0
|
|
O
|
J:HOH2226
|
4.9
|
26.3
|
1.0
|
|
CD2
|
J:HIS46
|
4.9
|
13.0
|
1.0
|
|
C
|
J:HIS71
|
4.9
|
14.5
|
1.0
|
|
N
|
J:ASP83
|
4.9
|
12.4
|
1.0
|
|
CA
|
J:HIS63
|
5.0
|
13.8
|
1.0
|
|
N
|
J:HIS71
|
5.0
|
14.9
|
1.0
|
|
Reference:
M.A.Hough,
J.G.Grossmann,
S.V.Antonyuk,
R.W.Strange,
P.A.Doucette,
J.A.Rodriguez,
L.J.Whitson,
P.J.Hart,
L.J.Hayward,
J.S.Valentine,
S.S.Hasnain.
Dimer Destabilization in Superoxide Dismutase May Result in Disease-Causing Properties: Structures of Motor Neuron Disease Mutants Proc.Natl.Acad.Sci.Usa V. 101 5976 2004.
ISSN: ISSN 0027-8424
PubMed: 15056757
DOI: 10.1073/PNAS.0305143101
Page generated: Wed Oct 16 19:39:54 2024
|
