Atomistry » Zinc » PDB 1tnz-1u1j » 1tw6
Atomistry »
  Zinc »
    PDB 1tnz-1u1j »
      1tw6 »

Zinc in PDB 1tw6: Structure of An Ml-Iap/Xiap Chimera Bound to A 9MER Peptide Derived From Smac

Protein crystallography data

The structure of Structure of An Ml-Iap/Xiap Chimera Bound to A 9MER Peptide Derived From Smac, PDB code: 1tw6 was solved by M.C.Franklin, D.Vucic, H.J.A.Wallweber, K.Das, H.Shin, L.O.Elliott, S.Kadkhodayan, K.Deshayes, G.S.Salvesen, W.J.Fairbrother, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 47.75 / 1.71
Space group P 41 21 2
Cell size a, b, c (Å), α, β, γ (°) 87.856, 87.856, 74.634, 90.00, 90.00, 90.00
R / Rfree (%) 15.5 / 17.1

Zinc Binding Sites:

The binding sites of Zinc atom in the Structure of An Ml-Iap/Xiap Chimera Bound to A 9MER Peptide Derived From Smac (pdb code 1tw6). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of An Ml-Iap/Xiap Chimera Bound to A 9MER Peptide Derived From Smac, PDB code: 1tw6:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 1tw6

Go back to Zinc Binding Sites List in 1tw6
Zinc binding site 1 out of 2 in the Structure of An Ml-Iap/Xiap Chimera Bound to A 9MER Peptide Derived From Smac


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of An Ml-Iap/Xiap Chimera Bound to A 9MER Peptide Derived From Smac within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1001

b:8.9
occ:1.00
NE2 A:HIS144 2.1 6.9 1.0
SG A:CYS151 2.3 8.4 1.0
SG A:CYS127 2.3 8.3 1.0
SG A:CYS124 2.3 8.9 1.0
CE1 A:HIS144 2.9 9.2 1.0
CB A:CYS124 3.2 9.4 1.0
CB A:CYS151 3.2 8.0 1.0
CD2 A:HIS144 3.2 8.3 1.0
CB A:CYS127 3.3 8.5 1.0
N A:CYS127 3.7 6.4 1.0
CA A:CYS127 4.1 6.9 1.0
ND1 A:HIS144 4.1 8.4 1.0
CG A:HIS144 4.3 7.0 1.0
CA A:CYS151 4.5 7.4 1.0
CB A:PHE126 4.6 8.5 1.0
CA A:CYS124 4.6 8.2 1.0
C A:PHE126 4.8 7.3 1.0
CB A:PHE148 4.9 8.9 1.0
C A:CYS127 4.9 6.0 1.0
N A:PHE126 5.0 6.9 1.0

Zinc binding site 2 out of 2 in 1tw6

Go back to Zinc Binding Sites List in 1tw6
Zinc binding site 2 out of 2 in the Structure of An Ml-Iap/Xiap Chimera Bound to A 9MER Peptide Derived From Smac


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of An Ml-Iap/Xiap Chimera Bound to A 9MER Peptide Derived From Smac within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn1001

b:8.6
occ:1.00
NE2 B:HIS144 2.1 7.6 1.0
SG B:CYS151 2.3 7.8 1.0
SG B:CYS127 2.3 8.6 1.0
SG B:CYS124 2.3 7.7 1.0
CE1 B:HIS144 2.9 9.9 1.0
CB B:CYS124 3.1 8.6 1.0
CB B:CYS151 3.2 6.2 1.0
CD2 B:HIS144 3.2 8.4 1.0
CB B:CYS127 3.3 8.7 1.0
N B:CYS127 3.8 8.0 1.0
CA B:CYS127 4.1 9.0 1.0
ND1 B:HIS144 4.1 9.3 1.0
CG B:HIS144 4.3 8.8 1.0
CA B:CYS151 4.5 7.0 1.0
CA B:CYS124 4.6 7.0 1.0
CB B:PHE126 4.8 7.0 1.0
CB B:PHE148 4.8 8.6 1.0
C B:PHE126 4.9 6.5 1.0
C B:CYS127 4.9 7.8 1.0
CB B:PHE153 5.0 7.5 1.0

Reference:

D.Vucic, M.C.Franklin, H.J.A.Wallweber, K.Das, B.P.Eckelman, H.Shin, L.O.Elliott, S.Kadkhodayan, K.Deshayes, G.S.Salvesen, W.J.Fairbrother. Engineering Ml-Iap to Produce An Extraordinarily Potent Caspase 9 Inhibitor: Implications For Smac-Dependent Anti-Apoptotic Activity of Ml-Iap Biochem.J. V. 385 11 2005.
ISSN: ISSN 0264-6021
PubMed: 15485396
DOI: 10.1042/BJ20041108
Page generated: Wed Dec 16 03:05:41 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy