Zinc in PDB 1tqu: Golgi Alpha-Mannosidase II in Complex with the Salacinol Analog Ghavamiol

All present enzymatic activity of Golgi Alpha-Mannosidase II in Complex with the Salacinol Analog Ghavamiol:
3.2.1.114;

The structure of Golgi Alpha-Mannosidase II in Complex with the Salacinol Analog Ghavamiol, PDB code: 1tqu was solved by D.A.Kuntz, A.Ghavami, B.D.Johnston, B.M.Pinto, D.R.Rose, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.46 / 2.03
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	68.298, 108.957, 137.723, 90.00, 90.00, 90.00
R / Rfree (%)	13.2 / 18.2

The binding sites of Zinc atom in the Golgi Alpha-Mannosidase II in Complex with the Salacinol Analog Ghavamiol (pdb code 1tqu). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Golgi Alpha-Mannosidase II in Complex with the Salacinol Analog Ghavamiol, PDB code: 1tqu:

Zinc binding site 1 out of 1 in the Golgi Alpha-Mannosidase II in Complex with the Salacinol Analog Ghavamiol


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Golgi Alpha-Mannosidase II in Complex with the Salacinol Analog Ghavamiol within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1400 b:11.7 occ:1.00 NE2 A:HIS90 2.1 7.4 1.0 OD1 A:ASP92 2.1 12.8 1.0 NE2 A:HIS471 2.1 8.7 1.0 O2 A:GHA1300 2.1 14.1 1.0 OD1 A:ASP204 2.2 7.7 1.0 CG A:ASP92 2.9 10.1 1.0 OD2 A:ASP92 3.0 7.5 1.0 CD2 A:HIS90 3.0 7.7 1.0 CD2 A:HIS471 3.0 7.5 1.0 CE1 A:HIS90 3.0 8.9 1.0 CG A:ASP204 3.1 10.3 1.0 CE1 A:HIS471 3.1 9.6 1.0 C2 A:GHA1300 3.1 15.2 1.0 C3 A:GHA1300 3.4 17.6 1.0 CB A:ASP204 3.4 5.8 1.0 OD2 A:ASP472 4.0 7.1 1.0 C1 A:GHA1300 4.1 15.2 1.0 N4 A:GHA1300 4.1 15.6 1.0 ND1 A:HIS90 4.1 8.1 1.0 CG A:HIS90 4.2 6.6 1.0 CG A:HIS471 4.2 7.9 1.0 ND1 A:HIS471 4.2 8.3 1.0 O A:HOH2449 4.2 8.9 1.0 CE1 A:HIS470 4.2 9.2 1.0 OD2 A:ASP204 4.2 9.8 1.0 CB A:ASP92 4.2 5.5 1.0 C5 A:GHA1300 4.8 15.7 1.0 OH A:TYR269 4.8 11.2 1.0 CA A:ASP204 4.8 7.7 1.0 CA A:ASP92 4.9 8.7 1.0 NE2 A:HIS470 4.9 8.0 1.0 CG A:ASP472 5.0 7.9 1.0

D.A.Kuntz, A.Ghavami, B.D.Johnston, B.M.Pinto, D.R.Rose. Crystallographic Analysis of the Interactions of Drosophila Melanogaster Golgi Alpha-Mannosidase II with the Naturally Occurring Glycomimetic Salacinol and Its Analogues Tetrahedron Asymmetry V. 16 25 2005.
ISSN: ISSN 0957-4166