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Zinc in PDB 1tqs: Golgi Alpha-Mannosidase II in Complex with Salacinol

Enzymatic activity of Golgi Alpha-Mannosidase II in Complex with Salacinol

All present enzymatic activity of Golgi Alpha-Mannosidase II in Complex with Salacinol:
3.2.1.114;

Protein crystallography data

The structure of Golgi Alpha-Mannosidase II in Complex with Salacinol, PDB code: 1tqs was solved by D.A.Kuntz, A.Ghavami, B.D.Johnston, B.M.Pinto, D.R.Rose, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.33 / 1.30
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 68.824, 109.631, 138.852, 90.00, 90.00, 90.00
R / Rfree (%) 16.3 / 18.2

Zinc Binding Sites:

The binding sites of Zinc atom in the Golgi Alpha-Mannosidase II in Complex with Salacinol (pdb code 1tqs). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Golgi Alpha-Mannosidase II in Complex with Salacinol, PDB code: 1tqs:

Zinc binding site 1 out of 1 in 1tqs

Go back to Zinc Binding Sites List in 1tqs
Zinc binding site 1 out of 1 in the Golgi Alpha-Mannosidase II in Complex with Salacinol


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Golgi Alpha-Mannosidase II in Complex with Salacinol within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1401

b:8.0
occ:1.00
NE2 A:HIS471 2.0 5.5 1.0
OD1 A:ASP204 2.1 8.4 1.0
OD1 A:ASP92 2.1 9.3 1.0
NE2 A:HIS90 2.1 7.4 1.0
O2 A:SSO1201 2.1 10.4 1.0
CG A:ASP92 2.9 9.2 1.0
CD2 A:HIS471 3.0 5.6 1.0
CE1 A:HIS471 3.0 6.6 1.0
CE1 A:HIS90 3.0 6.5 1.0
OD2 A:ASP92 3.1 11.9 1.0
CG A:ASP204 3.1 7.2 1.0
CD2 A:HIS90 3.1 7.1 1.0
C2 A:SSO1201 3.3 13.5 1.0
C3 A:SSO1201 3.4 15.6 1.0
CB A:ASP204 3.5 7.4 1.0
OD2 A:ASP472 4.0 7.8 1.0
C1 A:SSO1201 4.1 13.0 1.0
ND1 A:HIS471 4.2 6.3 1.0
CG A:HIS471 4.2 5.3 1.0
ND1 A:HIS90 4.2 7.2 1.0
OD2 A:ASP204 4.2 9.2 1.0
CG A:HIS90 4.2 6.3 1.0
CB A:ASP92 4.3 7.3 1.0
CE1 A:HIS470 4.4 7.1 1.0
O A:HOH1990 4.4 9.4 1.0
S4 A:SSO1201 4.5 16.7 1.0
CA A:ASP92 4.9 6.7 1.0
OH A:TYR269 4.9 11.9 1.0
CA A:ASP204 5.0 7.2 1.0

Reference:

D.A.Kuntz, A.Ghavami, B.D.Johnston, B.M.Pinto, D.R.Rose. Crystallographic Analysis of the Interactions of Drosophila Melanogaster Golgi Alpha-Mannosidase II with the Naturally Occurring Glycomimetic Salacinol and Its Analogues Tetrahedron Asymmetry V. 16 25 2005.
ISSN: ISSN 0957-4166
Page generated: Wed Oct 16 19:16:03 2024

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