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Atomistry » Zinc » PDB 1tbn-1tny » 1tco » |
Zinc in PDB 1tco: Ternary Complex of A Calcineurin A Fragment, Calcineurin B, FKBP12 and the Immunosuppressant Drug FK506 (Tacrolimus)Enzymatic activity of Ternary Complex of A Calcineurin A Fragment, Calcineurin B, FKBP12 and the Immunosuppressant Drug FK506 (Tacrolimus)
All present enzymatic activity of Ternary Complex of A Calcineurin A Fragment, Calcineurin B, FKBP12 and the Immunosuppressant Drug FK506 (Tacrolimus):
3.1.3.16; 5.2.1.8; Protein crystallography data
The structure of Ternary Complex of A Calcineurin A Fragment, Calcineurin B, FKBP12 and the Immunosuppressant Drug FK506 (Tacrolimus), PDB code: 1tco
was solved by
J.P.Griffith,
J.L.Kim,
E.E.Kim,
M.D.Sintchak,
J.A.Thomson,
M.J.Fitzgibbon,
M.A.Fleming,
P.R.Caron,
K.Hsiao,
M.A.Navia,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 1tco:
The structure of Ternary Complex of A Calcineurin A Fragment, Calcineurin B, FKBP12 and the Immunosuppressant Drug FK506 (Tacrolimus) also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Ternary Complex of A Calcineurin A Fragment, Calcineurin B, FKBP12 and the Immunosuppressant Drug FK506 (Tacrolimus)
(pdb code 1tco). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Ternary Complex of A Calcineurin A Fragment, Calcineurin B, FKBP12 and the Immunosuppressant Drug FK506 (Tacrolimus), PDB code: 1tco: Zinc binding site 1 out of 1 in 1tcoGo back to Zinc Binding Sites List in 1tco
Zinc binding site 1 out
of 1 in the Ternary Complex of A Calcineurin A Fragment, Calcineurin B, FKBP12 and the Immunosuppressant Drug FK506 (Tacrolimus)
Mono view Stereo pair view
Reference:
J.P.Griffith,
J.L.Kim,
E.E.Kim,
M.D.Sintchak,
J.A.Thomson,
M.J.Fitzgibbon,
M.A.Fleming,
P.R.Caron,
K.Hsiao,
M.A.Navia.
X-Ray Structure of Calcineurin Inhibited By the Immunophilin-Immunosuppressant FKBP12-FK506 Complex. Cell(Cambridge,Mass.) V. 82 507 1995.
Page generated: Wed Dec 16 03:04:30 2020
ISSN: ISSN 0092-8674 PubMed: 7543369 DOI: 10.1016/0092-8674(95)90439-5 |
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