Zinc in PDB 1sr9: Crystal Structure of Leua From Mycobacterium Tuberculosis

All present enzymatic activity of Crystal Structure of Leua From Mycobacterium Tuberculosis:
2.3.3.13;

The structure of Crystal Structure of Leua From Mycobacterium Tuberculosis, PDB code: 1sr9 was solved by N.Koon, C.J.Squire, E.N.Baker, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.00 / 2.00
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	54.250, 154.730, 68.820, 90.00, 98.05, 90.00
R / Rfree (%)	16.9 / 19.7

The structure of Crystal Structure of Leua From Mycobacterium Tuberculosis also contains other interesting chemical elements:

Chlorine

(Cl)

1 atom

The binding sites of Zinc atom in the Crystal Structure of Leua From Mycobacterium Tuberculosis (pdb code 1sr9). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Leua From Mycobacterium Tuberculosis, PDB code: 1sr9:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of Leua From Mycobacterium Tuberculosis


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Leua From Mycobacterium Tuberculosis within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn704 b:39.8 occ:1.00 O2 A:KIV701 2.1 38.4 1.0 NE2 A:HIS285 2.1 29.5 1.0 NE2 A:HIS287 2.1 28.7 1.0 OD2 A:ASP81 2.2 33.8 1.0 O3 A:KIV701 2.4 33.2 1.0 O A:HOH1108 2.5 37.1 1.0 C1 A:KIV701 2.8 36.1 1.0 C2 A:KIV701 3.0 38.1 1.0 CD2 A:HIS285 3.1 28.5 1.0 CE1 A:HIS287 3.1 33.4 1.0 CE1 A:HIS285 3.1 26.7 1.0 CD2 A:HIS287 3.2 30.8 1.0 CG A:ASP81 3.2 34.7 1.0 OD1 A:ASP81 3.5 35.5 1.0 OD1 A:ASN321 3.8 36.4 1.0 O1 A:KIV701 4.1 37.4 1.0 ND1 A:HIS287 4.2 33.5 1.0 CG A:HIS285 4.2 28.5 1.0 O A:HOH993 4.2 39.5 1.0 ND1 A:HIS285 4.2 28.5 1.0 O A:HOH1019 4.2 38.7 1.0 NH2 A:ARG80 4.3 40.5 1.0 CG A:HIS287 4.3 29.4 1.0 C3 A:KIV701 4.4 36.1 1.0 CB A:ASP81 4.6 34.5 1.0 CG A:ASN321 4.6 29.1 1.0 NH1 A:ARG80 4.7 38.6 1.0 C5 A:KIV701 4.8 37.1 1.0 ND2 A:ASN321 4.9 29.7 1.0 CZ A:ARG80 4.9 38.7 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of Leua From Mycobacterium Tuberculosis


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Leua From Mycobacterium Tuberculosis within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn703 b:36.0 occ:1.00 OD2 B:ASP81 2.0 30.2 1.0 O2 B:KIV702 2.1 31.0 1.0 NE2 B:HIS287 2.2 26.9 1.0 NE2 B:HIS285 2.2 27.5 1.0 O3 B:KIV702 2.3 37.9 1.0 O B:HOH1257 2.4 35.3 1.0 C1 B:KIV702 2.9 33.0 1.0 C2 B:KIV702 2.9 35.6 1.0 CE1 B:HIS287 3.1 29.9 1.0 CD2 B:HIS285 3.1 27.7 1.0 CG B:ASP81 3.1 34.3 1.0 CD2 B:HIS287 3.2 26.7 1.0 CE1 B:HIS285 3.2 26.7 1.0 OD1 B:ASP81 3.6 36.0 1.0 OD1 B:ASN321 3.7 32.7 1.0 O1 B:KIV702 4.1 29.7 1.0 O B:HOH1029 4.1 37.9 1.0 ND1 B:HIS287 4.2 29.2 1.0 NH2 B:ARG80 4.2 31.7 1.0 CG B:HIS285 4.3 27.1 1.0 O B:HOH1184 4.3 39.1 1.0 ND1 B:HIS285 4.3 26.8 1.0 CG B:HIS287 4.3 26.1 1.0 C3 B:KIV702 4.3 37.6 1.0 CB B:ASP81 4.4 32.7 1.0 C5 B:KIV702 4.6 40.3 1.0 CG B:ASN321 4.6 29.5 1.0 NH1 B:ARG80 4.7 32.4 1.0 ND2 B:ASN321 4.8 26.1 1.0 CZ B:ARG80 4.9 31.6 1.0

N.Koon, C.J.Squire, E.N.Baker. Crystal Structure of Leua From Mycobacterium Tuberculosis, A Key Enzyme in Leucine Biosynthesis Proc.Natl.Acad.Sci.Usa V. 101 8295 2004.
ISSN: ISSN 0027-8424
PubMed: 15159544
DOI: 10.1073/PNAS.0400820101