Zinc in PDB 1rwe: Enhancing the Activity of Insulin at Receptor Edge: Crystal Structure and Photo-Cross-Linking of A8 Analogues

The structure of Enhancing the Activity of Insulin at Receptor Edge: Crystal Structure and Photo-Cross-Linking of A8 Analogues, PDB code: 1rwe was solved by Z.Wan, B.Xu, Y.C.Chu, B.Li, S.H.Nakagawa, Y.Qu, S.Q.Hu, P.G.Katsoyannis, M.A.Weiss, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.18 / 1.80
Space group	H 3
Cell size a, b, c (Å), α, β, γ (°)	79.341, 79.341, 34.708, 90.00, 90.00, 120.00
R / Rfree (%)	18.9 / 24.5

The structure of Enhancing the Activity of Insulin at Receptor Edge: Crystal Structure and Photo-Cross-Linking of A8 Analogues also contains other interesting chemical elements:

Chlorine

(Cl)

2 atoms

The binding sites of Zinc atom in the Enhancing the Activity of Insulin at Receptor Edge: Crystal Structure and Photo-Cross-Linking of A8 Analogues (pdb code 1rwe). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Enhancing the Activity of Insulin at Receptor Edge: Crystal Structure and Photo-Cross-Linking of A8 Analogues, PDB code: 1rwe:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Enhancing the Activity of Insulin at Receptor Edge: Crystal Structure and Photo-Cross-Linking of A8 Analogues


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Enhancing the Activity of Insulin at Receptor Edge: Crystal Structure and Photo-Cross-Linking of A8 Analogues within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn201 b:13.9 occ:0.33 NE2 B:HIS10 2.0 14.9 1.0 CL B:CL202 2.2 43.1 0.3 O B:HOH203 2.4 32.9 1.0 CE1 B:HIS10 2.8 16.3 1.0 CD2 B:HIS10 3.2 13.5 1.0 ND1 B:HIS10 4.0 16.0 1.0 O B:HOH238 4.1 45.4 1.0 CG B:HIS10 4.2 15.3 1.0

Zinc binding site 2 out of 2 in the Enhancing the Activity of Insulin at Receptor Edge: Crystal Structure and Photo-Cross-Linking of A8 Analogues


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Enhancing the Activity of Insulin at Receptor Edge: Crystal Structure and Photo-Cross-Linking of A8 Analogues within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn301 b:12.8 occ:0.33 NE2 D:HIS10 2.1 3.4 1.0 CL D:CL302 2.3 11.0 0.3 CE1 D:HIS10 3.0 2.9 1.0 CD2 D:HIS10 3.1 5.4 1.0 ND1 D:HIS10 4.1 6.0 1.0 CG D:HIS10 4.2 5.2 1.0 O D:LEU6 4.7 14.4 1.0 CB D:LEU6 4.8 14.7 1.0

Z.Wan, B.Xu, K.Huang, Y.C.Chu, B.Li, S.H.Nakagawa, Y.Qu, S.Q.Hu, P.G.Katsoyannis, M.A.Weiss. Enhancing the Activity of Insulin at the Receptor Interface: Crystal Structure and Photo-Cross-Linking of A8 Analogues. Biochemistry V. 43 16119 2004.
ISSN: ISSN 0006-2960
PubMed: 15610006
DOI: 10.1021/BI048223F