Zinc in PDB 1r54: Crystal Structure of the Catalytic Domain of Human ADAM33

The structure of Crystal Structure of the Catalytic Domain of Human ADAM33, PDB code: 1r54 was solved by P.Orth, P.Reicher, W.Wang, W.W.Prosise, T.Yarosh-Tomaine, G.Hammond, L.Xiao, U.A.Mirza, J.Zou, C.Strickland, S.S.Taremi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 1.85
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	56.476, 65.461, 99.863, 90.00, 90.00, 90.00
R / Rfree (%)	20.8 / 23.3

The structure of Crystal Structure of the Catalytic Domain of Human ADAM33 also contains other interesting chemical elements:

Chlorine	(Cl)	2 atoms
Calcium	(Ca)	1 atom

The binding sites of Zinc atom in the Crystal Structure of the Catalytic Domain of Human ADAM33 (pdb code 1r54). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of the Catalytic Domain of Human ADAM33, PDB code: 1r54:

Zinc binding site 1 out of 1 in the Crystal Structure of the Catalytic Domain of Human ADAM33


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the Catalytic Domain of Human ADAM33 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn201 b:26.9 occ:1.00 NE2 A:HIS355 2.0 21.6 1.0 NE2 A:HIS349 2.1 19.1 1.0 NE2 A:HIS345 2.2 20.1 1.0 O A:HOH23 2.5 26.4 1.0 CE1 A:HIS355 3.0 22.4 1.0 CD2 A:HIS355 3.0 21.2 1.0 CD2 A:HIS349 3.0 19.1 1.0 CE1 A:HIS349 3.1 21.0 1.0 CD2 A:HIS345 3.1 19.5 1.0 CE1 A:HIS345 3.2 20.3 1.0 ND1 A:HIS355 4.1 20.6 1.0 CG A:HIS355 4.1 21.4 1.0 ND1 A:HIS349 4.2 20.3 1.0 CG A:HIS349 4.2 20.1 1.0 CG A:HIS345 4.3 18.4 1.0 ND1 A:HIS345 4.3 18.4 1.0 O A:HOH65 4.3 30.2 1.0 OE2 A:GLU346 4.4 25.0 1.0 O A:HOH79 4.5 39.8 1.0 CE A:MET373 4.9 17.6 1.0 O A:HOH41 5.0 32.3 1.0

P.Orth, P.Reichert, W.Wang, W.W.Prosise, T.Yarosh-Tomaine, G.Hammond, L.Xiao, U.A.Mirza, J.Zou, C.Strickland, S.S.Taremi, H.V.Le, V.Madison. Crystal Structre of the Catalytic Domain of Human ADAM33 J.Mol.Biol. V. 335 129 2004.
ISSN: ISSN 0022-2836
PubMed: 14659745
DOI: 10.1016/J.JMB.2003.10.037