Atomistry » Zinc » PDB 1qm6-1r1v » 1qw4
Atomistry »
  Zinc »
    PDB 1qm6-1r1v »
      1qw4 »

Zinc in PDB 1qw4: Crystal Structure of Murine Inducible Nitric Oxide Synthase Oxygenase Domain in Complex with N-Omega-Propyl-L-Arginine.

Enzymatic activity of Crystal Structure of Murine Inducible Nitric Oxide Synthase Oxygenase Domain in Complex with N-Omega-Propyl-L-Arginine.

All present enzymatic activity of Crystal Structure of Murine Inducible Nitric Oxide Synthase Oxygenase Domain in Complex with N-Omega-Propyl-L-Arginine.:
1.14.13.39;

Protein crystallography data

The structure of Crystal Structure of Murine Inducible Nitric Oxide Synthase Oxygenase Domain in Complex with N-Omega-Propyl-L-Arginine., PDB code: 1qw4 was solved by R.Fedorov, E.Hartmann, D.K.Ghosh, I.Schlichting, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 8.00 / 2.40
Space group P 61 2 2
Cell size a, b, c (Å), α, β, γ (°) 214.603, 214.603, 117.464, 90.00, 90.00, 120.00
R / Rfree (%) 21.3 / 25.1

Other elements in 1qw4:

The structure of Crystal Structure of Murine Inducible Nitric Oxide Synthase Oxygenase Domain in Complex with N-Omega-Propyl-L-Arginine. also contains other interesting chemical elements:

Iron (Fe) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Murine Inducible Nitric Oxide Synthase Oxygenase Domain in Complex with N-Omega-Propyl-L-Arginine. (pdb code 1qw4). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Murine Inducible Nitric Oxide Synthase Oxygenase Domain in Complex with N-Omega-Propyl-L-Arginine., PDB code: 1qw4:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 1qw4

Go back to Zinc Binding Sites List in 1qw4
Zinc binding site 1 out of 2 in the Crystal Structure of Murine Inducible Nitric Oxide Synthase Oxygenase Domain in Complex with N-Omega-Propyl-L-Arginine.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Murine Inducible Nitric Oxide Synthase Oxygenase Domain in Complex with N-Omega-Propyl-L-Arginine. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn950

b:63.2
occ:0.50
 SG A:CYS104 2.0 61.1 1.0
SG A:CYS109 2.5 79.7 1.0
CB A:CYS104 3.1 80.1 1.0
CB A:CYS109 3.7 47.0 1.0
CA A:CYS109 4.0 56.4 1.0
N A:GLY111 4.4 44.1 1.0
N A:LEU110 4.5 57.9 1.0
CA A:CYS104 4.5 81.0 1.0
C A:CYS109 4.6 56.5 1.0
CA A:GLY111 4.7 42.5 1.0
N A:CYS104 4.9 75.1 1.0

Zinc binding site 2 out of 2 in 1qw4

Go back to Zinc Binding Sites List in 1qw4
Zinc binding site 2 out of 2 in the Crystal Structure of Murine Inducible Nitric Oxide Synthase Oxygenase Domain in Complex with N-Omega-Propyl-L-Arginine.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Murine Inducible Nitric Oxide Synthase Oxygenase Domain in Complex with N-Omega-Propyl-L-Arginine. within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn950

b:53.7
occ:0.50
 SG B:CYS104 2.1 48.5 1.0
SG B:CYS109 2.5 71.5 1.0
CB B:CYS104 3.2 66.6 1.0
CB B:CYS109 3.5 63.0 1.0
CA B:CYS109 3.9 63.1 1.0
N B:LEU110 4.5 52.8 1.0
C B:CYS109 4.5 60.5 1.0
CA B:CYS104 4.5 69.6 1.0
N B:GLY111 4.6 41.5 1.0
CA B:GLY111 4.8 42.8 1.0

Reference:

R.Fedorov, E.Hartmann, D.K.Ghosh, I.Schlichting. Structural Basis For the Specificity of the Nitric-Oxide Synthase Inhibitors W1400 and Nomega-Propyl-L-Arg For the Inducible and Neuronal Isoforms. J.Biol.Chem. V. 278 45818 2003.
ISSN: ISSN 0021-9258
PubMed: 12954642
DOI: 10.1074/JBC.M306030200
Page generated: Wed Oct 16 18:16:51 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy