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Zinc in PDB 1qiy: Human Insulin Hexamers with Chain B His Mutated to Tyr Complexed with Phenol

Protein crystallography data

The structure of Human Insulin Hexamers with Chain B His Mutated to Tyr Complexed with Phenol, PDB code: 1qiy was solved by L.Tang, J.L.Whittingham, C.S.Verma, L.S.D.Caves, G.G.Dodson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 36.80 / 2.30
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 61.100, 62.080, 48.350, 90.00, 109.87, 90.00
R / Rfree (%) 18.6 / n/a

Other elements in 1qiy:

The structure of Human Insulin Hexamers with Chain B His Mutated to Tyr Complexed with Phenol also contains other interesting chemical elements:

Chlorine (Cl) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Human Insulin Hexamers with Chain B His Mutated to Tyr Complexed with Phenol (pdb code 1qiy). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Human Insulin Hexamers with Chain B His Mutated to Tyr Complexed with Phenol, PDB code: 1qiy:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 1qiy

Go back to Zinc Binding Sites List in 1qiy
Zinc binding site 1 out of 2 in the Human Insulin Hexamers with Chain B His Mutated to Tyr Complexed with Phenol


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human Insulin Hexamers with Chain B His Mutated to Tyr Complexed with Phenol within 5.0Å range:
probe atom residue distance (Å) B Occ
J:Zn1001

b:19.0
occ:1.00
NE2 J:HIS10 2.1 23.2 1.0
NE2 B:HIS10 2.1 12.5 1.0
NE2 F:HIS10 2.1 20.1 1.0
CL J:CL1002 2.2 17.3 1.0
CE1 J:HIS10 3.0 11.9 1.0
CE1 B:HIS10 3.0 16.9 1.0
CE1 F:HIS10 3.1 14.3 1.0
CD2 J:HIS10 3.1 15.8 1.0
CD2 B:HIS10 3.2 10.3 1.0
CD2 F:HIS10 3.2 11.3 1.0
ND1 J:HIS10 4.1 11.2 1.0
ND1 B:HIS10 4.2 13.8 1.0
ND1 F:HIS10 4.2 19.3 1.0
CG J:HIS10 4.2 16.3 1.0
CG B:HIS10 4.3 18.0 1.0
CG F:HIS10 4.3 18.7 1.0
O F:LEU6 4.7 18.0 1.0
O B:LEU6 4.8 18.9 1.0
O J:LEU6 4.9 15.9 1.0
CB B:LEU6 4.9 15.9 1.0

Zinc binding site 2 out of 2 in 1qiy

Go back to Zinc Binding Sites List in 1qiy
Zinc binding site 2 out of 2 in the Human Insulin Hexamers with Chain B His Mutated to Tyr Complexed with Phenol


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Human Insulin Hexamers with Chain B His Mutated to Tyr Complexed with Phenol within 5.0Å range:
probe atom residue distance (Å) B Occ
L:Zn1001

b:20.4
occ:1.00
NE2 L:HIS10 2.1 22.8 1.0
NE2 H:HIS10 2.1 23.4 1.0
NE2 D:HIS10 2.1 20.3 1.0
CL L:CL1002 2.2 19.1 1.0
CE1 L:HIS10 3.0 15.0 1.0
CE1 D:HIS10 3.0 14.5 1.0
CD2 L:HIS10 3.1 22.8 1.0
CE1 H:HIS10 3.1 19.0 1.0
CD2 H:HIS10 3.1 19.4 1.0
CD2 D:HIS10 3.2 14.2 1.0
ND1 L:HIS10 4.1 22.7 1.0
ND1 D:HIS10 4.2 21.1 1.0
CG L:HIS10 4.2 23.5 1.0
ND1 H:HIS10 4.2 18.7 1.0
CG H:HIS10 4.3 27.8 1.0
CG D:HIS10 4.3 17.9 1.0
O L:LEU6 4.9 19.9 1.0
O D:LEU6 4.9 22.3 1.0
O H:LEU6 4.9 21.8 1.0
CB L:LEU6 5.0 17.6 1.0

Reference:

L.Tang, J.L.Whittingham, C.S.Verma, L.S.D.Caves, G.G.Dodson. Structural Consequences of the B5 Histidine --> Tyrosine Mutation in Human Insulin Characterized By X-Ray Crystallography and Conformational Analysis. Biochemistry V. 38 12041 1999.
ISSN: ISSN 0006-2960
PubMed: 10508408
DOI: 10.1021/BI990700K
Page generated: Wed Dec 16 03:01:54 2020

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