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Zinc in PDB 1qf2: Thermolysin (E.C.3.4.24.27) Complexed with (2-Sulphanyl-3- Phenylpropanoyl)-Gly-(5-Phenylproline). Parameters For Zn- Monodentation of Mercaptoacyldipeptides in Metalloendopeptidase
Enzymatic activity of Thermolysin (E.C.3.4.24.27) Complexed with (2-Sulphanyl-3- Phenylpropanoyl)-Gly-(5-Phenylproline). Parameters For Zn- Monodentation of Mercaptoacyldipeptides in Metalloendopeptidase
All present enzymatic activity of Thermolysin (E.C.3.4.24.27) Complexed with (2-Sulphanyl-3- Phenylpropanoyl)-Gly-(5-Phenylproline). Parameters For Zn- Monodentation of Mercaptoacyldipeptides in Metalloendopeptidase:
3.4.24.27;
3.4.24.27;
Protein crystallography data
The structure of Thermolysin (E.C.3.4.24.27) Complexed with (2-Sulphanyl-3- Phenylpropanoyl)-Gly-(5-Phenylproline). Parameters For Zn- Monodentation of Mercaptoacyldipeptides in Metalloendopeptidase, PDB code: 1qf2
was solved by
J.-F.Gaucher,
M.Selkti,
G.Tiraboschi,
T.Prange,
B.P.Roques,
A.Tomas,
M.C.Fournie-Zaluski,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 10.00 / 2.06 |
| Space group | P 61 2 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 93.500, 93.500, 131.300, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 15.9 / 22.2 |
Other elements in 1qf2:
The structure of Thermolysin (E.C.3.4.24.27) Complexed with (2-Sulphanyl-3- Phenylpropanoyl)-Gly-(5-Phenylproline). Parameters For Zn- Monodentation of Mercaptoacyldipeptides in Metalloendopeptidase also contains other interesting chemical elements:
| Calcium | (Ca) | 4 atoms |
Zinc Binding Sites:
The binding sites of Zinc atom in the Thermolysin (E.C.3.4.24.27) Complexed with (2-Sulphanyl-3- Phenylpropanoyl)-Gly-(5-Phenylproline). Parameters For Zn- Monodentation of Mercaptoacyldipeptides in Metalloendopeptidase
(pdb code 1qf2). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Thermolysin (E.C.3.4.24.27) Complexed with (2-Sulphanyl-3- Phenylpropanoyl)-Gly-(5-Phenylproline). Parameters For Zn- Monodentation of Mercaptoacyldipeptides in Metalloendopeptidase, PDB code: 1qf2:
In total only one binding site of Zinc was determined in the Thermolysin (E.C.3.4.24.27) Complexed with (2-Sulphanyl-3- Phenylpropanoyl)-Gly-(5-Phenylproline). Parameters For Zn- Monodentation of Mercaptoacyldipeptides in Metalloendopeptidase, PDB code: 1qf2:
Zinc binding site 1 out of 1 in 1qf2
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Zinc Binding Sites List in 1qf2
Zinc binding site 1 out
of 1 in the Thermolysin (E.C.3.4.24.27) Complexed with (2-Sulphanyl-3- Phenylpropanoyl)-Gly-(5-Phenylproline). Parameters For Zn- Monodentation of Mercaptoacyldipeptides in Metalloendopeptidase
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Thermolysin (E.C.3.4.24.27) Complexed with (2-Sulphanyl-3- Phenylpropanoyl)-Gly-(5-Phenylproline). Parameters For Zn- Monodentation of Mercaptoacyldipeptides in Metalloendopeptidase within 5.0Å range:
|
Reference:
J.F.Gaucher,
M.Selkti,
G.Tiraboschi,
T.Prange,
B.P.Roques,
A.Tomas,
M.C.Fournie-Zaluski.
Crystal Structures of Alpha-Mercaptoacyldipeptides in the Thermolysin Active Site: Structural Parameters For A Zn Monodentation or Bidentation in Metalloendopeptidases. Biochemistry V. 38 12569 1999.
ISSN: ISSN 0006-2960
PubMed: 10504225
DOI: 10.1021/BI991043Z
Page generated: Wed Oct 16 18:08:24 2024
ISSN: ISSN 0006-2960
PubMed: 10504225
DOI: 10.1021/BI991043Z
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