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Zinc in PDB 1q2o: Bovine Endothelial Nitric Oxide Synthase N368D Mutant Heme Domain Dimer with L-N(Omega)-Nitroarginine-2,4-L-Diaminobutyramide Bound

Enzymatic activity of Bovine Endothelial Nitric Oxide Synthase N368D Mutant Heme Domain Dimer with L-N(Omega)-Nitroarginine-2,4-L-Diaminobutyramide Bound

All present enzymatic activity of Bovine Endothelial Nitric Oxide Synthase N368D Mutant Heme Domain Dimer with L-N(Omega)-Nitroarginine-2,4-L-Diaminobutyramide Bound:
1.14.13.39;

Protein crystallography data

The structure of Bovine Endothelial Nitric Oxide Synthase N368D Mutant Heme Domain Dimer with L-N(Omega)-Nitroarginine-2,4-L-Diaminobutyramide Bound, PDB code: 1q2o was solved by M.L.Flinspach, H.Li, J.Jamal, W.Yang, H.Huang, J.M.Hah, J.A.Gomez-Vidal, E.A.Litzinger, R.B.Silverman, T.L.Poulos, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 48.44 / 1.74
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 57.908, 106.989, 156.989, 90.00, 90.00, 90.00
R / Rfree (%) 19.3 / 22

Other elements in 1q2o:

The structure of Bovine Endothelial Nitric Oxide Synthase N368D Mutant Heme Domain Dimer with L-N(Omega)-Nitroarginine-2,4-L-Diaminobutyramide Bound also contains other interesting chemical elements:

Arsenic (As) 2 atoms
Iron (Fe) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Bovine Endothelial Nitric Oxide Synthase N368D Mutant Heme Domain Dimer with L-N(Omega)-Nitroarginine-2,4-L-Diaminobutyramide Bound (pdb code 1q2o). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Bovine Endothelial Nitric Oxide Synthase N368D Mutant Heme Domain Dimer with L-N(Omega)-Nitroarginine-2,4-L-Diaminobutyramide Bound, PDB code: 1q2o:

Zinc binding site 1 out of 1 in 1q2o

Go back to Zinc Binding Sites List in 1q2o
Zinc binding site 1 out of 1 in the Bovine Endothelial Nitric Oxide Synthase N368D Mutant Heme Domain Dimer with L-N(Omega)-Nitroarginine-2,4-L-Diaminobutyramide Bound


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Bovine Endothelial Nitric Oxide Synthase N368D Mutant Heme Domain Dimer with L-N(Omega)-Nitroarginine-2,4-L-Diaminobutyramide Bound within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn900

b:20.6
occ:1.00
 SG B:CYS101 2.3 18.4 1.0
SG A:CYS96 2.3 19.5 1.0
SG B:CYS96 2.4 19.4 1.0
SG A:CYS101 2.4 18.8 1.0
CB B:CYS101 3.2 18.1 1.0
CB A:CYS101 3.3 20.1 1.0
CB A:CYS96 3.4 20.5 1.0
CB B:CYS96 3.4 19.8 1.0
CA B:CYS101 3.7 16.8 1.0
CA A:CYS101 3.7 19.5 1.0
N A:GLY103 4.1 19.4 1.0
N B:GLY103 4.1 16.5 1.0
N B:LEU102 4.2 18.0 1.0
N A:LEU102 4.2 17.9 1.0
C B:CYS101 4.3 18.9 1.0
C A:CYS101 4.3 19.1 1.0
CA B:GLY103 4.4 18.2 1.0
CA A:GLY103 4.4 19.9 1.0
CA A:CYS96 4.8 22.2 1.0
CA B:CYS96 4.8 20.4 1.0
O A:HOH1004 4.8 28.8 1.0
N A:CYS101 5.0 19.8 1.0
N B:CYS101 5.0 18.3 1.0

Reference:

M.L.Flinspach, H.Li, J.Jamal, W.Yang, H.Huang, J.M.Hah, J.A.Gomez-Vidal, E.A.Litzinger, R.B.Silverman, T.L.Poulos. Structural Basis For Dipeptide Amide Isoform-Selective Inhibition of Neuronal Nitric Oxide Synthase. Nat.Struct.Mol.Biol. V. 11 54 2004.
ISSN: ISSN 1545-9993
PubMed: 14718923
DOI: 10.1038/NSMB704
Page generated: Wed Oct 16 18:00:55 2024

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