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Zinc in PDB 1ptr: Protein Kinase C Delta CYS2 Domain Complexed with Phorbol- 13-Acetate

Protein crystallography data

The structure of Protein Kinase C Delta CYS2 Domain Complexed with Phorbol- 13-Acetate, PDB code: 1ptr was solved by G.Zhang, J.H.Hurley, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 6.00 / 2.20
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 32.400, 63.500, 65.500, 90.00, 90.00, 90.00
R / Rfree (%) 19.4 / n/a

Zinc Binding Sites:

The binding sites of Zinc atom in the Protein Kinase C Delta CYS2 Domain Complexed with Phorbol- 13-Acetate (pdb code 1ptr). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Protein Kinase C Delta CYS2 Domain Complexed with Phorbol- 13-Acetate, PDB code: 1ptr:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 1ptr

Go back to Zinc Binding Sites List in 1ptr
Zinc binding site 1 out of 2 in the Protein Kinase C Delta CYS2 Domain Complexed with Phorbol- 13-Acetate


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Protein Kinase C Delta CYS2 Domain Complexed with Phorbol- 13-Acetate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1

b:19.8
occ:1.00
ND1 A:HIS231 2.0 9.2 1.0
SG A:CYS261 2.3 17.3 1.0
SG A:CYS264 2.3 16.3 1.0
SG A:CYS280 2.3 17.3 1.0
CE1 A:HIS231 3.0 13.3 1.0
CG A:HIS231 3.1 12.4 1.0
CB A:CYS261 3.2 16.2 1.0
CB A:CYS264 3.3 15.9 1.0
CB A:CYS280 3.3 16.0 1.0
CB A:HIS231 3.6 11.4 1.0
N A:CYS264 3.7 17.1 1.0
CA A:HIS231 3.8 17.3 1.0
CA A:CYS264 4.0 16.9 1.0
NE2 A:HIS231 4.1 10.7 1.0
CA A:CYS280 4.1 20.6 1.0
CD2 A:HIS231 4.2 12.9 1.0
N A:HIS231 4.6 19.5 1.0
CB A:ASP263 4.6 18.0 1.0
CA A:CYS261 4.6 17.0 1.0
C A:ASP263 4.6 18.6 1.0
N A:ARG232 4.7 16.9 1.0
C A:CYS264 4.8 17.7 1.0
CB A:MET266 4.8 9.4 1.0
C A:HIS231 4.9 17.9 1.0
N A:ASP263 4.9 19.4 1.0
CA A:ASP263 4.9 19.7 1.0

Zinc binding site 2 out of 2 in 1ptr

Go back to Zinc Binding Sites List in 1ptr
Zinc binding site 2 out of 2 in the Protein Kinase C Delta CYS2 Domain Complexed with Phorbol- 13-Acetate


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Protein Kinase C Delta CYS2 Domain Complexed with Phorbol- 13-Acetate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn2

b:13.7
occ:1.00
ND1 A:HIS269 2.0 11.7 1.0
SG A:CYS272 2.3 10.8 1.0
SG A:CYS247 2.3 9.3 1.0
SG A:CYS244 2.3 10.0 1.0
CE1 A:HIS269 2.9 8.4 1.0
CG A:HIS269 3.1 10.3 1.0
CB A:CYS244 3.2 9.0 1.0
CB A:CYS247 3.3 9.7 1.0
CB A:CYS272 3.3 12.4 1.0
CB A:HIS269 3.5 9.4 1.0
N A:CYS247 3.9 9.8 1.0
NE2 A:HIS269 4.1 2.3 1.0
N A:HIS269 4.1 10.2 1.0
CA A:CYS247 4.1 8.9 1.0
CD2 A:HIS269 4.2 4.2 1.0
CA A:HIS269 4.4 10.5 1.0
CA A:CYS244 4.6 13.4 1.0
CA A:CYS272 4.6 16.1 1.0
CD2 A:HIS246 4.8 13.0 1.0
CE A:LYS271 4.8 16.4 1.0
C A:CYS247 4.8 7.9 1.0
N A:CYS272 4.9 15.3 1.0
CB A:HIS246 4.9 10.7 1.0
CG A:LYS271 4.9 17.3 1.0
O A:SER249 5.0 12.2 1.0
C A:HIS246 5.0 8.7 1.0

Reference:

G.Zhang, M.G.Kazanietz, P.M.Blumberg, J.H.Hurley. Crystal Structure of the CYS2 Activator-Binding Domain of Protein Kinase C Delta in Complex with Phorbol Ester. Cell(Cambridge,Mass.) V. 81 917 1995.
ISSN: ISSN 0092-8674
PubMed: 7781068
DOI: 10.1016/0092-8674(95)90011-X
Page generated: Mon Jan 25 16:11:43 2021

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