Zinc in PDB 1oxq: Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (Ml-Iap)

The structure of Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (Ml-Iap), PDB code: 1oxq was solved by M.C.Franklin, S.Kadkhodayan, H.Ackerly, D.Alexandru, M.D.Distefano, L.O.Elliott, J.A.Flygare, D.Vucic, K.Deshayes, W.J.Fairbrother, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 2.30
Space group	P 32
Cell size a, b, c (Å), α, β, γ (°)	83.189, 83.189, 93.612, 90.00, 90.00, 120.00
R / Rfree (%)	16.1 / 21.8

The binding sites of Zinc atom in the Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (Ml-Iap) (pdb code 1oxq). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 5 binding sites of Zinc where determined in the Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (Ml-Iap), PDB code: 1oxq:
Jump to Zinc binding site number: 1; 2; 3; 4; 5;

Zinc binding site 1 out of 5 in the Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (Ml-Iap)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (Ml-Iap) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1001 b:47.6 occ:1.00 SG A:CYS151 2.2 34.8 1.0 NE2 A:HIS144 2.2 45.1 1.0 SG A:CYS127 2.3 31.9 1.0 SG A:CYS124 2.5 31.1 1.0 CB A:CYS151 3.0 34.0 1.0 CE1 A:HIS144 3.0 42.9 1.0 CB A:CYS124 3.1 18.8 1.0 CB A:CYS127 3.1 28.5 1.0 CD2 A:HIS144 3.4 44.0 1.0 N A:CYS127 3.6 26.9 1.0 CA A:CYS127 3.9 30.3 1.0 ND1 A:HIS144 4.2 42.7 1.0 CA A:CYS151 4.3 39.8 1.0 CG A:HIS144 4.4 44.7 1.0 CB A:PHE126 4.5 35.5 1.0 CA A:CYS124 4.6 26.5 1.0 C A:PHE126 4.7 31.5 1.0 C A:CYS127 4.7 32.3 1.0 CB A:PHE148 4.7 28.2 1.0 N A:TYR128 4.8 30.7 1.0 N A:PHE126 4.9 34.8 1.0 CA A:PHE126 4.9 33.3 1.0 CB A:PHE153 4.9 38.7 1.0 N A:LEU154 5.0 42.5 1.0

Zinc binding site 2 out of 5 in the Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (Ml-Iap)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (Ml-Iap) within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1002 b:30.3 occ:1.00 NE2 B:HIS144 2.1 20.5 1.0 SG B:CYS151 2.2 21.2 1.0 SG B:CYS127 2.3 21.4 1.0 SG B:CYS124 2.4 21.3 1.0 CE1 B:HIS144 2.9 19.9 1.0 CB B:CYS151 3.0 19.6 1.0 CB B:CYS124 3.1 16.3 1.0 CD2 B:HIS144 3.2 16.4 1.0 CB B:CYS127 3.3 17.5 1.0 N B:CYS127 3.6 20.0 1.0 CA B:CYS127 4.0 23.5 1.0 ND1 B:HIS144 4.1 18.6 1.0 CG B:HIS144 4.2 15.5 1.0 CA B:CYS151 4.4 19.9 1.0 CA B:CYS124 4.5 21.1 1.0 CB B:PHE126 4.6 21.9 1.0 C B:PHE126 4.7 24.0 1.0 CB B:PHE148 4.8 19.7 1.0 C B:CYS127 4.8 22.6 1.0 CB B:LEU154 4.9 19.5 1.0 N B:TYR128 4.9 22.0 1.0 N B:PHE126 4.9 20.2 1.0 CA B:PHE126 4.9 18.9 1.0 N B:LEU154 5.0 16.9 1.0

Zinc binding site 3 out of 5 in the Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (Ml-Iap)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (Ml-Iap) within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn1003 b:32.3 occ:1.00 NE2 C:HIS144 2.1 20.8 1.0 SG C:CYS151 2.3 21.2 1.0 SG C:CYS127 2.3 23.9 1.0 SG C:CYS124 2.3 25.4 1.0 CE1 C:HIS144 2.9 20.6 1.0 CB C:CYS151 3.0 18.0 1.0 CB C:CYS124 3.1 19.0 1.0 CD2 C:HIS144 3.2 20.5 1.0 CB C:CYS127 3.3 20.9 1.0 N C:CYS127 3.6 23.9 1.0 CA C:CYS127 4.0 24.1 1.0 ND1 C:HIS144 4.1 20.1 1.0 CG C:HIS144 4.3 23.6 1.0 CA C:CYS151 4.4 22.2 1.0 CA C:CYS124 4.5 24.2 1.0 CB C:PHE126 4.6 20.1 1.0 C C:PHE126 4.7 23.2 1.0 CB C:PHE148 4.7 22.2 1.0 C C:CYS127 4.8 24.4 1.0 N C:TYR128 4.9 25.4 1.0 N C:PHE126 4.9 24.2 1.0 CB C:LEU154 4.9 19.6 1.0 CA C:PHE126 5.0 22.7 1.0

Zinc binding site 4 out of 5 in the Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (Ml-Iap)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (Ml-Iap) within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn1004 b:36.2 occ:1.00 NE2 D:HIS144 2.1 25.8 1.0 SG D:CYS127 2.3 23.4 1.0 SG D:CYS151 2.4 27.0 1.0 SG D:CYS124 2.4 24.8 1.0 CE1 D:HIS144 2.8 26.5 1.0 CB D:CYS124 3.0 16.0 1.0 CB D:CYS151 3.1 16.8 1.0 CD2 D:HIS144 3.2 24.2 1.0 CB D:CYS127 3.3 25.1 1.0 N D:CYS127 3.6 20.2 1.0 CA D:CYS127 4.0 24.3 1.0 ND1 D:HIS144 4.0 24.4 1.0 CG D:HIS144 4.3 23.3 1.0 CB D:PHE126 4.4 26.2 1.0 CA D:CYS151 4.5 22.4 1.0 CA D:CYS124 4.5 19.9 1.0 C D:PHE126 4.6 23.2 1.0 CB D:PHE148 4.8 32.1 1.0 C D:CYS127 4.8 27.3 1.0 CA D:PHE126 4.8 24.4 1.0 N D:PHE126 4.9 28.0 1.0 N D:TYR128 4.9 27.5 1.0 CB D:LEU154 4.9 23.1 1.0

Zinc binding site 5 out of 5 in the Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (Ml-Iap)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (Ml-Iap) within 5.0Å range: probe atom residue distance (Å) B Occ E:Zn1005 b:34.0 occ:1.00 NE2 E:HIS144 2.0 28.1 1.0 SG E:CYS127 2.3 24.9 1.0 SG E:CYS151 2.3 23.9 1.0 SG E:CYS124 2.4 24.6 1.0 CE1 E:HIS144 2.7 27.0 1.0 CB E:CYS124 3.0 19.6 1.0 CB E:CYS151 3.1 26.0 1.0 CB E:CYS127 3.2 21.5 1.0 CD2 E:HIS144 3.2 25.8 1.0 N E:CYS127 3.6 21.4 1.0 ND1 E:HIS144 4.0 27.4 1.0 CA E:CYS127 4.0 26.9 1.0 CG E:HIS144 4.2 27.9 1.0 CA E:CYS151 4.5 25.7 1.0 CA E:CYS124 4.5 21.1 1.0 CB E:PHE126 4.6 20.9 1.0 C E:PHE126 4.7 23.3 1.0 CB E:PHE148 4.8 26.0 1.0 C E:CYS127 4.8 26.0 1.0 N E:PHE126 4.9 23.6 1.0 CA E:PHE126 4.9 22.1 1.0 N E:TYR128 4.9 23.9 1.0

M.C.Franklin, S.Kadkhodayan, H.Ackerly, D.Alexandru, M.D.Distefano, L.O.Elliott, J.A.Flygare, G.Mausisa, D.C.Okawa, D.Ong, D.Vucic, K.Deshayes, W.J.Fairbrother. Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (Ml-Iap) Biochemistry V. 42 8223 2003.
ISSN: ISSN 0006-2960
PubMed: 12846571
DOI: 10.1021/BI034227T