Zinc in PDB 1oxn: Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (Ml-Iap)

The structure of Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (Ml-Iap), PDB code: 1oxn was solved by M.C.Franklin, S.Kadkhodayan, H.Ackerly, D.Alexandru, M.D.Distefano, L.O.Elliott, J.A.Flygare, D.Vucic, K.Deshayes, W.J.Fairbrother, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 2.20
Space group	P 32
Cell size a, b, c (Å), α, β, γ (°)	82.770, 82.770, 93.170, 90.00, 90.00, 120.00
R / Rfree (%)	16.9 / 22.5

The binding sites of Zinc atom in the Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (Ml-Iap) (pdb code 1oxn). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 5 binding sites of Zinc where determined in the Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (Ml-Iap), PDB code: 1oxn:
Jump to Zinc binding site number: 1; 2; 3; 4; 5;

Zinc binding site 1 out of 5 in the Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (Ml-Iap)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (Ml-Iap) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1001 b:42.4 occ:1.00 NE2 A:HIS144 2.2 38.9 1.0 SG A:CYS151 2.2 31.0 1.0 SG A:CYS127 2.3 26.8 1.0 SG A:CYS124 2.4 27.8 1.0 CB A:CYS151 3.0 28.6 1.0 CE1 A:HIS144 3.0 34.5 1.0 CB A:CYS124 3.1 19.5 1.0 CB A:CYS127 3.1 24.0 1.0 CD2 A:HIS144 3.2 37.0 1.0 N A:CYS127 3.5 23.7 1.0 CA A:CYS127 3.9 28.6 1.0 ND1 A:HIS144 4.2 36.8 1.0 CG A:HIS144 4.3 38.0 1.0 CA A:CYS151 4.3 31.4 1.0 CB A:PHE126 4.6 30.9 1.0 CA A:CYS124 4.6 25.8 1.0 C A:PHE126 4.7 28.6 1.0 CB A:PHE148 4.7 27.9 1.0 C A:CYS127 4.7 27.9 1.0 N A:TYR128 4.8 26.6 1.0 CB A:PHE153 4.9 35.4 1.0 N A:PHE126 4.9 30.5 1.0 CA A:PHE126 4.9 29.4 1.0 CB A:LEU154 4.9 36.6 1.0 N A:LEU154 4.9 37.0 1.0

Zinc binding site 2 out of 5 in the Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (Ml-Iap)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (Ml-Iap) within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1002 b:26.4 occ:1.00 NE2 B:HIS144 2.1 20.7 1.0 SG B:CYS151 2.2 17.2 1.0 SG B:CYS127 2.3 17.1 1.0 SG B:CYS124 2.4 18.5 1.0 CE1 B:HIS144 2.9 16.2 1.0 CB B:CYS151 3.0 16.9 1.0 CB B:CYS124 3.1 15.3 1.0 CD2 B:HIS144 3.2 17.3 1.0 CB B:CYS127 3.2 14.7 1.0 N B:CYS127 3.5 15.1 1.0 CA B:CYS127 4.0 16.4 1.0 ND1 B:HIS144 4.1 18.8 1.0 CG B:HIS144 4.2 14.3 1.0 CA B:CYS151 4.4 18.8 1.0 CA B:CYS124 4.5 18.4 1.0 CB B:PHE126 4.6 17.1 1.0 C B:PHE126 4.6 21.2 1.0 CB B:PHE148 4.7 18.0 1.0 C B:CYS127 4.8 19.2 1.0 CB B:LEU154 4.8 16.8 1.0 N B:PHE126 4.9 15.4 1.0 N B:TYR128 4.9 18.7 1.0 CA B:PHE126 4.9 18.3 1.0 N B:LEU154 5.0 14.6 1.0

Zinc binding site 3 out of 5 in the Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (Ml-Iap)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (Ml-Iap) within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn1003 b:29.2 occ:1.00 NE2 C:HIS144 2.0 17.1 1.0 SG C:CYS151 2.3 17.7 1.0 SG C:CYS127 2.3 19.5 1.0 SG C:CYS124 2.3 19.3 1.0 CE1 C:HIS144 2.8 18.7 1.0 CB C:CYS151 3.1 15.3 1.0 CB C:CYS124 3.1 16.8 1.0 CD2 C:HIS144 3.2 16.0 1.0 CB C:CYS127 3.2 17.0 1.0 N C:CYS127 3.6 17.7 1.0 ND1 C:HIS144 4.0 15.8 1.0 CA C:CYS127 4.0 18.9 1.0 CG C:HIS144 4.2 17.3 1.0 CA C:CYS151 4.4 18.4 1.0 CA C:CYS124 4.5 18.9 1.0 CB C:PHE126 4.6 19.8 1.0 CB C:PHE148 4.7 17.5 1.0 C C:PHE126 4.7 19.6 1.0 C C:CYS127 4.8 20.6 1.0 N C:TYR128 4.8 21.1 1.0 CB C:LEU154 4.9 17.7 1.0 N C:PHE126 4.9 19.4 1.0 CA C:PHE126 4.9 20.8 1.0

Zinc binding site 4 out of 5 in the Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (Ml-Iap)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (Ml-Iap) within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn1004 b:32.4 occ:1.00 NE2 D:HIS144 2.0 19.6 1.0 SG D:CYS127 2.2 18.7 1.0 SG D:CYS151 2.4 23.6 1.0 SG D:CYS124 2.4 21.9 1.0 CE1 D:HIS144 2.9 21.5 1.0 CB D:CYS124 3.0 15.9 1.0 CB D:CYS151 3.1 19.0 1.0 CD2 D:HIS144 3.1 17.7 1.0 CB D:CYS127 3.3 23.2 1.0 N D:CYS127 3.5 19.9 1.0 CA D:CYS127 4.0 22.5 1.0 ND1 D:HIS144 4.0 20.4 1.0 CG D:HIS144 4.2 18.7 1.0 CA D:CYS151 4.4 20.3 1.0 CB D:PHE126 4.5 27.5 1.0 CA D:CYS124 4.5 17.4 1.0 C D:PHE126 4.6 21.3 1.0 CB D:PHE148 4.7 27.4 1.0 C D:CYS127 4.8 25.0 1.0 CA D:PHE126 4.8 21.5 1.0 N D:TYR128 4.9 24.4 1.0 N D:PHE126 4.9 26.2 1.0 CB D:LEU154 4.9 20.9 1.0 CD2 D:PHE148 4.9 27.7 1.0

Zinc binding site 5 out of 5 in the Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (Ml-Iap)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (Ml-Iap) within 5.0Å range: probe atom residue distance (Å) B Occ E:Zn1005 b:30.1 occ:1.00 NE2 E:HIS144 2.0 20.1 1.0 SG E:CYS127 2.3 21.7 1.0 SG E:CYS151 2.3 19.7 1.0 SG E:CYS124 2.4 20.0 1.0 CE1 E:HIS144 2.8 20.0 1.0 CB E:CYS124 3.0 13.5 1.0 CB E:CYS151 3.0 22.5 1.0 CB E:CYS127 3.2 20.0 1.0 CD2 E:HIS144 3.2 15.6 1.0 N E:CYS127 3.5 17.2 1.0 CA E:CYS127 3.9 21.8 1.0 ND1 E:HIS144 4.0 18.5 1.0 CG E:HIS144 4.2 19.6 1.0 CA E:CYS151 4.4 23.8 1.0 CA E:CYS124 4.5 15.5 1.0 CB E:PHE126 4.6 18.5 1.0 C E:PHE126 4.6 17.0 1.0 C E:CYS127 4.8 22.2 1.0 N E:PHE126 4.8 19.9 1.0 CB E:PHE148 4.8 24.2 1.0 CA E:PHE126 4.8 17.8 1.0 N E:TYR128 4.9 19.7 1.0 C E:CYS124 4.9 17.5 1.0

M.C.Franklin, S.Kadkhodayan, H.Ackerly, D.Alexandru, M.D.Distefano, L.O.Elliott, J.A.Flygare, G.Mausisa, D.C.Okawa, D.Ong, D.Vucic, K.Deshayes, W.J.Fairbrother. Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (Ml-Iap) Biochemistry V. 42 8223 2003.
ISSN: ISSN 0006-2960
PubMed: 12846571
DOI: 10.1021/BI034227T