Atomistry » Zinc » PDB 1oht-1p0f » 1okm
Atomistry »
  Zinc »
    PDB 1oht-1p0f »
      1okm »

Zinc in PDB 1okm: Carbonic Anhydrase II Complex with the 1OKM Inhibitor 4- Sulfonamide-[1-(4-Aminobutane)]Benzamide

Enzymatic activity of Carbonic Anhydrase II Complex with the 1OKM Inhibitor 4- Sulfonamide-[1-(4-Aminobutane)]Benzamide

All present enzymatic activity of Carbonic Anhydrase II Complex with the 1OKM Inhibitor 4- Sulfonamide-[1-(4-Aminobutane)]Benzamide:
4.2.1.1;

Protein crystallography data

The structure of Carbonic Anhydrase II Complex with the 1OKM Inhibitor 4- Sulfonamide-[1-(4-Aminobutane)]Benzamide, PDB code: 1okm was solved by D.Elbaum, S.K.Nair, M.W.Patchan, R.B.Thompson, D.W.Christianson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) N/A / 2.20
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 42.700, 41.700, 73.000, 90.00, 104.60, 90.00
R / Rfree (%) 16.2 / 21.7

Other elements in 1okm:

The structure of Carbonic Anhydrase II Complex with the 1OKM Inhibitor 4- Sulfonamide-[1-(4-Aminobutane)]Benzamide also contains other interesting chemical elements:

Mercury (Hg) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Carbonic Anhydrase II Complex with the 1OKM Inhibitor 4- Sulfonamide-[1-(4-Aminobutane)]Benzamide (pdb code 1okm). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Carbonic Anhydrase II Complex with the 1OKM Inhibitor 4- Sulfonamide-[1-(4-Aminobutane)]Benzamide, PDB code: 1okm:

Zinc binding site 1 out of 1 in 1okm

Go back to Zinc Binding Sites List in 1okm
Zinc binding site 1 out of 1 in the Carbonic Anhydrase II Complex with the 1OKM Inhibitor 4- Sulfonamide-[1-(4-Aminobutane)]Benzamide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Carbonic Anhydrase II Complex with the 1OKM Inhibitor 4- Sulfonamide-[1-(4-Aminobutane)]Benzamide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn262

b:8.3
occ:1.00
 NE2 A:HIS96 2.0 2.0 1.0
ND1 A:HIS119 2.0 8.3 1.0
NE2 A:HIS94 2.0 4.2 1.0
N3S A:SAB555 2.1 11.7 1.0
CD2 A:HIS94 2.7 2.0 1.0
CE1 A:HIS119 2.8 7.6 1.0
CD2 A:HIS96 2.8 2.1 1.0
S A:SAB555 3.1 9.9 1.0
CG A:HIS119 3.1 9.2 1.0
O2S A:SAB555 3.1 12.0 1.0
CE1 A:HIS96 3.1 4.9 1.0
CE1 A:HIS94 3.3 5.5 1.0
CB A:HIS119 3.6 6.1 1.0
OG1 A:THR199 3.8 7.0 1.0
OE1 A:GLU106 3.9 3.7 1.0
NE2 A:HIS119 4.0 7.5 1.0
CG A:HIS94 4.0 2.8 1.0
O1S A:SAB555 4.0 9.8 1.0
CG A:HIS96 4.0 3.3 1.0
C4 A:SAB555 4.1 12.2 1.0
ND1 A:HIS96 4.2 5.1 1.0
CD2 A:HIS119 4.2 5.5 1.0
ND1 A:HIS94 4.2 2.7 1.0
C3 A:SAB555 4.7 12.9 1.0
CD A:GLU106 4.9 6.7 1.0

Reference:

D.Elbaum, S.K.Nair, M.W.Patchan, R.B.Thompson, D.W.Christianson. Structure-Based Design of A Sulfonamide Probe For Fluorescence Anisotropy Detection of Zinc with A Carbonic Anhydrase-Based Biosensor. J.Am.Chem.Soc. V. 118 8381 1996.
ISSN: ISSN 0002-7863
Page generated: Wed Dec 16 02:59:47 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy