Atomistry » Zinc » PDB 1my0-1ndv » 1n92
Atomistry »
  Zinc »
    PDB 1my0-1ndv »
      1n92 »

Zinc in PDB 1n92: Horse Liver Alcohol Dehydrogenase Complexed with Nad+ and 4- Iodopyrazole

Enzymatic activity of Horse Liver Alcohol Dehydrogenase Complexed with Nad+ and 4- Iodopyrazole

All present enzymatic activity of Horse Liver Alcohol Dehydrogenase Complexed with Nad+ and 4- Iodopyrazole:
1.1.1.1;

Protein crystallography data

The structure of Horse Liver Alcohol Dehydrogenase Complexed with Nad+ and 4- Iodopyrazole, PDB code: 1n92 was solved by J.K.Rubach, B.V.Plapp, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 1.47
Space group P 1
Cell size a, b, c (Å), α, β, γ (°) 44.200, 51.050, 93.230, 78.96, 75.47, 70.24
R / Rfree (%) 15.1 / 18.3

Other elements in 1n92:

The structure of Horse Liver Alcohol Dehydrogenase Complexed with Nad+ and 4- Iodopyrazole also contains other interesting chemical elements:

Iodine (I) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Horse Liver Alcohol Dehydrogenase Complexed with Nad+ and 4- Iodopyrazole (pdb code 1n92). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Horse Liver Alcohol Dehydrogenase Complexed with Nad+ and 4- Iodopyrazole, PDB code: 1n92:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in 1n92

Go back to Zinc Binding Sites List in 1n92
Zinc binding site 1 out of 4 in the Horse Liver Alcohol Dehydrogenase Complexed with Nad+ and 4- Iodopyrazole


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Horse Liver Alcohol Dehydrogenase Complexed with Nad+ and 4- Iodopyrazole within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn375

b:22.1
occ:1.00
 NE2 A:HIS67 2.0 17.4 1.0
N1 A:PYZ378 2.2 18.6 1.0
SG A:CYS174 2.2 18.6 1.0
SG A:CYS46 2.3 20.2 1.0
CD2 A:HIS67 3.0 18.6 1.0
CE1 A:HIS67 3.1 18.5 1.0
C5 A:PYZ378 3.1 19.9 1.0
N2 A:PYZ378 3.2 19.3 1.0
C5N A:NAJ377 3.2 15.4 1.0
CB A:CYS46 3.3 18.3 1.0
CB A:CYS174 3.4 15.5 1.0
C4N A:NAJ377 3.7 16.0 1.0
C6N A:NAJ377 4.1 14.6 1.0
OG A:SER48 4.1 18.6 1.0
CG A:HIS67 4.1 17.0 1.0
ND1 A:HIS67 4.2 17.3 1.0
CB A:SER48 4.2 19.1 1.0
C4 A:PYZ378 4.3 19.3 1.0
C3 A:PYZ378 4.4 20.6 1.0
NH2 A:ARG369 4.5 20.1 1.0
CE2 A:PHE93 4.5 14.7 1.0
CA A:CYS174 4.7 16.0 1.0
CZ A:PHE93 4.8 15.5 1.0
CA A:CYS46 4.8 19.5 1.0
OE2 A:GLU68 4.9 19.6 1.0

Zinc binding site 2 out of 4 in 1n92

Go back to Zinc Binding Sites List in 1n92
Zinc binding site 2 out of 4 in the Horse Liver Alcohol Dehydrogenase Complexed with Nad+ and 4- Iodopyrazole


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Horse Liver Alcohol Dehydrogenase Complexed with Nad+ and 4- Iodopyrazole within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn376

b:20.1
occ:1.00
 SG A:CYS100 2.3 19.6 1.0
SG A:CYS97 2.3 21.0 1.0
SG A:CYS111 2.3 18.1 1.0
SG A:CYS103 2.4 16.7 1.0
CB A:CYS111 3.3 16.6 1.0
CB A:CYS100 3.4 19.8 1.0
CB A:CYS103 3.4 17.7 1.0
CB A:CYS97 3.4 18.4 1.0
N A:CYS97 3.5 17.4 1.0
CA A:CYS111 3.8 16.8 1.0
N A:CYS100 3.8 21.1 1.0
CA A:CYS97 3.9 19.7 1.0
N A:LEU112 3.9 16.9 1.0
N A:GLY98 4.0 20.7 1.0
CA A:CYS100 4.2 20.5 1.0
N A:CYS103 4.2 16.9 1.0
C A:CYS111 4.3 17.1 1.0
C A:CYS97 4.4 20.5 1.0
CA A:CYS103 4.4 17.1 1.0
N A:LYS99 4.5 21.9 1.0
C A:GLN96 4.6 17.9 1.0
C A:CYS100 4.8 20.8 1.0
N A:LYS113 4.9 18.3 1.0
O A:HOH753 4.9 36.4 1.0
CA A:GLN96 4.9 17.4 1.0
O A:CYS100 4.9 20.3 1.0
CA A:GLY98 5.0 21.7 1.0

Zinc binding site 3 out of 4 in 1n92

Go back to Zinc Binding Sites List in 1n92
Zinc binding site 3 out of 4 in the Horse Liver Alcohol Dehydrogenase Complexed with Nad+ and 4- Iodopyrazole


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Horse Liver Alcohol Dehydrogenase Complexed with Nad+ and 4- Iodopyrazole within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn375

b:18.5
occ:1.00
 NE2 B:HIS67 2.0 13.3 1.0
SG B:CYS174 2.2 15.6 1.0
N1 B:PYZ378 2.2 16.0 1.0
SG B:CYS46 2.3 16.5 1.0
CD2 B:HIS67 3.0 15.5 1.0
CE1 B:HIS67 3.1 13.7 1.0
N2 B:PYZ378 3.2 16.6 1.0
C5 B:PYZ378 3.2 17.2 1.0
C5N B:NAJ377 3.2 11.9 1.0
CB B:CYS174 3.3 13.5 1.0
CB B:CYS46 3.3 15.5 1.0
C4N B:NAJ377 3.6 12.2 1.0
C6N B:NAJ377 4.0 12.0 1.0
OG B:SER48 4.2 14.9 1.0
CG B:HIS67 4.2 13.7 1.0
ND1 B:HIS67 4.2 13.7 1.0
CB B:SER48 4.2 14.9 1.0
C4 B:PYZ378 4.3 16.4 1.0
C3 B:PYZ378 4.4 18.6 1.0
NH2 B:ARG369 4.5 17.9 1.0
CE2 B:PHE93 4.6 14.8 1.0
CA B:CYS174 4.7 12.2 1.0
CZ B:PHE93 4.8 13.6 1.0
CA B:CYS46 4.8 16.4 1.0
OE2 B:GLU68 4.9 18.3 1.0
N B:SER48 5.0 14.5 1.0
C B:CYS174 5.0 13.0 1.0

Zinc binding site 4 out of 4 in 1n92

Go back to Zinc Binding Sites List in 1n92
Zinc binding site 4 out of 4 in the Horse Liver Alcohol Dehydrogenase Complexed with Nad+ and 4- Iodopyrazole


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Horse Liver Alcohol Dehydrogenase Complexed with Nad+ and 4- Iodopyrazole within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn376

b:16.7
occ:1.00
 SG B:CYS100 2.3 16.2 1.0
SG B:CYS103 2.3 14.9 1.0
SG B:CYS111 2.3 15.1 1.0
SG B:CYS97 2.3 17.3 1.0
CB B:CYS111 3.3 15.3 1.0
CB B:CYS100 3.4 16.4 1.0
CB B:CYS97 3.4 16.1 1.0
CB B:CYS103 3.5 15.8 1.0
N B:CYS97 3.5 14.3 1.0
CA B:CYS111 3.8 14.3 1.0
N B:CYS100 3.9 19.2 1.0
CA B:CYS97 3.9 15.7 1.0
N B:LEU112 4.0 15.0 1.0
N B:GLY98 4.0 17.5 1.0
N B:CYS103 4.2 15.5 1.0
CA B:CYS100 4.2 17.8 1.0
C B:CYS111 4.3 13.8 1.0
C B:CYS97 4.3 16.8 1.0
CA B:CYS103 4.4 15.3 1.0
N B:LYS99 4.5 18.8 1.0
C B:GLN96 4.6 15.2 1.0
C B:CYS100 4.8 17.1 1.0
N B:LYS113 4.9 15.4 1.0
CG B:LYS113 4.9 18.7 1.0
CA B:GLN96 4.9 14.0 1.0
O B:CYS100 4.9 17.2 1.0
O B:HOH464 5.0 31.7 1.0
CA B:GLY98 5.0 18.7 1.0

Reference:

J.K.Rubach, B.V.Plapp. Amino Acid Residues in the Nicotinamide Binding Site Contribute to Catalysis By Horse Liver Alcohol Dehydrogenase Biochemistry V. 42 2907 2003.
ISSN: ISSN 0006-2960
PubMed: 12627956
DOI: 10.1021/BI0272656
Page generated: Wed Oct 16 17:13:32 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy