Zinc in PDB 1mq0: Crystal Structure of Human Cytidine Deaminase

All present enzymatic activity of Crystal Structure of Human Cytidine Deaminase:
3.5.4.5;

The structure of Crystal Structure of Human Cytidine Deaminase, PDB code: 1mq0 was solved by S.J.Chung, J.C.Fromme, G.L.Verdine, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.45 / 2.40
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	52.398, 55.680, 90.689, 90.00, 90.00, 90.00
R / Rfree (%)	21.7 / 26.2

The binding sites of Zinc atom in the Crystal Structure of Human Cytidine Deaminase (pdb code 1mq0). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Human Cytidine Deaminase, PDB code: 1mq0:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of Human Cytidine Deaminase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human Cytidine Deaminase within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn147 b:43.0 occ:1.00 SG A:CYS102 2.4 31.6 1.0 SG A:CYS99 2.5 34.3 1.0 SG A:CYS65 2.5 32.6 1.0 CB A:CYS65 3.0 29.9 1.0 CB A:CYS102 3.2 30.4 1.0 CB A:CYS99 3.4 30.4 1.0 N A:CYS99 3.7 30.8 1.0 OE1 A:GLU67 3.7 29.3 1.0 N A:CYS102 4.0 30.3 1.0 NH1 A:ARG68 4.0 40.7 1.0 CA A:CYS99 4.1 29.9 1.0 SG B:CYS59 4.1 42.4 1.0 N3 A:BRD148 4.1 36.7 1.0 OE2 A:GLU67 4.2 33.4 1.0 CA A:CYS102 4.2 31.7 1.0 CD A:GLU67 4.2 28.8 1.0 C7 A:BRD148 4.2 37.3 1.0 O A:CYS99 4.4 28.2 1.0 C2 A:BRD148 4.4 35.0 1.0 CA A:CYS65 4.5 28.9 1.0 C A:CYS99 4.6 29.2 1.0 C4 A:BRD148 4.6 38.8 1.0 N1 A:BRD148 4.7 37.1 1.0 CG A:ARG68 4.8 35.9 1.0 C A:PRO98 4.8 31.2 1.0 O2 A:BRD148 4.9 34.8 1.0 CD A:ARG68 5.0 35.3 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of Human Cytidine Deaminase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Human Cytidine Deaminase within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn147 b:41.7 occ:1.00 SG B:CYS99 2.3 30.3 1.0 O B:HOH151 2.4 30.8 1.0 SG B:CYS102 2.4 30.5 1.0 SG B:CYS65 2.5 25.9 1.0 CB B:CYS65 3.2 26.0 1.0 CB B:CYS102 3.2 26.7 1.0 CB B:CYS99 3.4 29.6 1.0 N B:CYS99 3.7 28.9 1.0 N B:CYS102 3.8 26.8 1.0 SG A:CYS59 3.9 37.1 1.0 OE2 B:GLU67 4.0 29.9 1.0 NH2 B:ARG68 4.0 27.9 1.0 CA B:CYS99 4.1 29.9 1.0 CA B:CYS102 4.1 26.6 1.0 NE B:ARG68 4.2 28.2 1.0 C7 B:BRD149 4.3 29.0 1.0 O B:CYS99 4.4 30.2 1.0 N3 B:BRD149 4.4 30.4 1.0 CD B:GLU67 4.5 30.1 1.0 C B:CYS99 4.5 29.4 1.0 OE1 B:GLU67 4.5 29.3 1.0 C2 B:BRD149 4.6 32.2 1.0 CZ B:ARG68 4.6 29.0 1.0 CA B:CYS65 4.7 26.4 1.0 N1 B:BRD149 4.8 31.4 1.0 CB B:ALA101 4.8 20.8 1.0 C B:PRO98 4.9 29.4 1.0 C B:ALA101 4.9 26.0 1.0

S.J.Chung, J.C.Fromme, G.L.Verdine. Structure of Human Cytidine Deaminase Bound to A Potent Inhibitor J.Med.Chem. V. 48 658 2005.
ISSN: ISSN 0022-2623
PubMed: 15689149
DOI: 10.1021/JM0496279