Zinc in PDB 1mnc: Structure of Human Neutrophil Collagenase Reveals Large S1' Specificity Pocket

All present enzymatic activity of Structure of Human Neutrophil Collagenase Reveals Large S1' Specificity Pocket:
3.4.24.7;

The structure of Structure of Human Neutrophil Collagenase Reveals Large S1' Specificity Pocket, PDB code: 1mnc was solved by T.Stams, J.C.Spurlino, D.L.Smith, B.Rubin, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	8.00 / 2.10
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	34.920, 61.280, 68.250, 90.00, 90.00, 90.00
R / Rfree (%)	n/a / n/a

The structure of Structure of Human Neutrophil Collagenase Reveals Large S1' Specificity Pocket also contains other interesting chemical elements:

Calcium

(Ca)

1 atom

The binding sites of Zinc atom in the Structure of Human Neutrophil Collagenase Reveals Large S1' Specificity Pocket (pdb code 1mnc). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of Human Neutrophil Collagenase Reveals Large S1' Specificity Pocket, PDB code: 1mnc:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Structure of Human Neutrophil Collagenase Reveals Large S1' Specificity Pocket


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Human Neutrophil Collagenase Reveals Large S1' Specificity Pocket within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn281 b:10.1 occ:1.00 NE2 A:HIS218 2.0 0.5 1.0 NE2 A:HIS222 2.0 6.8 1.0 NE2 A:HIS228 2.1 5.2 1.0 O2 A:PLH280 2.1 9.0 1.0 O1 A:PLH280 2.3 9.5 1.0 C1 A:PLH280 2.8 8.3 1.0 N1 A:PLH280 2.8 8.1 1.0 CE1 A:HIS222 3.0 9.9 1.0 CE1 A:HIS228 3.0 3.9 1.0 CD2 A:HIS218 3.0 1.1 1.0 CE1 A:HIS218 3.1 3.0 1.0 CD2 A:HIS228 3.1 3.3 1.0 CD2 A:HIS222 3.1 3.8 1.0 O A:HOH58 4.0 10.9 1.0 ND1 A:HIS228 4.1 5.5 1.0 ND1 A:HIS222 4.1 12.1 1.0 CG A:HIS218 4.2 0.5 1.0 ND1 A:HIS218 4.2 0.5 1.0 C2 A:PLH280 4.2 7.6 1.0 CG A:HIS228 4.2 6.4 1.0 CG A:HIS222 4.2 9.3 1.0 OE1 A:GLU219 4.3 5.2 1.0 C3 A:PLH280 4.6 9.2 1.0 C4 A:PLH280 4.7 10.1 1.0 OE2 A:GLU219 4.7 3.8 1.0 CE A:MET236 4.9 5.8 1.0 CD A:GLU219 4.9 2.5 1.0

Zinc binding site 2 out of 2 in the Structure of Human Neutrophil Collagenase Reveals Large S1' Specificity Pocket


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of Human Neutrophil Collagenase Reveals Large S1' Specificity Pocket within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn282 b:11.2 occ:1.00 NE2 A:HIS183 1.8 5.2 1.0 NE2 A:HIS168 1.9 1.8 1.0 OD2 A:ASP170 1.9 12.4 1.0 ND1 A:HIS196 2.0 4.0 1.0 CD2 A:HIS168 2.7 1.0 1.0 CE1 A:HIS183 2.8 6.7 1.0 CE1 A:HIS196 2.9 4.3 1.0 CG A:ASP170 2.9 10.2 1.0 CD2 A:HIS183 2.9 5.7 1.0 CE1 A:HIS168 3.0 0.5 1.0 CG A:HIS196 3.0 2.3 1.0 OD1 A:ASP170 3.2 10.7 1.0 CB A:HIS196 3.5 2.0 1.0 CG A:HIS168 3.9 4.4 1.0 ND1 A:HIS183 4.0 6.7 1.0 NE2 A:HIS196 4.0 9.2 1.0 CG A:HIS183 4.0 1.1 1.0 ND1 A:HIS168 4.1 1.5 1.0 CD2 A:HIS196 4.1 5.6 1.0 CZ A:PHE185 4.2 13.1 1.0 O A:SER172 4.3 10.8 1.0 CB A:ASP170 4.3 12.5 1.0 CE2 A:PHE185 4.5 13.3 1.0 CE2 A:PHE174 4.6 2.3 1.0 CZ A:PHE174 4.7 2.8 1.0 O A:HOH21 4.9 21.7 1.0

T.Stams, J.C.Spurlino, D.L.Smith, R.C.Wahl, T.F.Ho, M.W.Qoronfleh, T.M.Banks, B.Rubin. Structure of Human Neutrophil Collagenase Reveals Large S1' Specificity Pocket. Nat.Struct.Biol. V. 1 119 1994.
ISSN: ISSN 1072-8368
PubMed: 7656015
DOI: 10.1038/NSB0294-119