Zinc in PDB 1mm7: Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with Quisqualate in A Zinc Crystal Form at 1.65 Angstroms Resolution

The structure of Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with Quisqualate in A Zinc Crystal Form at 1.65 Angstroms Resolution, PDB code: 1mm7 was solved by R.Jin, M.Horning, M.L.Mayer, E.Gouaux, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.85 / 1.65
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	113.912, 163.453, 47.336, 90.00, 90.00, 90.00
R / Rfree (%)	20.4 / 23.7

The binding sites of Zinc atom in the Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with Quisqualate in A Zinc Crystal Form at 1.65 Angstroms Resolution (pdb code 1mm7). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 5 binding sites of Zinc where determined in the Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with Quisqualate in A Zinc Crystal Form at 1.65 Angstroms Resolution, PDB code: 1mm7:
Jump to Zinc binding site number: 1; 2; 3; 4; 5;

Zinc binding site 1 out of 5 in the Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with Quisqualate in A Zinc Crystal Form at 1.65 Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with Quisqualate in A Zinc Crystal Form at 1.65 Angstroms Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn901 b:18.1 occ:1.00 OE2 B:GLU166 1.9 14.3 1.0 OE1 A:GLU42 1.9 16.9 1.0 NE2 A:HIS46 2.1 13.0 1.0 O A:HOH923 2.2 16.6 1.0 CD B:GLU166 2.6 15.7 1.0 OE1 B:GLU166 2.7 16.8 1.0 CD A:GLU42 2.9 14.8 1.0 CD2 A:HIS46 3.0 13.0 1.0 CE1 A:HIS46 3.1 14.7 1.0 OE2 A:GLU42 3.2 14.4 1.0 CD2 A:LEU241 4.0 10.4 1.0 CG B:GLU166 4.1 15.7 1.0 ND1 A:HIS46 4.2 14.7 1.0 CG A:HIS46 4.2 13.1 1.0 CG A:GLU42 4.2 11.8 1.0 N B:SER168 4.3 14.2 1.0 O B:ALA165 4.6 13.0 1.0 CB A:GLU42 4.7 10.1 1.0 CB B:GLU166 4.7 14.0 1.0 CB B:SER168 4.8 13.1 1.0 O B:HOH1142 4.9 31.7 1.0 CA B:GLU166 4.9 14.7 1.0 CA B:SER168 4.9 12.7 1.0 CA B:PRO167 5.0 12.4 1.0 C B:PRO167 5.0 14.2 1.0 CD2 A:LEU246 5.0 17.9 1.0

Zinc binding site 2 out of 5 in the Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with Quisqualate in A Zinc Crystal Form at 1.65 Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with Quisqualate in A Zinc Crystal Form at 1.65 Angstroms Resolution within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn902 b:25.0 occ:1.00 NE2 B:HIS23 2.0 17.5 1.0 OE2 B:GLU30 2.0 28.4 1.0 O B:HOH1082 2.5 24.4 1.0 CD B:GLU30 2.8 23.1 1.0 CE1 B:HIS23 2.9 17.1 1.0 CD2 B:HIS23 3.0 17.5 1.0 OE1 B:GLU30 3.0 20.3 1.0 CD B:LYS20 4.0 17.5 1.0 ND1 B:HIS23 4.0 18.6 1.0 NZ B:LYS20 4.1 18.0 1.0 CG B:HIS23 4.1 19.4 1.0 CG B:GLU30 4.3 22.7 1.0 O B:GLU30 4.4 19.5 1.0 CD1 B:LEU26 4.6 32.4 1.0 CE B:LYS20 4.7 16.0 1.0

Zinc binding site 3 out of 5 in the Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with Quisqualate in A Zinc Crystal Form at 1.65 Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with Quisqualate in A Zinc Crystal Form at 1.65 Angstroms Resolution within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn904 b:17.4 occ:1.00 OE1 B:GLU42 2.0 16.6 1.0 NE2 B:HIS46 2.0 13.1 1.0 O B:HOH1036 2.1 15.2 1.0 CD B:GLU42 2.9 16.5 1.0 CE1 B:HIS46 2.9 14.6 1.0 CD2 B:HIS46 3.0 14.0 1.0 OE2 B:GLU42 3.2 19.5 1.0 NZ B:LYS45 3.5 24.1 1.0 CD2 B:LEU241 3.6 14.0 1.0 CE B:LYS45 3.6 21.5 1.0 OE1 B:GLN244 3.7 32.1 1.0 ND1 B:HIS46 4.1 15.5 1.0 O B:HOH1057 4.1 27.7 1.0 O B:HOH1084 4.1 26.5 1.0 CG B:HIS46 4.2 12.9 1.0 CG B:GLU42 4.3 12.2 1.0 CB B:GLU42 4.6 9.9 1.0 CD B:GLN244 4.7 32.6 1.0 CG B:LEU246 4.9 17.5 1.0

Zinc binding site 4 out of 5 in the Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with Quisqualate in A Zinc Crystal Form at 1.65 Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with Quisqualate in A Zinc Crystal Form at 1.65 Angstroms Resolution within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn903 b:23.3 occ:1.00 OD2 C:ASP65 2.1 18.5 1.0 O C:HOH1052 2.2 30.5 1.0 CG C:ASP65 2.8 19.8 1.0 OD1 C:ASP65 2.8 19.8 1.0 OD2 C:ASP67 4.0 43.4 1.0 CB C:ASP67 4.2 34.0 1.0 CB C:ASP65 4.2 18.0 1.0 O C:HOH1068 4.6 39.1 1.0 CG C:ASP67 4.6 40.4 1.0 N C:ASP67 5.0 28.6 1.0

Zinc binding site 5 out of 5 in the Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with Quisqualate in A Zinc Crystal Form at 1.65 Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with Quisqualate in A Zinc Crystal Form at 1.65 Angstroms Resolution within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn905 b:46.5 occ:1.00 OE1 C:GLU42 2.3 28.3 1.0 O C:HOH1030 2.8 39.3 1.0 NE2 C:HIS46 2.8 32.2 1.0 CD2 C:HIS46 3.2 29.3 1.0 CD C:GLU42 3.4 29.5 1.0 OE1 C:GLN244 3.7 34.5 1.0 CD2 C:LEU241 3.9 16.6 1.0 OE2 C:GLU42 3.9 34.1 1.0 CE1 C:HIS46 4.0 31.8 1.0 CD C:GLN244 4.5 33.6 1.0 NE2 C:GLN244 4.5 33.7 1.0 CG C:HIS46 4.6 28.0 1.0 CG C:GLU42 4.7 26.5 1.0 CB C:GLU42 4.8 21.1 1.0 ND1 C:HIS46 4.9 31.1 1.0

R.Jin, M.Horning, M.L.Mayer, E.Gouaux. Mechanism of Activation and Selectivity in A Ligand-Gated Ion Channel: Structural and Functional Studies of GLUR2 and Quisqualate Biochemistry V. 41 15635 2003.
ISSN: ISSN 0006-2960
PubMed: 12501192
DOI: 10.1021/BI020583K