Zinc in PDB 1mkd: Crystal Structure of PDE4D Catalytic Domain and Zardaverine Complex
Enzymatic activity of Crystal Structure of PDE4D Catalytic Domain and Zardaverine Complex
All present enzymatic activity of Crystal Structure of PDE4D Catalytic Domain and Zardaverine Complex:
3.1.4.17;
Protein crystallography data
The structure of Crystal Structure of PDE4D Catalytic Domain and Zardaverine Complex, PDB code: 1mkd
was solved by
M.E.Lee,
J.Markowitz,
J.-O.Lee,
H.Lee,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Resolution Low / High (Å)
|
19.98 /
2.90
|
Space group
|
P 21 21 21
|
Cell size a, b, c (Å), α, β, γ (°)
|
97.325,
164.572,
325.540,
90.00,
90.00,
90.00
|
R / Rfree (%)
|
24.5 /
26
|
Other elements in 1mkd:
The structure of Crystal Structure of PDE4D Catalytic Domain and Zardaverine Complex also contains other interesting chemical elements:
Zinc Binding Sites:
Pages:
>>> Page 1 <<<
Page 2, Binding sites: 11 -
12;
Binding sites:
The binding sites of Zinc atom in the Crystal Structure of PDE4D Catalytic Domain and Zardaverine Complex
(pdb code 1mkd). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 12 binding sites of Zinc where determined in the
Crystal Structure of PDE4D Catalytic Domain and Zardaverine Complex, PDB code: 1mkd:
Jump to Zinc binding site number:
1;
2;
3;
4;
5;
6;
7;
8;
9;
10;
Zinc binding site 1 out
of 12 in 1mkd
Go back to
Zinc Binding Sites List in 1mkd
Zinc binding site 1 out
of 12 in the Crystal Structure of PDE4D Catalytic Domain and Zardaverine Complex
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Crystal Structure of PDE4D Catalytic Domain and Zardaverine Complex within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Zn2001
b:30.6
occ:1.00
|
OD2
|
A:ASP298
|
2.1
|
34.6
|
1.0
|
OD1
|
A:ASP415
|
2.2
|
34.5
|
1.0
|
NE2
|
A:HIS297
|
2.3
|
26.2
|
1.0
|
NE2
|
A:HIS261
|
2.4
|
33.0
|
1.0
|
CG
|
A:ASP415
|
3.0
|
33.2
|
1.0
|
OD2
|
A:ASP415
|
3.0
|
33.9
|
1.0
|
O
|
A:HOH1001
|
3.1
|
1.1
|
1.0
|
CD2
|
A:HIS297
|
3.2
|
28.1
|
1.0
|
CG
|
A:ASP298
|
3.2
|
32.3
|
1.0
|
CD2
|
A:HIS261
|
3.3
|
32.6
|
1.0
|
CE1
|
A:HIS261
|
3.3
|
31.9
|
1.0
|
CE1
|
A:HIS297
|
3.4
|
26.1
|
1.0
|
OD1
|
A:ASP298
|
3.7
|
36.9
|
1.0
|
MG
|
A:MG2002
|
4.0
|
21.8
|
1.0
|
CD2
|
A:HIS257
|
4.1
|
32.2
|
1.0
|
CG
|
A:HIS297
|
4.4
|
27.1
|
1.0
|
CB
|
A:ASP415
|
4.4
|
31.8
|
1.0
|
CB
|
A:ASP298
|
4.4
|
29.5
|
1.0
|
ND1
|
A:HIS261
|
4.5
|
31.1
|
1.0
|
ND1
|
A:HIS297
|
4.5
|
26.0
|
1.0
|
CG
|
A:HIS261
|
4.5
|
31.2
|
1.0
|
NE2
|
A:HIS257
|
4.5
|
32.2
|
1.0
|
O
|
A:ASP415
|
4.9
|
33.0
|
1.0
|
CG2
|
A:VAL265
|
5.0
|
27.7
|
1.0
|
|
Zinc binding site 2 out
of 12 in 1mkd
Go back to
Zinc Binding Sites List in 1mkd
Zinc binding site 2 out
of 12 in the Crystal Structure of PDE4D Catalytic Domain and Zardaverine Complex
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 2 of Crystal Structure of PDE4D Catalytic Domain and Zardaverine Complex within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Zn2003
b:31.5
occ:1.00
|
OD1
|
B:ASP415
|
2.1
|
36.0
|
1.0
|
OD2
|
B:ASP298
|
2.2
|
33.5
|
1.0
|
NE2
|
B:HIS297
|
2.3
|
19.1
|
1.0
|
NE2
|
B:HIS261
|
2.3
|
26.9
|
1.0
|
CG
|
B:ASP415
|
2.9
|
32.4
|
1.0
|
OD2
|
B:ASP415
|
3.0
|
33.9
|
1.0
|
O
|
B:HOH1002
|
3.1
|
1.1
|
1.0
|
CD2
|
B:HIS297
|
3.2
|
22.7
|
1.0
|
CE1
|
B:HIS261
|
3.3
|
27.7
|
1.0
|
CD2
|
B:HIS261
|
3.3
|
30.4
|
1.0
|
CG
|
B:ASP298
|
3.3
|
31.1
|
1.0
|
CE1
|
B:HIS297
|
3.3
|
22.6
|
1.0
|
MG
|
B:MG2004
|
3.5
|
21.8
|
1.0
|
OD1
|
B:ASP298
|
3.8
|
34.9
|
1.0
|
CD2
|
B:HIS257
|
4.2
|
31.4
|
1.0
|
CB
|
B:ASP415
|
4.4
|
31.1
|
1.0
|
CG
|
B:HIS297
|
4.4
|
23.0
|
1.0
|
ND1
|
B:HIS261
|
4.4
|
28.1
|
1.0
|
ND1
|
B:HIS297
|
4.4
|
22.3
|
1.0
|
CG
|
B:HIS261
|
4.4
|
30.2
|
1.0
|
CB
|
B:ASP298
|
4.5
|
29.3
|
1.0
|
NE2
|
B:HIS257
|
4.6
|
31.9
|
1.0
|
O
|
B:ASP415
|
4.8
|
30.0
|
1.0
|
CG2
|
B:VAL265
|
4.9
|
26.1
|
1.0
|
CA
|
B:ASP415
|
4.9
|
30.7
|
1.0
|
|
Zinc binding site 3 out
of 12 in 1mkd
Go back to
Zinc Binding Sites List in 1mkd
Zinc binding site 3 out
of 12 in the Crystal Structure of PDE4D Catalytic Domain and Zardaverine Complex
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 3 of Crystal Structure of PDE4D Catalytic Domain and Zardaverine Complex within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:Zn2005
b:39.4
occ:1.00
|
OD2
|
C:ASP298
|
2.0
|
35.3
|
1.0
|
OD1
|
C:ASP415
|
2.2
|
30.7
|
1.0
|
NE2
|
C:HIS297
|
2.2
|
26.8
|
1.0
|
NE2
|
C:HIS261
|
2.4
|
30.3
|
1.0
|
CG
|
C:ASP415
|
2.9
|
29.6
|
1.0
|
OD2
|
C:ASP415
|
3.0
|
31.5
|
1.0
|
CD2
|
C:HIS297
|
3.0
|
26.0
|
1.0
|
CG
|
C:ASP298
|
3.2
|
34.2
|
1.0
|
CE1
|
C:HIS297
|
3.3
|
27.3
|
1.0
|
O
|
C:HOH1003
|
3.4
|
1.1
|
1.0
|
CD2
|
C:HIS261
|
3.4
|
30.5
|
1.0
|
CE1
|
C:HIS261
|
3.4
|
30.7
|
1.0
|
OD1
|
C:ASP298
|
3.7
|
35.5
|
1.0
|
MG
|
C:MG2006
|
3.9
|
16.5
|
1.0
|
CD2
|
C:HIS257
|
4.2
|
33.3
|
1.0
|
CG
|
C:HIS297
|
4.3
|
25.7
|
1.0
|
ND1
|
C:HIS297
|
4.4
|
26.9
|
1.0
|
CB
|
C:ASP298
|
4.4
|
32.4
|
1.0
|
CB
|
C:ASP415
|
4.4
|
29.3
|
1.0
|
ND1
|
C:HIS261
|
4.5
|
29.7
|
1.0
|
CG
|
C:HIS261
|
4.5
|
30.4
|
1.0
|
NE2
|
C:HIS257
|
4.6
|
32.4
|
1.0
|
O
|
C:ASP415
|
5.0
|
32.2
|
1.0
|
CG2
|
C:VAL265
|
5.0
|
29.0
|
1.0
|
|
Zinc binding site 4 out
of 12 in 1mkd
Go back to
Zinc Binding Sites List in 1mkd
Zinc binding site 4 out
of 12 in the Crystal Structure of PDE4D Catalytic Domain and Zardaverine Complex
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 4 of Crystal Structure of PDE4D Catalytic Domain and Zardaverine Complex within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:Zn2007
b:38.3
occ:1.00
|
OD2
|
D:ASP298
|
2.1
|
36.5
|
1.0
|
OD1
|
D:ASP415
|
2.2
|
33.5
|
1.0
|
NE2
|
D:HIS297
|
2.3
|
26.3
|
1.0
|
NE2
|
D:HIS261
|
2.4
|
33.6
|
1.0
|
CG
|
D:ASP415
|
2.9
|
32.9
|
1.0
|
OD2
|
D:ASP415
|
3.0
|
34.0
|
1.0
|
CD2
|
D:HIS297
|
3.2
|
27.5
|
1.0
|
O
|
D:HOH1004
|
3.2
|
1.1
|
1.0
|
CG
|
D:ASP298
|
3.2
|
35.0
|
1.0
|
CE1
|
D:HIS261
|
3.3
|
34.8
|
1.0
|
CD2
|
D:HIS261
|
3.3
|
34.7
|
1.0
|
CE1
|
D:HIS297
|
3.4
|
28.9
|
1.0
|
MG
|
D:MG2008
|
3.7
|
13.9
|
1.0
|
OD1
|
D:ASP298
|
3.8
|
37.0
|
1.0
|
CD2
|
D:HIS257
|
4.1
|
34.1
|
1.0
|
CG
|
D:HIS297
|
4.4
|
28.3
|
1.0
|
CB
|
D:ASP415
|
4.4
|
31.6
|
1.0
|
ND1
|
D:HIS261
|
4.4
|
34.2
|
1.0
|
ND1
|
D:HIS297
|
4.4
|
28.1
|
1.0
|
CB
|
D:ASP298
|
4.4
|
32.2
|
1.0
|
CG
|
D:HIS261
|
4.4
|
34.1
|
1.0
|
NE2
|
D:HIS257
|
4.5
|
33.1
|
1.0
|
O
|
D:ASP415
|
4.8
|
29.7
|
1.0
|
CG2
|
D:VAL265
|
4.9
|
29.9
|
1.0
|
|
Zinc binding site 5 out
of 12 in 1mkd
Go back to
Zinc Binding Sites List in 1mkd
Zinc binding site 5 out
of 12 in the Crystal Structure of PDE4D Catalytic Domain and Zardaverine Complex
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 5 of Crystal Structure of PDE4D Catalytic Domain and Zardaverine Complex within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
E:Zn2009
b:39.1
occ:1.00
|
OD2
|
E:ASP298
|
2.0
|
34.0
|
1.0
|
NE2
|
E:HIS297
|
2.1
|
24.0
|
1.0
|
NE2
|
E:HIS261
|
2.3
|
32.2
|
1.0
|
OD1
|
E:ASP415
|
2.3
|
29.8
|
1.0
|
CD2
|
E:HIS297
|
3.0
|
25.0
|
1.0
|
CG
|
E:ASP415
|
3.1
|
28.0
|
1.0
|
CG
|
E:ASP298
|
3.1
|
31.8
|
1.0
|
OD2
|
E:ASP415
|
3.2
|
29.3
|
1.0
|
CD2
|
E:HIS261
|
3.2
|
32.9
|
1.0
|
CE1
|
E:HIS297
|
3.2
|
25.6
|
1.0
|
CE1
|
E:HIS261
|
3.3
|
33.7
|
1.0
|
O
|
E:HOH1005
|
3.3
|
1.1
|
1.0
|
OD1
|
E:ASP298
|
3.7
|
33.3
|
1.0
|
MG
|
E:MG2010
|
4.1
|
31.0
|
1.0
|
CD2
|
E:HIS257
|
4.1
|
33.8
|
1.0
|
CG
|
E:HIS297
|
4.2
|
24.8
|
1.0
|
ND1
|
E:HIS297
|
4.3
|
25.6
|
1.0
|
CB
|
E:ASP298
|
4.3
|
30.1
|
1.0
|
CG
|
E:HIS261
|
4.3
|
33.7
|
1.0
|
ND1
|
E:HIS261
|
4.4
|
33.7
|
1.0
|
CB
|
E:ASP415
|
4.5
|
27.3
|
1.0
|
NE2
|
E:HIS257
|
4.6
|
35.6
|
1.0
|
CG2
|
E:VAL265
|
4.9
|
27.7
|
1.0
|
O
|
E:ASP415
|
5.0
|
28.7
|
1.0
|
|
Zinc binding site 6 out
of 12 in 1mkd
Go back to
Zinc Binding Sites List in 1mkd
Zinc binding site 6 out
of 12 in the Crystal Structure of PDE4D Catalytic Domain and Zardaverine Complex
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 6 of Crystal Structure of PDE4D Catalytic Domain and Zardaverine Complex within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
F:Zn2011
b:41.7
occ:1.00
|
OD2
|
F:ASP298
|
2.0
|
31.2
|
1.0
|
OD1
|
F:ASP415
|
2.2
|
34.5
|
1.0
|
NE2
|
F:HIS297
|
2.3
|
27.4
|
1.0
|
NE2
|
F:HIS261
|
2.4
|
32.0
|
1.0
|
CG
|
F:ASP415
|
3.0
|
31.5
|
1.0
|
OD2
|
F:ASP415
|
3.1
|
33.5
|
1.0
|
CD2
|
F:HIS297
|
3.1
|
27.6
|
1.0
|
CG
|
F:ASP298
|
3.2
|
31.0
|
1.0
|
O
|
F:HOH1006
|
3.3
|
1.1
|
1.0
|
CD2
|
F:HIS261
|
3.3
|
32.5
|
1.0
|
CE1
|
F:HIS261
|
3.4
|
33.7
|
1.0
|
CE1
|
F:HIS297
|
3.4
|
28.2
|
1.0
|
OD1
|
F:ASP298
|
3.7
|
34.6
|
1.0
|
MG
|
F:MG2012
|
3.8
|
25.9
|
1.0
|
CD2
|
F:HIS257
|
4.1
|
32.8
|
1.0
|
CG
|
F:HIS297
|
4.3
|
26.8
|
1.0
|
CB
|
F:ASP298
|
4.4
|
30.6
|
1.0
|
ND1
|
F:HIS297
|
4.4
|
27.1
|
1.0
|
CB
|
F:ASP415
|
4.4
|
29.9
|
1.0
|
ND1
|
F:HIS261
|
4.5
|
32.5
|
1.0
|
CG
|
F:HIS261
|
4.5
|
32.4
|
1.0
|
NE2
|
F:HIS257
|
4.5
|
32.2
|
1.0
|
O
|
F:ASP415
|
5.0
|
31.6
|
1.0
|
CG2
|
F:VAL265
|
5.0
|
29.1
|
1.0
|
|
Zinc binding site 7 out
of 12 in 1mkd
Go back to
Zinc Binding Sites List in 1mkd
Zinc binding site 7 out
of 12 in the Crystal Structure of PDE4D Catalytic Domain and Zardaverine Complex
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 7 of Crystal Structure of PDE4D Catalytic Domain and Zardaverine Complex within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
G:Zn2013
b:36.8
occ:1.00
|
OD2
|
G:ASP298
|
2.0
|
35.4
|
1.0
|
OD1
|
G:ASP415
|
2.3
|
33.5
|
1.0
|
NE2
|
G:HIS261
|
2.3
|
31.4
|
1.0
|
NE2
|
G:HIS297
|
2.3
|
28.6
|
1.0
|
CG
|
G:ASP415
|
3.0
|
33.1
|
1.0
|
OD2
|
G:ASP415
|
3.1
|
35.7
|
1.0
|
CD2
|
G:HIS297
|
3.2
|
30.0
|
1.0
|
CG
|
G:ASP298
|
3.2
|
33.4
|
1.0
|
CD2
|
G:HIS261
|
3.2
|
32.1
|
1.0
|
CE1
|
G:HIS261
|
3.3
|
32.1
|
1.0
|
O
|
G:HOH1007
|
3.4
|
1.1
|
1.0
|
CE1
|
G:HIS297
|
3.4
|
29.3
|
1.0
|
OD1
|
G:ASP298
|
3.8
|
35.0
|
1.0
|
MG
|
G:MG2014
|
3.8
|
17.7
|
1.0
|
CD2
|
G:HIS257
|
4.1
|
33.2
|
1.0
|
CG
|
G:HIS297
|
4.4
|
29.3
|
1.0
|
CB
|
G:ASP298
|
4.4
|
31.2
|
1.0
|
ND1
|
G:HIS261
|
4.4
|
31.1
|
1.0
|
CG
|
G:HIS261
|
4.4
|
32.7
|
1.0
|
ND1
|
G:HIS297
|
4.4
|
28.8
|
1.0
|
CB
|
G:ASP415
|
4.5
|
31.5
|
1.0
|
NE2
|
G:HIS257
|
4.5
|
33.5
|
1.0
|
O
|
G:ASP415
|
4.9
|
34.0
|
1.0
|
CG2
|
G:VAL265
|
4.9
|
31.0
|
1.0
|
|
Zinc binding site 8 out
of 12 in 1mkd
Go back to
Zinc Binding Sites List in 1mkd
Zinc binding site 8 out
of 12 in the Crystal Structure of PDE4D Catalytic Domain and Zardaverine Complex
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 8 of Crystal Structure of PDE4D Catalytic Domain and Zardaverine Complex within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
H:Zn2015
b:33.5
occ:1.00
|
OD2
|
H:ASP298
|
2.0
|
30.2
|
1.0
|
OD1
|
H:ASP415
|
2.2
|
32.7
|
1.0
|
NE2
|
H:HIS297
|
2.3
|
27.9
|
1.0
|
NE2
|
H:HIS261
|
2.3
|
31.9
|
1.0
|
CG
|
H:ASP415
|
3.0
|
30.5
|
1.0
|
OD2
|
H:ASP415
|
3.1
|
32.0
|
1.0
|
CD2
|
H:HIS297
|
3.1
|
27.7
|
1.0
|
CG
|
H:ASP298
|
3.2
|
30.2
|
1.0
|
CD2
|
H:HIS261
|
3.3
|
31.1
|
1.0
|
O
|
H:HOH1008
|
3.3
|
1.1
|
1.0
|
CE1
|
H:HIS261
|
3.3
|
31.2
|
1.0
|
CE1
|
H:HIS297
|
3.3
|
27.8
|
1.0
|
OD1
|
H:ASP298
|
3.7
|
31.9
|
1.0
|
MG
|
H:MG2016
|
3.8
|
32.2
|
1.0
|
CD2
|
H:HIS257
|
4.1
|
35.0
|
1.0
|
CG
|
H:HIS297
|
4.3
|
26.9
|
1.0
|
CB
|
H:ASP298
|
4.4
|
30.4
|
1.0
|
ND1
|
H:HIS297
|
4.4
|
27.5
|
1.0
|
ND1
|
H:HIS261
|
4.4
|
31.1
|
1.0
|
CG
|
H:HIS261
|
4.4
|
31.4
|
1.0
|
CB
|
H:ASP415
|
4.4
|
29.7
|
1.0
|
NE2
|
H:HIS257
|
4.5
|
36.4
|
1.0
|
O
|
H:ASP415
|
4.9
|
30.0
|
1.0
|
CG2
|
H:VAL265
|
4.9
|
29.7
|
1.0
|
|
Zinc binding site 9 out
of 12 in 1mkd
Go back to
Zinc Binding Sites List in 1mkd
Zinc binding site 9 out
of 12 in the Crystal Structure of PDE4D Catalytic Domain and Zardaverine Complex
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 9 of Crystal Structure of PDE4D Catalytic Domain and Zardaverine Complex within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
I:Zn2017
b:36.7
occ:1.00
|
OD2
|
I:ASP298
|
2.1
|
35.9
|
1.0
|
OD1
|
I:ASP415
|
2.1
|
31.8
|
1.0
|
NE2
|
I:HIS297
|
2.2
|
27.5
|
1.0
|
NE2
|
I:HIS261
|
2.3
|
32.4
|
1.0
|
CG
|
I:ASP415
|
2.9
|
32.7
|
1.0
|
OD2
|
I:ASP415
|
3.0
|
34.9
|
1.0
|
CD2
|
I:HIS297
|
3.0
|
27.8
|
1.0
|
CG
|
I:ASP298
|
3.2
|
34.6
|
1.0
|
CE1
|
I:HIS297
|
3.2
|
27.3
|
1.0
|
CD2
|
I:HIS261
|
3.3
|
33.8
|
1.0
|
CE1
|
I:HIS261
|
3.3
|
33.2
|
1.0
|
O
|
I:HOH1009
|
3.4
|
1.1
|
1.0
|
OD1
|
I:ASP298
|
3.8
|
38.0
|
1.0
|
MG
|
I:MG2018
|
4.0
|
21.8
|
1.0
|
CG
|
I:HIS297
|
4.2
|
25.2
|
1.0
|
CD2
|
I:HIS257
|
4.2
|
35.3
|
1.0
|
ND1
|
I:HIS297
|
4.3
|
26.4
|
1.0
|
CB
|
I:ASP415
|
4.3
|
32.1
|
1.0
|
CB
|
I:ASP298
|
4.4
|
32.1
|
1.0
|
ND1
|
I:HIS261
|
4.4
|
33.1
|
1.0
|
CG
|
I:HIS261
|
4.4
|
33.9
|
1.0
|
NE2
|
I:HIS257
|
4.7
|
35.4
|
1.0
|
O
|
I:ASP415
|
4.8
|
34.5
|
1.0
|
CG2
|
I:VAL265
|
4.8
|
30.2
|
1.0
|
CA
|
I:ASP415
|
5.0
|
32.0
|
1.0
|
|
Zinc binding site 10 out
of 12 in 1mkd
Go back to
Zinc Binding Sites List in 1mkd
Zinc binding site 10 out
of 12 in the Crystal Structure of PDE4D Catalytic Domain and Zardaverine Complex
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 10 of Crystal Structure of PDE4D Catalytic Domain and Zardaverine Complex within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
J:Zn2019
b:27.7
occ:1.00
|
OD2
|
J:ASP298
|
2.0
|
29.9
|
1.0
|
NE2
|
J:HIS261
|
2.2
|
34.1
|
1.0
|
NE2
|
J:HIS297
|
2.2
|
21.5
|
1.0
|
OD1
|
J:ASP415
|
2.2
|
33.4
|
1.0
|
CG
|
J:ASP415
|
3.1
|
31.1
|
1.0
|
CD2
|
J:HIS297
|
3.1
|
24.2
|
1.0
|
CD2
|
J:HIS261
|
3.1
|
34.0
|
1.0
|
CG
|
J:ASP298
|
3.1
|
28.8
|
1.0
|
OD2
|
J:ASP415
|
3.2
|
32.4
|
1.0
|
CE1
|
J:HIS261
|
3.2
|
33.9
|
1.0
|
O
|
J:HOH1010
|
3.2
|
1.1
|
1.0
|
CE1
|
J:HIS297
|
3.3
|
22.5
|
1.0
|
MG
|
J:MG2020
|
3.7
|
11.0
|
1.0
|
OD1
|
J:ASP298
|
3.7
|
32.5
|
1.0
|
CD2
|
J:HIS257
|
4.1
|
32.8
|
1.0
|
CB
|
J:ASP298
|
4.3
|
28.0
|
1.0
|
CG
|
J:HIS297
|
4.3
|
22.8
|
1.0
|
CG
|
J:HIS261
|
4.3
|
33.8
|
1.0
|
ND1
|
J:HIS261
|
4.3
|
34.2
|
1.0
|
ND1
|
J:HIS297
|
4.3
|
21.8
|
1.0
|
CB
|
J:ASP415
|
4.5
|
29.9
|
1.0
|
NE2
|
J:HIS257
|
4.5
|
33.8
|
1.0
|
CG2
|
J:VAL265
|
4.9
|
27.2
|
1.0
|
O
|
J:ASP415
|
5.0
|
30.9
|
1.0
|
|
Reference:
M.E.Lee,
J.Markowitz,
J.-O.Lee,
H.Lee.
Crystal Structure of Phosphodiesterase 4D and Inhibitor Complex Febs Lett. V. 530 53 2002.
ISSN: ISSN 0014-5793
PubMed: 12387865
DOI: 10.1016/S0014-5793(02)03396-3
Page generated: Wed Oct 16 16:57:09 2024
|