Zinc in PDB 1m5b: X-Ray Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with 2-Me-Tet-Ampa at 1.85 A Resolution.

The structure of X-Ray Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with 2-Me-Tet-Ampa at 1.85 A Resolution., PDB code: 1m5b was solved by A.Hogner, J.S.Kastrup, R.Jin, T.Liljefors, M.L.Mayer, J.Egebjerg, I.K.Larsen, E.Gouaux, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 1.85
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	114.410, 164.330, 47.310, 90.00, 90.00, 90.00
R / Rfree (%)	19.6 / 23.4

The binding sites of Zinc atom in the X-Ray Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with 2-Me-Tet-Ampa at 1.85 A Resolution. (pdb code 1m5b). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 5 binding sites of Zinc where determined in the X-Ray Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with 2-Me-Tet-Ampa at 1.85 A Resolution., PDB code: 1m5b:
Jump to Zinc binding site number: 1; 2; 3; 4; 5;

Zinc binding site 1 out of 5 in the X-Ray Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with 2-Me-Tet-Ampa at 1.85 A Resolution.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of X-Ray Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with 2-Me-Tet-Ampa at 1.85 A Resolution. within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn2103 b:30.6 occ:1.00 NE2 A:HIS23 2.5 26.4 1.0 O A:HOH2334 2.8 43.2 1.0 CD2 A:HIS23 3.3 26.6 1.0 CE1 A:HIS23 3.5 26.1 1.0 O A:HOH2258 3.8 48.4 1.0 OE2 A:GLU24 4.5 40.6 1.0 CG A:HIS23 4.5 26.1 1.0 ND1 A:HIS23 4.6 26.4 1.0 CB A:MET19 4.8 19.1 1.0 CG A:MET19 4.9 20.3 1.0 CD A:GLU24 5.0 38.8 1.0 CG A:GLU24 5.0 35.8 1.0

Zinc binding site 2 out of 5 in the X-Ray Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with 2-Me-Tet-Ampa at 1.85 A Resolution.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of X-Ray Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with 2-Me-Tet-Ampa at 1.85 A Resolution. within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn2104 b:23.0 occ:1.00 OE1 A:GLU42 2.3 18.7 1.0 OE2 B:GLU166 2.4 24.9 1.0 NE2 A:HIS46 2.4 21.3 1.0 OE1 B:GLU166 2.8 22.8 1.0 CD B:GLU166 3.0 23.6 1.0 CD A:GLU42 3.1 18.5 1.0 CD2 A:HIS46 3.2 21.3 1.0 OE2 A:GLU42 3.3 17.8 1.0 O B:HOH2299 3.4 8.2 1.0 CE1 A:HIS46 3.4 21.5 1.0 O B:HOH2393 3.9 47.6 1.0 N B:SER168 4.2 15.7 1.0 CD2 A:LEU241 4.2 18.7 1.0 CG A:HIS46 4.4 20.5 1.0 CG B:GLU166 4.4 21.7 1.0 ND1 A:HIS46 4.5 21.0 1.0 CG A:GLU42 4.5 16.3 1.0 CB B:SER168 4.6 16.3 1.0 O B:ALA165 4.7 15.6 1.0 CA B:SER168 4.7 15.6 1.0 CB A:GLU42 4.9 14.9 1.0 C B:PRO167 4.9 16.6 1.0 CA B:PRO167 5.0 16.9 1.0

Zinc binding site 3 out of 5 in the X-Ray Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with 2-Me-Tet-Ampa at 1.85 A Resolution.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of X-Ray Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with 2-Me-Tet-Ampa at 1.85 A Resolution. within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn2105 b:25.1 occ:1.00 NE2 B:HIS23 2.4 23.8 1.0 OE2 B:GLU30 2.5 23.5 1.0 OE1 B:GLU30 3.0 20.2 1.0 CD B:GLU30 3.1 21.9 1.0 CD2 B:HIS23 3.2 22.5 1.0 CE1 B:HIS23 3.5 23.0 1.0 CD B:LYS20 4.0 19.3 1.0 NZ B:LYS20 4.1 19.9 1.0 O B:GLU30 4.4 19.1 1.0 CG B:HIS23 4.4 23.1 1.0 CG B:GLU30 4.5 21.4 1.0 ND1 B:HIS23 4.5 23.0 1.0 CE B:LYS20 4.7 19.2 1.0 CD1 B:LEU26 4.8 29.2 1.0

Zinc binding site 4 out of 5 in the X-Ray Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with 2-Me-Tet-Ampa at 1.85 A Resolution.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of X-Ray Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with 2-Me-Tet-Ampa at 1.85 A Resolution. within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn2106 b:20.7 occ:1.00 NE2 B:HIS46 2.4 18.8 1.0 OE1 B:GLU42 2.4 17.3 1.0 O B:HOH2114 2.5 14.7 1.0 CD2 B:HIS46 3.1 18.9 1.0 CD B:GLU42 3.1 15.8 1.0 OE2 B:GLU42 3.3 15.9 1.0 CE1 B:HIS46 3.5 18.8 1.0 CD2 B:LEU241 3.6 18.4 1.0 OE1 B:GLN244 3.8 31.9 1.0 O B:HOH2321 4.0 40.9 1.0 NZ B:LYS45 4.0 19.6 1.0 O B:HOH2200 4.0 30.2 1.0 CE B:LYS45 4.0 19.8 1.0 CG B:HIS46 4.3 18.1 1.0 CG B:GLU42 4.4 14.1 1.0 ND1 B:HIS46 4.5 19.7 1.0 CB B:GLU42 4.7 12.1 1.0

Zinc binding site 5 out of 5 in the X-Ray Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with 2-Me-Tet-Ampa at 1.85 A Resolution.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of X-Ray Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with 2-Me-Tet-Ampa at 1.85 A Resolution. within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn2107 b:50.2 occ:1.00 OE1 C:GLU42 2.5 27.3 1.0 NE2 C:HIS46 2.6 31.4 1.0 O C:HOH2373 3.0 51.0 1.0 O C:HOH2152 3.2 42.7 1.0 CD C:GLU42 3.3 26.8 1.0 CD2 C:HIS46 3.4 30.0 1.0 NZ C:LYS45 3.4 32.4 1.0 OE2 C:GLU42 3.5 28.4 1.0 CE C:LYS45 3.6 31.3 1.0 CE1 C:HIS46 3.6 30.6 1.0 CD2 C:LEU241 3.9 20.1 1.0 CG C:GLU42 4.5 24.7 1.0 CG C:HIS46 4.6 29.4 1.0 ND1 C:HIS46 4.7 30.5 1.0 CB C:GLU42 4.8 21.8 1.0

A.Hogner, J.S.Kastrup, R.Jin, T.Liljefors, M.L.Mayer, J.Egebjerg, I.K.Larsen, E.Gouaux. Structural Basis For Ampa Receptor Activation and Ligand Selectivity: Crystal Structures of Five Agonist Complexes with the GLUR2 Ligand-Binding Core J.Mol.Biol. V. 322 93 2002.
ISSN: ISSN 0022-2836
PubMed: 12215417
DOI: 10.1016/S0022-2836(02)00650-2