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Atomistry » Zinc » PDB 1kzo-1lfw » 1ld8 » |
Zinc in PDB 1ld8: Co-Crystal Structure of Human Farnesyltransferase with Farnesyldiphosphate and Inhibitor Compound 49Protein crystallography data
The structure of Co-Crystal Structure of Human Farnesyltransferase with Farnesyldiphosphate and Inhibitor Compound 49, PDB code: 1ld8
was solved by
J.S.Taylor,
K.L.Terry,
L.S.Beese,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Zinc Binding Sites:
The binding sites of Zinc atom in the Co-Crystal Structure of Human Farnesyltransferase with Farnesyldiphosphate and Inhibitor Compound 49
(pdb code 1ld8). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Co-Crystal Structure of Human Farnesyltransferase with Farnesyldiphosphate and Inhibitor Compound 49, PDB code: 1ld8: Zinc binding site 1 out of 1 in 1ld8Go back to Zinc Binding Sites List in 1ld8
Zinc binding site 1 out
of 1 in the Co-Crystal Structure of Human Farnesyltransferase with Farnesyldiphosphate and Inhibitor Compound 49
Mono view Stereo pair view
Reference:
I.M.Bell,
S.N.Gallicchio,
M.Abrams,
L.S.Beese,
D.C.Beshore,
H.Bhimnathwala,
M.J.Bogusky,
C.A.Buser,
J.C.Culberson,
J.Davide,
M.Ellis-Hutchings,
C.Fernandes,
J.B.Gibbs,
S.L.Graham,
K.A.Hamilton,
G.D.Hartman,
D.C.Heimbrook,
C.F.Homnick,
H.E.Huber,
J.R.Huff,
K.Kassahun,
K.S.Koblan,
N.E.Kohl,
R.B.Lobell,
J.J.Lynch Jr.,
R.Robinson,
A.D.Rodrigues,
J.S.Taylor,
E.S.Walsh,
T.M.Williams,
C.B.Zartman.
3-Aminopyrrolidinone Farnesyltransferase Inhibitors: Design of Macrocyclic Compounds with Improved Pharmacokinetics and Excellent Cell Potency. J.Med.Chem. V. 45 2388 2002.
Page generated: Wed Dec 16 02:56:08 2020
ISSN: ISSN 0022-2623 PubMed: 12036349 DOI: 10.1021/JM010531D |
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