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Atomistry » Zinc » PDB 1kzo-1lfw » 1ld7 » |
Zinc in PDB 1ld7: Co-Crystal Structure of Human Farnesyltransferase with Farnesyldiphosphate and Inhibitor Compound 66Protein crystallography data
The structure of Co-Crystal Structure of Human Farnesyltransferase with Farnesyldiphosphate and Inhibitor Compound 66, PDB code: 1ld7
was solved by
J.S.Taylor,
K.L.Terry,
L.S.Beese,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Zinc Binding Sites:
The binding sites of Zinc atom in the Co-Crystal Structure of Human Farnesyltransferase with Farnesyldiphosphate and Inhibitor Compound 66
(pdb code 1ld7). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Co-Crystal Structure of Human Farnesyltransferase with Farnesyldiphosphate and Inhibitor Compound 66, PDB code: 1ld7: Zinc binding site 1 out of 1 in 1ld7Go back to Zinc Binding Sites List in 1ld7
Zinc binding site 1 out
of 1 in the Co-Crystal Structure of Human Farnesyltransferase with Farnesyldiphosphate and Inhibitor Compound 66
Mono view Stereo pair view
Reference:
I.M.Bell,
S.N.Gallicchio,
M.Abrams,
L.S.Beese,
D.C.Beshore,
H.Bhimnathwala,
M.J.Bogusky,
C.A.Buser,
J.C.Culberson,
J.Davide,
M.Ellis-Hutchings,
C.Fernandes,
J.B.Gibbs,
S.L.Graham,
K.A.Hamilton,
G.D.Hartman,
D.C.Heimbrook,
C.F.Homnick,
H.E.Huber,
J.R.Huff,
K.Kassahun,
K.S.Koblan,
N.E.Kohl,
R.B.Lobell,
J.J.Lynch Jr.,
R.Robinson,
A.D.Rodrigues,
J.S.Taylor,
E.S.Walsh,
T.M.Williams,
C.B.Zartman.
3-Aminopyrrolidinone Farnesyltransferase Inhibitors: Design of Macrocyclic Compounds with Improved Pharmacokinetics and Excellent Cell Potency. J.Med.Chem. V. 45 2388 2002.
Page generated: Wed Dec 16 02:56:08 2020
ISSN: ISSN 0022-2623 PubMed: 12036349 DOI: 10.1021/JM010531D |
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