Zinc in PDB 1lap: Molecular Structure of Leucine Aminopeptidase at 2.7-Angstroms Resolution

All present enzymatic activity of Molecular Structure of Leucine Aminopeptidase at 2.7-Angstroms Resolution:
3.4.11.1;

The structure of Molecular Structure of Leucine Aminopeptidase at 2.7-Angstroms Resolution, PDB code: 1lap was solved by S.K.Burley, P.R.David, A.Taylor, W.N.Lipscomb, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	N/A / 2.70
Space group	P 63 2 2
Cell size a, b, c (Å), α, β, γ (°)	132.500, 132.500, 121.800, 90.00, 90.00, 120.00
R / Rfree (%)	16.9 / n/a

The binding sites of Zinc atom in the Molecular Structure of Leucine Aminopeptidase at 2.7-Angstroms Resolution (pdb code 1lap). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Molecular Structure of Leucine Aminopeptidase at 2.7-Angstroms Resolution, PDB code: 1lap:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Molecular Structure of Leucine Aminopeptidase at 2.7-Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Molecular Structure of Leucine Aminopeptidase at 2.7-Angstroms Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn488 b:37.8 occ:1.00 OE2 A:GLU334 2.0 26.5 1.0 OD1 A:ASP255 2.1 23.1 1.0 OD2 A:ASP332 2.3 12.2 1.0 O A:ASP332 2.4 14.1 1.0 CD A:GLU334 2.9 25.2 1.0 CG A:ASP255 2.9 18.2 1.0 ZN A:ZN489 2.9 14.1 1.0 OD2 A:ASP255 3.0 16.0 1.0 OE1 A:GLU334 3.1 23.7 1.0 C A:ASP332 3.2 13.4 1.0 CG A:ASP332 3.3 15.7 1.0 H A:GLU334 3.4 20.0 1.0 CA A:ASP332 3.5 16.2 1.0 HZ1 A:LYS262 3.8 20.0 1.0 CB A:ASP332 3.9 15.1 1.0 HZ3 A:LYS250 4.0 20.0 1.0 HZ2 A:LYS262 4.0 20.0 1.0 OD1 A:ASP332 4.2 17.4 1.0 NZ A:LYS262 4.2 11.1 1.0 CG A:GLU334 4.2 26.9 1.0 CB A:ASP255 4.3 16.0 1.0 N A:GLU334 4.3 13.8 1.0 CE A:LYS262 4.4 10.3 1.0 N A:ALA333 4.4 12.7 1.0 H A:GLY335 4.4 20.0 1.0 OD1 A:ASN305 4.4 3.2 1.0 OD1 A:ASP273 4.5 13.0 1.0 H A:GLY257 4.7 20.0 1.0 CB A:GLU334 4.7 22.1 1.0 CA A:GLY257 4.9 10.0 1.0 O A:THR331 4.9 13.1 1.0 N A:ASP332 4.9 18.3 1.0 CA A:ALA333 4.9 7.8 1.0 NZ A:LYS250 4.9 16.7 1.0 CE A:MET270 4.9 24.6 1.0

Zinc binding site 2 out of 2 in the Molecular Structure of Leucine Aminopeptidase at 2.7-Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Molecular Structure of Leucine Aminopeptidase at 2.7-Angstroms Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn489 b:14.1 occ:1.00 HZ3 A:LYS250 1.2 20.0 1.0 OE1 A:GLU334 2.0 23.7 1.0 OD1 A:ASP273 2.0 13.0 1.0 NZ A:LYS250 2.3 16.7 1.0 OD1 A:ASP255 2.7 23.1 1.0 HZ2 A:LYS250 2.7 20.0 1.0 HZ1 A:LYS250 2.8 20.0 1.0 ZN A:ZN488 2.9 37.8 1.0 CD A:GLU334 2.9 25.2 1.0 CG A:ASP273 3.0 13.4 1.0 CE A:LYS250 3.1 11.8 1.0 OE2 A:GLU334 3.3 26.5 1.0 OD2 A:ASP273 3.3 14.7 1.0 CG A:ASP255 3.5 18.2 1.0 H A:GLY335 3.6 20.0 1.0 CB A:ASP255 4.0 16.0 1.0 OD2 A:ASP255 4.3 16.0 1.0 CG A:GLU334 4.3 26.9 1.0 CE A:MET270 4.3 24.6 1.0 CB A:ASP273 4.4 11.8 1.0 CD A:LYS250 4.5 9.0 1.0 CG1 A:ILE252 4.5 7.1 1.0 N A:GLY335 4.5 12.4 1.0 O A:THR359 4.5 9.2 1.0 HH12 A:ARG336 4.6 20.0 1.0 O A:ASP332 4.6 14.1 1.0 CB A:ILE252 4.6 6.3 1.0 CG2 A:ILE252 4.6 2.4 1.0 HH22 A:ARG336 4.7 20.0 1.0 H A:GLU334 4.7 20.0 1.0 HG1 A:THR359 4.8 20.0 1.0

S.K.Burley, P.R.David, A.Taylor, W.N.Lipscomb. Molecular Structure of Leucine Aminopeptidase at 2.7-A Resolution. Proc.Natl.Acad.Sci.Usa V. 87 6878 1990.
ISSN: ISSN 0027-8424
PubMed: 2395881
DOI: 10.1073/PNAS.87.17.6878