Zinc in PDB 1l8c: Structural Basis For Hif-1ALPHA/Cbp Recognition in the Cellular Hypoxic Response

The binding sites of Zinc atom in the Structural Basis For Hif-1ALPHA/Cbp Recognition in the Cellular Hypoxic Response (pdb code 1l8c). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Structural Basis For Hif-1ALPHA/Cbp Recognition in the Cellular Hypoxic Response, PDB code: 1l8c:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in the Structural Basis For Hif-1ALPHA/Cbp Recognition in the Cellular Hypoxic Response


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structural Basis For Hif-1ALPHA/Cbp Recognition in the Cellular Hypoxic Response within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn96 b:0.0 occ:1.00 NE2 A:HIS18 2.1 0.0 1.0 SG A:CYS40 2.3 0.0 1.0 SG A:CYS35 2.3 0.0 1.0 SG A:CYS22 2.3 0.0 1.0 HB2 A:CYS22 2.7 0.0 1.0 HA A:CYS35 2.8 0.0 1.0 CD2 A:HIS18 2.8 0.0 1.0 HD2 A:HIS18 2.8 0.0 1.0 CB A:CYS22 3.0 0.0 1.0 HB2 A:CYS40 3.0 0.0 1.0 HB2 A:CYS35 3.0 0.0 1.0 HZ3 A:LYS44 3.1 0.0 1.0 CB A:CYS40 3.1 0.0 1.0 CB A:CYS35 3.1 0.0 1.0 HB3 A:CYS22 3.2 0.0 1.0 HH12 A:ARG41 3.2 0.0 1.0 HZ1 A:LYS44 3.2 0.0 1.0 HB3 A:CYS40 3.3 0.0 1.0 CE1 A:HIS18 3.3 0.0 1.0 CA A:CYS35 3.4 0.0 1.0 H A:SER36 3.5 0.0 1.0 NZ A:LYS44 3.7 0.0 1.0 HE1 A:HIS18 3.7 0.0 1.0 HH22 A:ARG41 3.8 0.0 1.0 HH22 A:ARG33 4.0 0.0 1.0 HZ2 A:LYS44 4.1 0.0 1.0 CG A:HIS18 4.1 0.0 1.0 HB3 A:CYS35 4.1 0.0 1.0 NH1 A:ARG41 4.1 0.0 1.0 HA A:ALA19 4.3 0.0 1.0 ND1 A:HIS18 4.3 0.0 1.0 N A:CYS35 4.3 0.0 1.0 HH12 A:ARG33 4.4 0.0 1.0 N A:SER36 4.4 0.0 1.0 CA A:CYS22 4.4 0.0 1.0 C A:CYS35 4.5 0.0 1.0 CA A:CYS40 4.5 0.0 1.0 H A:CYS35 4.6 0.0 1.0 H A:LEU37 4.6 0.0 1.0 HH11 A:ARG41 4.6 0.0 1.0 HA A:CYS22 4.6 0.0 1.0 NH2 A:ARG41 4.7 0.0 1.0 O A:HIS18 4.7 0.0 1.0 O A:LEU37 4.8 0.0 1.0 HB2 A:LEU37 4.8 0.0 1.0 HA A:CYS40 4.8 0.0 1.0 HE2 A:LYS44 4.9 0.0 1.0 CE A:LYS44 4.9 0.0 1.0 H A:CYS22 4.9 0.0 1.0 CZ A:ARG41 4.9 0.0 1.0 NH2 A:ARG33 4.9 0.0 1.0

Zinc binding site 2 out of 3 in the Structural Basis For Hif-1ALPHA/Cbp Recognition in the Cellular Hypoxic Response


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structural Basis For Hif-1ALPHA/Cbp Recognition in the Cellular Hypoxic Response within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn97 b:0.0 occ:1.00 NE2 A:HIS49 2.1 0.0 1.0 SG A:CYS64 2.3 0.0 1.0 SG A:CYS53 2.3 0.0 1.0 SG A:CYS59 2.3 0.0 1.0 HH21 A:ARG68 2.8 0.0 1.0 HB2 A:CYS64 3.0 0.0 1.0 CD2 A:HIS49 3.1 0.0 1.0 CB A:CYS64 3.1 0.0 1.0 CB A:CYS53 3.1 0.0 1.0 CE1 A:HIS49 3.1 0.0 1.0 HB3 A:CYS53 3.1 0.0 1.0 HB2 A:CYS53 3.2 0.0 1.0 HB2 A:CYS59 3.2 0.0 1.0 HB3 A:CYS64 3.3 0.0 1.0 HD2 A:HIS49 3.3 0.0 1.0 CB A:CYS59 3.3 0.0 1.0 HE1 A:HIS49 3.4 0.0 1.0 HB3 A:CYS59 3.5 0.0 1.0 NH2 A:ARG68 3.8 0.0 1.0 HE A:ARG68 3.8 0.0 1.0 HB A:VAL61 4.1 0.0 1.0 HB3 A:ALA55 4.2 0.0 1.0 CG A:HIS49 4.2 0.0 1.0 ND1 A:HIS49 4.2 0.0 1.0 HH22 A:ARG68 4.3 0.0 1.0 H A:GLY56 4.4 0.0 1.0 CA A:CYS64 4.5 0.0 1.0 CA A:CYS53 4.6 0.0 1.0 CA A:CYS59 4.7 0.0 1.0 NE A:ARG68 4.7 0.0 1.0 HA A:MET50 4.7 0.0 1.0 CZ A:ARG68 4.7 0.0 1.0 H A:ALA55 4.8 0.0 1.0 HA A:CYS64 4.8 0.0 1.0 HA A:CYS59 4.8 0.0 1.0 HA A:CYS53 4.9 0.0 1.0 HG22 A:VAL61 5.0 0.0 1.0 HG21 A:VAL61 5.0 0.0 1.0

Zinc binding site 3 out of 3 in the Structural Basis For Hif-1ALPHA/Cbp Recognition in the Cellular Hypoxic Response


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Structural Basis For Hif-1ALPHA/Cbp Recognition in the Cellular Hypoxic Response within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn98 b:0.0 occ:1.00 NE2 A:HIS73 2.1 0.0 1.0 HH21 A:ARG79 2.1 0.0 1.0 SG A:CYS85 2.3 0.0 1.0 SG A:CYS82 2.3 0.0 1.0 SG A:CYS77 2.3 0.0 1.0 CD2 A:HIS73 2.8 0.0 1.0 HD2 A:HIS73 2.8 0.0 1.0 HB2 A:CYS77 3.1 0.0 1.0 NH2 A:ARG79 3.1 0.0 1.0 CB A:CYS77 3.1 0.0 1.0 HB3 A:CYS82 3.3 0.0 1.0 CB A:CYS82 3.3 0.0 1.0 HB3 A:CYS77 3.3 0.0 1.0 CE1 A:HIS73 3.3 0.0 1.0 HB2 A:CYS85 3.4 0.0 1.0 HE A:ARG79 3.4 0.0 1.0 HB2 A:CYS82 3.4 0.0 1.0 HH22 A:ARG79 3.4 0.0 1.0 CB A:CYS85 3.4 0.0 1.0 HE1 A:HIS73 3.8 0.0 1.0 HB3 A:CYS85 3.9 0.0 1.0 H A:CYS85 3.9 0.0 1.0 CZ A:ARG79 4.0 0.0 1.0 CG A:HIS73 4.1 0.0 1.0 NE A:ARG79 4.1 0.0 1.0 ND1 A:HIS73 4.3 0.0 1.0 HB3 A:ARG79 4.4 0.0 1.0 CA A:CYS77 4.6 0.0 1.0 HA A:TRP74 4.6 0.0 1.0 CA A:CYS82 4.7 0.0 1.0 CA A:CYS85 4.8 0.0 1.0 HA A:CYS77 4.8 0.0 1.0 N A:CYS85 4.8 0.0 1.0 HD2 A:PRO83 4.8 0.0 1.0 H A:VAL84 5.0 0.0 1.0

S.A.Dames, M.Martinez-Yamout, R.N.De Guzman, H.J.Dyson, P.E.Wright. Structural Basis For Hif-1 Alpha /Cbp Recognition in the Cellular Hypoxic Response. Proc.Natl.Acad.Sci.Usa V. 99 5271 2002.
ISSN: ISSN 0027-8424
PubMed: 11959977
DOI: 10.1073/PNAS.082121399