Zinc in PDB 1jcs: Crystal Structure of Rat Protein Farnesyltransferase Complexed with the Peptide Substrate Tkcvfm and An Analog of Farnesyl Diphosphate

The structure of Crystal Structure of Rat Protein Farnesyltransferase Complexed with the Peptide Substrate Tkcvfm and An Analog of Farnesyl Diphosphate, PDB code: 1jcs was solved by S.B.Long, P.J.Casey, L.S.Beese, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 2.20
Space group	P 61
Cell size a, b, c (Å), α, β, γ (°)	170.921, 170.921, 69.425, 90.00, 90.00, 120.00
R / Rfree (%)	16 / 20.2

The binding sites of Zinc atom in the Crystal Structure of Rat Protein Farnesyltransferase Complexed with the Peptide Substrate Tkcvfm and An Analog of Farnesyl Diphosphate (pdb code 1jcs). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Rat Protein Farnesyltransferase Complexed with the Peptide Substrate Tkcvfm and An Analog of Farnesyl Diphosphate, PDB code: 1jcs:

Zinc binding site 1 out of 1 in the Crystal Structure of Rat Protein Farnesyltransferase Complexed with the Peptide Substrate Tkcvfm and An Analog of Farnesyl Diphosphate


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Rat Protein Farnesyltransferase Complexed with the Peptide Substrate Tkcvfm and An Analog of Farnesyl Diphosphate within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1001 b:23.4 occ:1.00 OD2 B:ASP297 2.1 17.6 1.0 NE2 B:HIS362 2.2 22.3 1.0 SG B:CYS299 2.2 21.5 1.0 SG C:CYS3 2.3 34.5 1.0 OD1 B:ASP297 2.6 18.2 1.0 CG B:ASP297 2.6 19.2 1.0 CE1 B:HIS362 3.1 21.7 1.0 CD2 B:HIS362 3.1 20.4 1.0 CB B:CYS299 3.3 15.0 1.0 CB C:CYS3 3.7 53.9 1.0 CE2 B:TYR361 3.8 24.2 1.0 CB B:ASP297 4.1 18.2 1.0 O B:HOH1175 4.1 36.2 1.0 N B:CYS299 4.1 19.3 1.0 O B:HOH1207 4.1 32.8 1.0 ND1 B:HIS362 4.2 23.4 1.0 CG B:HIS362 4.2 21.5 1.0 CA B:CYS299 4.3 18.4 1.0 O B:HOH1164 4.4 14.7 1.0 CB B:ASP352 4.5 21.5 1.0 CG B:ASP352 4.6 24.6 1.0 CD2 B:TYR361 4.6 20.4 1.0 OH B:TYR361 4.7 27.9 1.0 OD2 B:ASP352 4.8 27.0 1.0 CZ B:TYR361 4.8 21.0 1.0 CA B:ASP352 4.9 23.0 1.0 OD1 B:ASP352 5.0 26.9 1.0

S.B.Long, P.J.Hancock, A.M.Kral, H.W.Hellinga, L.S.Beese. The Crystal Structure of Human Protein Farnesyltransferase Reveals the Basis For Inhibition By Caax Tetrapeptides and Their Mimetics. Proc.Natl.Acad.Sci.Usa V. 98 12948 2001.
ISSN: ISSN 0027-8424
PubMed: 11687658
DOI: 10.1073/PNAS.241407898