Zinc in PDB 1j7n: Anthrax Toxin Lethal Factor

The structure of Anthrax Toxin Lethal Factor, PDB code: 1j7n was solved by A.D.Pannifer, T.Y.Wong, R.Schwarzenbacher, M.Renatus, C.Petosa, R.J.Collier, J.Bienkowska, D.B.Lacy, S.Park, S.H.Leppla, P.Hanna, R.C.Liddington, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	15.00 / 2.30
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	96.201, 137.461, 98.547, 90.00, 98.35, 90.00
R / Rfree (%)	22.9 / 26.1

The binding sites of Zinc atom in the Anthrax Toxin Lethal Factor (pdb code 1j7n). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Anthrax Toxin Lethal Factor, PDB code: 1j7n:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Anthrax Toxin Lethal Factor


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Anthrax Toxin Lethal Factor within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn9001 b:45.0 occ:1.00 OE1 A:GLU735 2.2 49.9 1.0 NE2 A:HIS686 2.3 34.2 1.0 NE2 A:HIS690 2.4 48.5 1.0 O A:HOH9437 2.6 44.6 1.0 CD2 A:HIS690 3.1 46.2 1.0 CD A:GLU735 3.1 51.4 1.0 CD2 A:HIS686 3.1 35.1 1.0 OH A:TYR728 3.2 58.2 1.0 OE2 A:GLU735 3.2 52.9 1.0 CE1 A:HIS686 3.3 35.6 1.0 CE1 A:HIS690 3.5 48.2 1.0 O A:HOH9255 3.9 53.7 1.0 CZ A:TYR728 4.0 59.5 1.0 OE1 A:GLU687 4.1 42.3 1.0 CG A:HIS686 4.3 34.9 1.0 CG A:HIS690 4.3 46.8 1.0 ND1 A:HIS686 4.4 36.6 1.0 OE2 A:GLU687 4.4 41.5 1.0 CB A:ALA738 4.4 47.4 1.0 CG A:GLU735 4.5 52.0 1.0 ND1 A:HIS690 4.5 48.1 1.0 CD A:GLU687 4.6 39.0 1.0 CE2 A:TYR728 4.6 59.2 1.0 CE1 A:TYR728 4.7 59.3 1.0 CA A:GLU735 4.8 53.3 1.0 CB A:GLU735 4.9 52.8 1.0 O A:HOH9244 5.0 47.3 1.0

Zinc binding site 2 out of 2 in the Anthrax Toxin Lethal Factor


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Anthrax Toxin Lethal Factor within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn9002 b:39.5 occ:1.00 NE2 B:HIS690 2.1 27.9 1.0 O B:HOH9258 2.1 36.5 1.0 OE1 B:GLU735 2.3 48.6 1.0 NE2 B:HIS686 2.3 36.3 1.0 OE2 B:GLU735 2.9 45.6 1.0 CD B:GLU735 2.9 47.5 1.0 CD2 B:HIS690 3.0 32.0 1.0 CE1 B:HIS690 3.2 33.9 1.0 CD2 B:HIS686 3.2 38.4 1.0 CE1 B:HIS686 3.3 37.2 1.0 OH B:TYR728 3.5 64.2 1.0 OE1 B:GLU687 4.1 32.7 1.0 CG B:HIS690 4.2 33.5 1.0 ND1 B:HIS690 4.2 34.2 1.0 OE2 B:GLU687 4.3 34.5 1.0 ND1 B:HIS686 4.3 37.8 1.0 CG B:HIS686 4.4 37.6 1.0 CZ B:TYR728 4.4 63.8 1.0 CB B:ALA738 4.4 38.8 1.0 CG B:GLU735 4.4 45.5 1.0 CE2 B:TYR728 4.5 63.4 1.0 CD B:GLU687 4.5 33.3 1.0 CA B:GLU735 4.8 42.6 1.0 CB B:GLU735 5.0 43.1 1.0

A.D.Pannifer, T.Y.Wong, R.Schwarzenbacher, M.Renatus, C.Petosa, J.Bienkowska, D.B.Lacy, R.J.Collier, S.Park, S.H.Leppla, P.Hanna, R.C.Liddington. Crystal Structure of the Anthrax Lethal Factor. Nature V. 414 229 2001.
ISSN: ISSN 0028-0836
PubMed: 11700563
DOI: 10.1038/N35101998