Zinc in PDB 1hov: Solution Structure of A Catalytic Domain of Mmp-2 Complexed with Sc-74020

All present enzymatic activity of Solution Structure of A Catalytic Domain of Mmp-2 Complexed with Sc-74020:
3.4.24.24;

The structure of Solution Structure of A Catalytic Domain of Mmp-2 Complexed with Sc-74020 also contains other interesting chemical elements:

Calcium

(Ca)

22 atoms

The binding sites of Zinc atom in the Solution Structure of A Catalytic Domain of Mmp-2 Complexed with Sc-74020 (pdb code 1hov). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Solution Structure of A Catalytic Domain of Mmp-2 Complexed with Sc-74020, PDB code: 1hov:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Solution Structure of A Catalytic Domain of Mmp-2 Complexed with Sc-74020


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Solution Structure of A Catalytic Domain of Mmp-2 Complexed with Sc-74020 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn165 b:11.6 occ:1.00 HD1 A:HIS98 1.7 0.0 1.0 NE2 A:HIS85 2.1 0.0 1.0 NE2 A:HIS70 2.1 0.0 1.0 ND1 A:HIS98 2.3 0.0 1.0 OD2 A:ASP72 2.3 0.0 1.0 CE1 A:HIS98 2.8 0.0 1.0 CE1 A:HIS85 2.8 0.0 1.0 HE1 A:HIS98 2.9 0.0 1.0 HE1 A:HIS85 2.9 0.0 1.0 CE1 A:HIS70 3.0 0.0 1.0 HE1 A:HIS70 3.1 0.0 1.0 CG A:ASP72 3.2 0.0 1.0 CD2 A:HIS70 3.3 0.0 1.0 CD2 A:HIS85 3.3 0.0 1.0 CG A:HIS98 3.3 0.0 1.0 HB2 A:HIS98 3.6 0.0 1.0 HD2 A:HIS70 3.6 0.0 1.0 OD1 A:ASP72 3.6 0.0 1.0 HD2 A:HIS85 3.7 0.0 1.0 CB A:HIS98 4.0 0.0 1.0 NE2 A:HIS98 4.0 0.0 1.0 ND1 A:HIS85 4.1 0.0 1.0 ND1 A:HIS70 4.2 0.0 1.0 CD2 A:HIS98 4.2 0.0 1.0 CG A:HIS85 4.3 0.0 1.0 CG A:HIS70 4.3 0.0 1.0 HB3 A:HIS98 4.4 0.0 1.0 HB2 A:ASP72 4.4 0.0 1.0 CB A:ASP72 4.5 0.0 1.0 HA2 A:GLY66 4.8 0.0 1.0 HD1 A:PHE87 4.8 0.0 1.0 HD1 A:HIS85 4.9 0.0 1.0 HB3 A:ASP72 5.0 0.0 1.0

Zinc binding site 2 out of 2 in the Solution Structure of A Catalytic Domain of Mmp-2 Complexed with Sc-74020


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Solution Structure of A Catalytic Domain of Mmp-2 Complexed with Sc-74020 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn166 b:10.6 occ:1.00 NE2 A:HIS130 2.1 0.0 1.0 O1 A:I52800 2.1 20.0 1.0 O26 A:I52800 2.1 20.0 1.0 NE2 A:HIS120 2.2 0.0 1.0 NE2 A:HIS124 2.3 0.0 1.0 C3 A:I52800 2.7 20.0 1.0 N2 A:I52800 2.7 20.0 1.0 CE1 A:HIS130 2.8 0.0 1.0 HE1 A:HIS130 2.8 0.0 1.0 H1 A:I52800 2.9 20.0 1.0 CD2 A:HIS124 2.9 0.0 1.0 HD2 A:HIS124 3.0 0.0 1.0 CE1 A:HIS120 3.2 0.0 1.0 CD2 A:HIS120 3.2 0.0 1.0 CE1 A:HIS124 3.2 0.0 1.0 CD2 A:HIS130 3.3 0.0 1.0 HE1 A:HIS120 3.4 0.0 1.0 HD2 A:HIS120 3.4 0.0 1.0 H2 A:I52800 3.7 20.0 1.0 HE1 A:HIS124 3.7 0.0 1.0 HD2 A:HIS130 3.7 0.0 1.0 CG A:HIS124 4.0 0.0 1.0 ND1 A:HIS130 4.1 0.0 1.0 ND1 A:HIS124 4.1 0.0 1.0 C4 A:I52800 4.1 20.0 1.0 CG A:HIS130 4.3 0.0 1.0 ND1 A:HIS120 4.3 0.0 1.0 H62 A:I52800 4.4 20.0 1.0 CG A:HIS120 4.4 0.0 1.0 C16 A:I52800 4.5 20.0 1.0 N5 A:I52800 4.5 20.0 1.0 H61 A:I52800 4.6 20.0 1.0 H16 A:I52800 4.6 20.0 2.0 H4 A:I52800 4.6 20.0 1.0 C17 A:I52800 4.6 20.0 1.0 C6 A:I52800 4.8 20.0 1.0 HA A:MET138 4.8 0.0 1.0 OE2 A:GLU121 4.8 0.0 1.0 H17 A:I52800 4.8 20.0 2.0 C15 A:I52800 4.8 20.0 1.0 H23 A:I52800 4.8 20.0 1.0 HD1 A:HIS130 4.9 0.0 1.0 O A:MET138 4.9 0.0 1.0 HD1 A:HIS124 5.0 0.0 1.0

Y.Feng, J.J.Likos, L.Zhu, H.Woodward, G.Munie, J.J.Mcdonald, A.M.Stevens, C.P.Howard, G.A.De Crescenzo, D.Welsch, H.-S.Shieh, W.C.Stallings. Solution Structure and Backbone Dynamics of the Catalytic Domain of Matrix Metalloproteinase-2 Complexed with A Hydroxamic Acid Inhibitor Biochim.Biophys.Acta V.1598 10 2002.
ISSN: ISSN 0006-3002
PubMed: 12147339
DOI: 10.1016/S0167-4838(02)00307-2