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Zinc in PDB 1hfc: 1.56 Angstrom Structure of Mature Truncated Human Fibroblast Collagenase

Enzymatic activity of 1.56 Angstrom Structure of Mature Truncated Human Fibroblast Collagenase

All present enzymatic activity of 1.56 Angstrom Structure of Mature Truncated Human Fibroblast Collagenase:
3.4.24.7;

Protein crystallography data

The structure of 1.56 Angstrom Structure of Mature Truncated Human Fibroblast Collagenase, PDB code: 1hfc was solved by J.C.Spurlino, D.L.Smith, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 10.00 / 1.50
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 109.210, 44.570, 36.280, 90.00, 90.00, 90.00
R / Rfree (%) n/a / n/a

Other elements in 1hfc:

The structure of 1.56 Angstrom Structure of Mature Truncated Human Fibroblast Collagenase also contains other interesting chemical elements:

Calcium (Ca) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the 1.56 Angstrom Structure of Mature Truncated Human Fibroblast Collagenase (pdb code 1hfc). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the 1.56 Angstrom Structure of Mature Truncated Human Fibroblast Collagenase, PDB code: 1hfc:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 1hfc

Go back to Zinc Binding Sites List in 1hfc
Zinc binding site 1 out of 2 in the 1.56 Angstrom Structure of Mature Truncated Human Fibroblast Collagenase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of 1.56 Angstrom Structure of Mature Truncated Human Fibroblast Collagenase within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn275

b:6.3
occ:1.00
NE2 A:HIS218 1.9 2.6 1.0
NE2 A:HIS228 2.0 3.2 1.0
O2 A:PLH280 2.1 4.0 1.0
NE2 A:HIS222 2.1 5.1 1.0
O1 A:PLH280 2.2 5.4 1.0
C1 A:PLH280 2.7 4.5 1.0
CD2 A:HIS218 2.9 3.9 1.0
N1 A:PLH280 3.0 4.7 1.0
CE1 A:HIS228 3.0 7.8 1.0
CE1 A:HIS218 3.0 1.4 1.0
CE1 A:HIS222 3.0 9.7 1.0
CD2 A:HIS228 3.1 4.2 1.0
CD2 A:HIS222 3.1 6.2 1.0
C2 A:PLH280 4.1 3.4 1.0
CG A:HIS218 4.2 3.5 1.0
ND1 A:HIS218 4.2 5.2 1.0
ND1 A:HIS222 4.2 7.8 1.0
ND1 A:HIS228 4.2 9.0 1.0
O A:HOH295 4.2 11.3 1.0
CG A:HIS222 4.2 6.1 1.0
CG A:HIS228 4.2 6.7 1.0
OE1 A:GLU219 4.3 6.4 1.0
O A:HOH312 4.6 17.5 1.0
OE2 A:GLU219 4.7 6.3 1.0
C3 A:PLH280 4.7 4.0 1.0
O A:HOH292 4.7 33.8 1.0
C4 A:PLH280 4.8 7.5 1.0
CD A:GLU219 4.9 5.5 1.0
CE A:MET236 5.0 3.9 1.0

Zinc binding site 2 out of 2 in 1hfc

Go back to Zinc Binding Sites List in 1hfc
Zinc binding site 2 out of 2 in the 1.56 Angstrom Structure of Mature Truncated Human Fibroblast Collagenase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of 1.56 Angstrom Structure of Mature Truncated Human Fibroblast Collagenase within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn276

b:7.6
occ:1.00
OD2 A:ASP170 1.9 8.4 1.0
NE2 A:HIS183 1.9 6.1 1.0
ND1 A:HIS196 2.1 5.2 1.0
NE2 A:HIS168 2.1 5.1 1.0
CG A:ASP170 2.9 9.5 1.0
CE1 A:HIS183 2.9 9.7 1.0
CD2 A:HIS168 3.0 5.0 1.0
CE1 A:HIS196 3.0 9.0 1.0
CD2 A:HIS183 3.1 5.7 1.0
CG A:HIS196 3.1 4.9 1.0
OD1 A:ASP170 3.1 9.0 1.0
CE1 A:HIS168 3.2 6.8 1.0
CB A:HIS196 3.5 6.3 1.0
NE2 A:HIS196 4.1 6.7 1.0
ND1 A:HIS183 4.1 10.6 1.0
ND1 A:HIS168 4.1 6.5 1.0
CB A:ASP170 4.2 6.8 1.0
CG A:HIS168 4.2 6.9 1.0
CG A:HIS183 4.2 6.5 1.0
CE2 A:PHE185 4.3 10.7 1.0
CD2 A:HIS196 4.3 5.2 1.0
O A:SER172 4.3 7.1 1.0
CZ A:PHE185 4.4 14.6 1.0
CE2 A:PHE174 4.7 7.3 1.0
CZ A:PHE174 4.8 6.9 1.0
CB A:SER172 4.9 15.7 1.0
CG2 A:VAL164 4.9 10.2 1.0
O A:HOH307 5.0 8.3 1.0

Reference:

J.C.Spurlino, A.M.Smallwood, D.D.Carlton, T.M.Banks, K.J.Vavra, J.S.Johnson, E.R.Cook, J.Falvo, R.C.Wahl, T.A.Pulvino, J.J.Wendoloski, D.L.Smith. 1.56 A Structure of Mature Truncated Human Fibroblast Collagenase. Proteins V. 19 98 1994.
ISSN: ISSN 0887-3585
PubMed: 8090713
DOI: 10.1002/PROT.340190203
Page generated: Wed Dec 16 02:51:13 2020

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