Zinc in PDB 1h2m: Factor Inhibiting Hif-1 Alpha in Complex with Hif-1 Alpha Fragment Peptide

The structure of Factor Inhibiting Hif-1 Alpha in Complex with Hif-1 Alpha Fragment Peptide, PDB code: 1h2m was solved by J.M.Elkins, K.S.Hewitson, L.A.Mcneill, I.Schlemminger, J.F.Seibel, C.J.Schofield, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	18.00 / 2.50
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	86.249, 86.249, 148.260, 90.00, 90.00, 90.00
R / Rfree (%)	19.2 / 22.5

The binding sites of Zinc atom in the Factor Inhibiting Hif-1 Alpha in Complex with Hif-1 Alpha Fragment Peptide (pdb code 1h2m). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Factor Inhibiting Hif-1 Alpha in Complex with Hif-1 Alpha Fragment Peptide, PDB code: 1h2m:

Zinc binding site 1 out of 1 in the Factor Inhibiting Hif-1 Alpha in Complex with Hif-1 Alpha Fragment Peptide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Factor Inhibiting Hif-1 Alpha in Complex with Hif-1 Alpha Fragment Peptide within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1350 b:32.3 occ:1.00 NE2 A:HIS279 2.0 30.9 1.0 O2 A:OGA1351 2.0 33.8 1.0 NE2 A:HIS199 2.0 30.4 1.0 OD2 A:ASP201 2.1 27.2 1.0 O2' A:OGA1351 2.1 31.0 1.0 C1 A:OGA1351 2.7 34.8 1.0 C2 A:OGA1351 2.7 32.9 1.0 CE1 A:HIS279 2.9 31.5 1.0 CE1 A:HIS199 2.9 29.7 1.0 CD2 A:HIS279 3.0 31.9 1.0 CG A:ASP201 3.1 25.1 1.0 CD2 A:HIS199 3.1 29.6 1.0 OD1 A:ASP201 3.4 23.5 1.0 O1 A:OGA1351 3.9 33.5 1.0 O A:HOH2047 3.9 38.2 1.0 N1 A:OGA1351 4.0 29.8 1.0 ND1 A:HIS279 4.0 31.2 1.0 ND1 A:HIS199 4.1 30.0 1.0 CG A:HIS279 4.1 30.3 1.0 CG A:HIS199 4.2 29.7 1.0 CZ2 A:TRP296 4.3 35.6 1.0 CB A:ASP201 4.5 26.3 1.0 CB S:ASN803 4.8 53.0 1.0 CG S:ASN803 4.8 51.6 1.0 C4 A:OGA1351 4.8 32.2 1.0 ND2 S:ASN803 4.8 46.3 1.0

J.M.Elkins, K.S.Hewitson, L.A.Mcneill, J.F.Seibel, I.Schlemminger, C.Pugh, P.Ratcliffe, C.J.Schofield. Structure of Factor-Inhibiting Hypoxia-Inducible Factor (Hif) Reveals Mechanism of Oxidative Modification of Hif-1ALPHA J.Biol.Chem. V. 278 1802 2003.
ISSN: ISSN 0021-9258
PubMed: 12446723
DOI: 10.1074/JBC.C200644200