Zinc in PDB 1gzh: Crystal Structure of the Brct Domains of Human 53BP1 Bound to the P53 Tumor Supressor

The structure of Crystal Structure of the Brct Domains of Human 53BP1 Bound to the P53 Tumor Supressor, PDB code: 1gzh was solved by D.J.Derbyshire, A.J.Doherty, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	38.84 / 2.6
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	71.520, 94.570, 136.200, 90.00, 90.00, 90.00
R / Rfree (%)	23.8 / 28.8

The binding sites of Zinc atom in the Crystal Structure of the Brct Domains of Human 53BP1 Bound to the P53 Tumor Supressor (pdb code 1gzh). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of the Brct Domains of Human 53BP1 Bound to the P53 Tumor Supressor, PDB code: 1gzh:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of the Brct Domains of Human 53BP1 Bound to the P53 Tumor Supressor


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the Brct Domains of Human 53BP1 Bound to the P53 Tumor Supressor within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1293 b:31.1 occ:1.00 ND1 A:HIS179 2.2 34.6 1.0 SG A:CYS242 2.2 32.6 1.0 SG A:CYS238 2.4 25.8 1.0 SG A:CYS176 2.5 24.2 1.0 CB A:CYS242 3.1 33.0 1.0 CE1 A:HIS179 3.1 35.1 1.0 CG A:HIS179 3.3 33.7 1.0 CB A:CYS238 3.4 27.9 1.0 CB A:CYS176 3.6 25.4 1.0 CB A:HIS179 3.6 34.2 1.0 CA A:CYS238 3.9 27.8 1.0 N A:CYS176 4.0 27.0 1.0 NE2 A:HIS179 4.3 36.6 1.0 CD2 A:HIS179 4.4 34.4 1.0 CA A:CYS176 4.4 24.2 1.0 N A:HIS179 4.5 37.3 1.0 CA A:CYS242 4.5 30.0 1.0 O A:HOH2015 4.5 28.5 1.0 N A:ASN239 4.5 25.5 1.0 CA A:HIS179 4.7 37.3 1.0 O A:MET237 4.7 27.5 1.0 C A:CYS238 4.7 27.1 1.0 O A:CYS176 4.9 22.3 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of the Brct Domains of Human 53BP1 Bound to the P53 Tumor Supressor


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of the Brct Domains of Human 53BP1 Bound to the P53 Tumor Supressor within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn1290 b:31.4 occ:1.00 SG C:CYS238 2.2 36.9 1.0 ND1 C:HIS179 2.3 44.4 1.0 SG C:CYS242 2.4 33.0 1.0 SG C:CYS176 2.4 28.2 1.0 CE1 C:HIS179 3.0 43.5 1.0 CG C:HIS179 3.0 42.0 1.0 CB C:CYS242 3.2 33.1 1.0 CB C:CYS238 3.4 34.3 1.0 CB C:HIS179 3.5 40.3 1.0 CB C:CYS176 3.6 24.7 1.0 NE2 C:HIS179 3.9 43.2 1.0 CA C:CYS238 3.9 31.1 1.0 N C:CYS176 3.9 25.9 1.0 CD2 C:HIS179 3.9 42.5 1.0 CA C:CYS176 4.3 25.5 1.0 N C:HIS179 4.4 36.3 1.0 N C:ASN239 4.6 31.6 1.0 CA C:CYS242 4.6 33.1 1.0 CA C:HIS179 4.6 38.6 1.0 O C:MET237 4.6 28.4 1.0 C C:CYS238 4.7 31.0 1.0 O C:CYS176 4.9 25.1 1.0 C C:ARG175 5.0 28.2 1.0 C C:CYS176 5.0 25.9 1.0

D.J.Derbyshire, B.P.Basu, L.Serpell, W.Joo, T.Date, K.Iwabuchi, A.J.Doherty. Crystal Structure of Human 53BP1 Brct Domains Bound to P53 Tumour Suppressor Embo J. V. 21 3863 2002.
ISSN: ISSN 0261-4189
PubMed: 12110597
DOI: 10.1093/EMBOJ/CDF383