Zinc in PDB 1gtq: 6-Pyruvoyl Tetrahydropterin Synthase

All present enzymatic activity of 6-Pyruvoyl Tetrahydropterin Synthase:
4.6.1.10;

The structure of 6-Pyruvoyl Tetrahydropterin Synthase, PDB code: 1gtq was solved by H.Nar, R.Huber, C.W.Heizmann, B.Thoeny, D.Buergisser, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	8.00 / 2.30
Space group	P 3 2 1
Cell size a, b, c (Å), α, β, γ (°)	122.300, 122.300, 61.600, 90.00, 90.00, 120.00
R / Rfree (%)	20.4 / n/a

The binding sites of Zinc atom in the 6-Pyruvoyl Tetrahydropterin Synthase (pdb code 1gtq). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the 6-Pyruvoyl Tetrahydropterin Synthase, PDB code: 1gtq:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the 6-Pyruvoyl Tetrahydropterin Synthase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of 6-Pyruvoyl Tetrahydropterin Synthase within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn200 b:12.0 occ:1.00 NE2 A:HIS50 2.2 3.4 1.0 NE2 A:HIS48 2.2 18.0 1.0 NE2 A:HIS23 2.3 8.5 1.0 CE1 A:HIS23 2.9 5.4 1.0 CD2 A:HIS48 3.2 17.2 1.0 CE1 A:HIS50 3.2 2.6 1.0 CD2 A:HIS50 3.2 3.0 1.0 CE1 A:HIS48 3.3 16.9 1.0 OE2 A:GLU133 3.5 24.4 1.0 CD2 A:HIS23 3.5 8.7 1.0 CD A:GLU133 3.8 21.4 1.0 ND1 A:HIS23 4.2 5.2 1.0 OE1 A:GLU133 4.2 26.5 1.0 ND1 A:HIS50 4.3 4.8 1.0 CG A:HIS48 4.4 15.3 1.0 CG A:HIS50 4.4 2.2 1.0 ND1 A:HIS48 4.4 15.2 1.0 SG A:CYS42 4.5 12.3 1.0 CG A:HIS23 4.5 4.2 1.0 CG A:GLU133 4.5 14.1 1.0 H2 A:HOH505 4.8 20.0 1.0 HH A:TYR52 4.8 20.0 1.0 CB A:CYS42 4.9 12.2 1.0 HD1 A:HIS23 5.0 20.0 1.0

Zinc binding site 2 out of 2 in the 6-Pyruvoyl Tetrahydropterin Synthase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of 6-Pyruvoyl Tetrahydropterin Synthase within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn200 b:12.0 occ:1.00 NE2 B:HIS50 2.1 6.1 1.0 NE2 B:HIS48 2.2 11.0 1.0 NE2 B:HIS23 2.3 13.5 1.0 CE1 B:HIS50 3.0 4.9 1.0 CD2 B:HIS50 3.2 4.5 1.0 OE2 B:GLU133 3.2 29.4 1.0 CE1 B:HIS48 3.2 13.5 1.0 CE1 B:HIS23 3.2 13.0 1.0 CD2 B:HIS48 3.3 11.6 1.0 CD2 B:HIS23 3.4 12.5 1.0 CD B:GLU133 3.7 27.6 1.0 OE1 B:GLU133 4.0 33.7 1.0 ND1 B:HIS50 4.2 2.0 1.0 CG B:HIS50 4.3 2.3 1.0 ND1 B:HIS48 4.4 14.7 1.0 ND1 B:HIS23 4.4 12.4 1.0 SG B:CYS42 4.4 22.4 1.0 CG B:HIS48 4.4 12.2 1.0 H1 B:HOH528 4.5 20.0 1.0 CG B:HIS23 4.6 8.7 1.0 HH B:TYR52 4.6 20.0 1.0 CG B:GLU133 4.6 22.8 1.0 CB B:CYS42 4.8 21.9 1.0 OH B:TYR52 5.0 2.7 1.0

H.Nar, R.Huber, C.W.Heizmann, B.Thony, D.Burgisser. Three-Dimensional Structure of 6-Pyruvoyl Tetrahydropterin Synthase, An Enzyme Involved in Tetrahydrobiopterin Biosynthesis. Embo J. V. 13 1255 1994.
ISSN: ISSN 0261-4189
PubMed: 8137809