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Zinc in PDB 1gtq: 6-Pyruvoyl Tetrahydropterin Synthase

Enzymatic activity of 6-Pyruvoyl Tetrahydropterin Synthase

All present enzymatic activity of 6-Pyruvoyl Tetrahydropterin Synthase:
4.6.1.10;

Protein crystallography data

The structure of 6-Pyruvoyl Tetrahydropterin Synthase, PDB code: 1gtq was solved by H.Nar, R.Huber, C.W.Heizmann, B.Thoeny, D.Buergisser, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 8.00 / 2.30
Space group P 3 2 1
Cell size a, b, c (Å), α, β, γ (°) 122.300, 122.300, 61.600, 90.00, 90.00, 120.00
R / Rfree (%) 20.4 / n/a

Zinc Binding Sites:

The binding sites of Zinc atom in the 6-Pyruvoyl Tetrahydropterin Synthase (pdb code 1gtq). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the 6-Pyruvoyl Tetrahydropterin Synthase, PDB code: 1gtq:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 1gtq

Go back to Zinc Binding Sites List in 1gtq
Zinc binding site 1 out of 2 in the 6-Pyruvoyl Tetrahydropterin Synthase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of 6-Pyruvoyl Tetrahydropterin Synthase within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn200

b:12.0
occ:1.00
NE2 A:HIS50 2.2 3.4 1.0
NE2 A:HIS48 2.2 18.0 1.0
NE2 A:HIS23 2.3 8.5 1.0
CE1 A:HIS23 2.9 5.4 1.0
CD2 A:HIS48 3.2 17.2 1.0
CE1 A:HIS50 3.2 2.6 1.0
CD2 A:HIS50 3.2 3.0 1.0
CE1 A:HIS48 3.3 16.9 1.0
OE2 A:GLU133 3.5 24.4 1.0
CD2 A:HIS23 3.5 8.7 1.0
CD A:GLU133 3.8 21.4 1.0
ND1 A:HIS23 4.2 5.2 1.0
OE1 A:GLU133 4.2 26.5 1.0
ND1 A:HIS50 4.3 4.8 1.0
CG A:HIS48 4.4 15.3 1.0
CG A:HIS50 4.4 2.2 1.0
ND1 A:HIS48 4.4 15.2 1.0
SG A:CYS42 4.5 12.3 1.0
CG A:HIS23 4.5 4.2 1.0
CG A:GLU133 4.5 14.1 1.0
H2 A:HOH505 4.8 20.0 1.0
HH A:TYR52 4.8 20.0 1.0
CB A:CYS42 4.9 12.2 1.0
HD1 A:HIS23 5.0 20.0 1.0

Zinc binding site 2 out of 2 in 1gtq

Go back to Zinc Binding Sites List in 1gtq
Zinc binding site 2 out of 2 in the 6-Pyruvoyl Tetrahydropterin Synthase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of 6-Pyruvoyl Tetrahydropterin Synthase within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn200

b:12.0
occ:1.00
NE2 B:HIS50 2.1 6.1 1.0
NE2 B:HIS48 2.2 11.0 1.0
NE2 B:HIS23 2.3 13.5 1.0
CE1 B:HIS50 3.0 4.9 1.0
CD2 B:HIS50 3.2 4.5 1.0
OE2 B:GLU133 3.2 29.4 1.0
CE1 B:HIS48 3.2 13.5 1.0
CE1 B:HIS23 3.2 13.0 1.0
CD2 B:HIS48 3.3 11.6 1.0
CD2 B:HIS23 3.4 12.5 1.0
CD B:GLU133 3.7 27.6 1.0
OE1 B:GLU133 4.0 33.7 1.0
ND1 B:HIS50 4.2 2.0 1.0
CG B:HIS50 4.3 2.3 1.0
ND1 B:HIS48 4.4 14.7 1.0
ND1 B:HIS23 4.4 12.4 1.0
SG B:CYS42 4.4 22.4 1.0
CG B:HIS48 4.4 12.2 1.0
H1 B:HOH528 4.5 20.0 1.0
CG B:HIS23 4.6 8.7 1.0
HH B:TYR52 4.6 20.0 1.0
CG B:GLU133 4.6 22.8 1.0
CB B:CYS42 4.8 21.9 1.0
OH B:TYR52 5.0 2.7 1.0

Reference:

H.Nar, R.Huber, C.W.Heizmann, B.Thony, D.Burgisser. Three-Dimensional Structure of 6-Pyruvoyl Tetrahydropterin Synthase, An Enzyme Involved in Tetrahydrobiopterin Biosynthesis. Embo J. V. 13 1255 1994.
ISSN: ISSN 0261-4189
PubMed: 8137809
Page generated: Wed Dec 16 02:50:29 2020

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